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    UNIFORM EPI-ILLUMINATION OF PLANAR SAMPLES
    2.
    发明申请
    UNIFORM EPI-ILLUMINATION OF PLANAR SAMPLES 审中-公开
    平面图的均匀平面图

    公开(公告)号：WO2013130183A1

    公开(公告)日：2013-09-06

    申请号：PCT/US2013/021378

    申请日：2013-01-14

    Applicant: BIO-RAD LABORATORIES, INC.

    Inventor： HILLENDAHL, James W. ,  PEREZ, Evelio

    IPC: H01L27/00

    CPC classification number: F21V21/005 ,  F21V9/083 ,  F21V13/02 ,  G01N21/255 ,  G01N21/6452 ,  G01N21/6456 ,  G01N27/447 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/06 ,  G01N2201/0626 ,  G01N2201/0635

    Abstract: A planar sample, particularly of the type used in biological laboratories for detection and sometimes analysis of two-dimensional arrays of proteins, nucleic acids, or other biological species, is illuminated by epi-illumination using optically filtered line lights that are arranged along opposing parallel sides of a rectangle in which the sample array resides, with two coaxial line lights on each side of the rectangle, and the two on any given side being separated by a gap whose optimal width depends on the wavelength band transmitted by the optical filter. Surprisingly, the gap eliminates the peak in intensity at the center of the sample area and the decrease that occurs from the center outward that would otherwise occur with a single continuous filtered line light, producing instead a substantially uniform intensity along the direction parallel to the line lights.

    Abstract translation: 平面样品，特别是用于生物实验室中用于检测和有时分析蛋白质，核酸或其他生物物种的二维阵列的类型的样品，通过使用沿着相对的平行排列的光学滤波的线光照射外照射 其中样品阵列所在的矩形的边，在矩形的每一侧具有两根同轴线灯，并且任一给定侧上的两个被一个间隙隔开，该间隙的最佳宽度取决于由滤光器传输的波长带。 令人惊奇的是，间隙消除了样品区域中心处的强度峰值以及从中心向外发生的减少，否则这将以单个连续过滤的线路光发生，从而产生沿着平行于线的方向的基本均匀的强度 灯。

    BIOCHEMICAL ASSAY DETECTION USING A FIBER OPTIC EXCITER
    3.
    发明申请
    BIOCHEMICAL ASSAY DETECTION USING A FIBER OPTIC EXCITER 审中-公开
    生物化学测定使用光纤光栅EXCITER

    公开(公告)号：WO2008033625A2

    公开(公告)日：2008-03-20

    申请号：PCT/US2007/075329

    申请日：2007-08-07

    Applicant: BIO-RAD LABORATORIES, INC. ,  HILLENDAHL, James W. ,  WALDBESER, David E.

    Inventor： HILLENDAHL, James W. ,  WALDBESER, David E.

    IPC: G02B6/32

    CPC classification number: G01N21/6452 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484

    Abstract: Biochemical assays of samples in receptacles, in gels, in blots, in arrays and the like, and that utilize excitation and light emission as labels for detection are enhanced by an illumination and detection system that supplies excitation light through an optical fiber that transmits excitation light from an excitation light source to the sample. Emission light produced by the excitation is then collected by a lens and converted to a signal that is compiled by conventional software for analysis. The optical fiber transfixes (passes through) the lens via a slot or other opening and is preferably offset from the center of the lens. The optical fiber and collecting lens can either be on the same side of the sample or on opposite sides, i.e., one above and the other below. The optical fiber and the light collecting lens are arranged such that the direction of travel of the excitation light and the direction along which the emission light is collected are not coaxial, and preferably both are at an acute angle to the axis normal to the mouth of the receptacle. Illumination systems are also disclosed in which a ultraviolet, visible, or near-infrared light source is optically coupled to an optical fiber.

