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    BEAD READER
    1.
    发明申请
    BEAD READER 审中-公开
    珠读卡器

    公开(公告)号：WO2011064778A2

    公开(公告)日：2011-06-03

    申请号：PCT/IL2010/000993

    申请日：2010-11-29

    Applicant: BIO-RAD LABORATORIES INC. ,  RAN, Boaz ,  SLUSZNY, Chanan ,  NIMRI, Shay

    Inventor： RAN, Boaz ,  SLUSZNY, Chanan ,  NIMRI, Shay

    IPC: G01N21/64

    CPC classification number: G01N21/76 ,  G01N15/0612 ,  G01N15/1463 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/78 ,  G01N35/0098 ,  G01N2015/1486 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2035/1046 ,  Y10T436/25

    Abstract: A method of determining a normalized quantity of an analyte adhering to beads in a detection area of a bead-based assaying system, the method comprising: a) causing a complex of the analyte to fluorescently or chemically emit a first light, or to release a dye; b) measuring an integrated intensity of the first light emitted from the beads in the detection area, or a concentration of the dye released from the beads in the detection area, or both; c) causing light to interact with the beads in the detection area, the interaction not depending on whether or how much analyte is adhering to the beads; d) measuring a second light resulting from the interaction with the beads which does not depend on the analyte; and e) determining the normalized quantity of analyte from the integrated intensity of the first light or concentration of the dye or both, and from the measured second light.

    Abstract translation: 一种确定在珠基测定系统的检测区域中附着于珠的分析物的标准化量的方法，所述方法包括：a）使分析物的复合物荧光或化学发射第一光，或释放 染料; b）测量从检测区域中的珠子发射的第一光的集成强度或从检测区域中的珠粒释放的染料的浓度，或两者; c）使光与检测区域中的珠粒相互作用，所述相互作用不取决于分析物是否或多少附着到珠粒上; d）测量与不依赖于分析物的珠的相互作用产生的第二光; 以及e）根据所述第一光的积分强度或所述染料或两者的浓度以及所测量的第二光来确定分析物的归一化量。

    OPTICAL DETECTION SYSTEM FOR LIQUID SAMPLES
    2.
    发明申请
    OPTICAL DETECTION SYSTEM FOR LIQUID SAMPLES 审中-公开
    液体样品光学检测系统

    公开(公告)号：WO2013186672A2

    公开(公告)日：2013-12-19

    申请号：PCT/IB2013/054660

    申请日：2013-06-06

    Applicant: BIO-RAD LABORATORIES INC.

    Inventor： URI, Yochanan ,  RAN, Boaz ,  NOTCOVICH, Ariel G. ,  NIMRI, Shay

    IPC: G01N21/03 ,  G01N21/55

    CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

    Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

    Abstract translation: 一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于 相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。

    SURFACE PLASMON RESONANCE SENSOR
    4.
    发明授权
    SURFACE PLASMON RESONANCE SENSOR 有权
    表面等离子体共振传感器

    公开(公告)号：EP1581800B1

    公开(公告)日：2009-06-17

    申请号：EP02808314.5

    申请日：2002-12-25

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： RAN, Boaz ,  NOTCOVICH, Ariel, G. ,  LIPSON, Ariel ,  NIMRI, Shay ,  LIPSON, Stephen, G. ,  LIPSON, Doron

    IPC: G01N21/55 ,  G01J3/30

    CPC classification number: G01N21/55 ,  G01N21/553 ,  G01N2021/058

    Abstract: An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.

    BEAD READER
    6.
    发明公开
    BEAD READER 有权
    光学检测单元与珠测试系统

    公开(公告)号：EP2507620A2

    公开(公告)日：2012-10-10

    申请号：EP10795779.7

    申请日：2010-11-29

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： RAN, Boaz ,  SLUSZNY, Chanan ,  NIMRI, Shay

    IPC: G01N21/64

    CPC classification number: G01N21/76 ,  G01N15/0612 ,  G01N15/1463 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/78 ,  G01N35/0098 ,  G01N2015/1486 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2035/1046 ,  Y10T436/25

    Abstract: A method of determining a normalized quantity of an analyte adhering to beads ( 310 ) in a detection area ( 312 ) of a bead-based assaying system ( 300 ), the method comprising: a) causing a complex of the analyte to fluorescently or chemically emit a first light ( 2 ), or to release a dye; b) measuring an integrated intensity of the first light emitted from the beads in the detection area, or a concentration of the dye released from the beads in the detection area, or both; c) causing light ( 1 ) to interact with the beads in the detection area, the interaction not depending on whether or how much analyte is adhering to the