    Abstract translation: 通过照射和检测系统增强了在容器，凝胶，印迹，阵列等中的样品和利用激发和发光作为检测标签的样品的生物化学分析，其通过透射激发光的光纤提供激发光 从激发光源到样品。 由激发产生的发射光然后由透镜收集并转换成由常规软件编译的信号用于分析。 光纤经由狭槽或其他开口将透镜经过（透过）透镜，并且优选地偏离透镜的中心。 光纤和收集透镜可以在样品的相同侧或者在相对的两侧，即一个在另一个之上。 光纤和聚光透镜被布置成使得激发光的行进方向和发射光被收集的方向不同轴，并且优选地两者都与垂直于嘴的轴成锐角 容器 还公开了照明系统，其中紫外线，可见光或近红外光源光学耦合到光纤。

    UNIFORM EPI-ILLUMINATION OF PLANAR SAMPLES
    5.
    发明公开
    UNIFORM EPI-ILLUMINATION OF PLANAR SAMPLES 有权
    平面样本的均匀EPI照射

    公开(公告)号：EP2820676A1

    公开(公告)日：2015-01-07

    申请号：EP13755695.7

    申请日：2013-01-14

    Applicant: Bio-rad Laboratories, Inc.

    Inventor： HILLENDAHL, James W. ,  PEREZ, Evelio

    IPC: H01L27/00

    CPC classification number: F21V21/005 ,  F21V9/083 ,  F21V13/02 ,  G01N21/255 ,  G01N21/6452 ,  G01N21/6456 ,  G01N27/447 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/06 ,  G01N2201/0626 ,  G01N2201/0635

    Abstract: A planar sample, particularly of the type used in biological laboratories for detection and sometimes analysis of two-dimensional arrays of proteins, nucleic acids, or other biological species, is illuminated by epi-illumination using optically filtered line lights that are arranged along opposing parallel sides of a rectangle in which the sample array resides, with two coaxial line lights on each side of the rectangle, and the two on any given side being separated by a gap whose optimal width depends on the wavelength band transmitted by the optical filter. Surprisingly, the gap eliminates the peak in intensity at the center of the sample area and the decrease that occurs from the center outward that would otherwise occur with a single continuous filtered line light, producing instead a substantially uniform intensity along the direction parallel to the line lights.

    Abstract translation: 平面样品，特别是用于生物实验室中用于检测蛋白质，核酸或其他生物物种的二维阵列以及有时分析蛋白质，核酸或其他生物物种的二维阵列的类型的平面样品，使用光学滤波的线光照射，所述光学滤波的线光沿着相对平行 样本阵列所在的矩形的两侧，在矩形的每一侧上具有两个同轴线光源，并且在任何给定侧上的两个由间隙隔开，该间隙的最佳宽度取决于由光学滤波器传输的波长带。 令人惊讶的是，该间隙消除了样品区域中心处的强度峰值以及从中心向外发生的减少，否则将发生在单个连续的过滤后的线光下，而是沿平行于线的方向产生基本上均匀的强度 灯。

    BIOCHEMICAL ASSAY DETECTION USING A FIBER OPTIC EXCITER
    6.
    发明公开
    BIOCHEMICAL ASSAY DETECTION USING A FIBER OPTIC EXCITER 审中-公开
    生化探测方法的光纤代理的方式

    公开(公告)号：EP2062079A2

    公开(公告)日：2009-05-27

    申请号：EP07813831.0

    申请日：2007-08-07

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： HILLENDAHL, James W. ,  WALDBESER, David E.

    IPC: G02B6/32

    CPC classification number: G01N21/6452 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484

    Abstract: Biochemical assays that utilize excitation and light emission as labels for detection are enhanced by an illumination and detection system that supplies excitation light through an optical fiber that transmits excitation light from an excitation light source to the sample Emission light produced by the excitation is then collected by a lens and converted to a signal that is compiled by conventional softwar for analysis The optical fiber transfixes (passes through) the lens via a slot or other opening and is preferably offset from the center of the lens The optical fiber and the light collecting lens are arranged such that the direction of travel of the excitation light and the direction along which the emission light is collected are not coaxial, and preferably both are at an acute angle to the axis normal to the mouth of the receptacle.

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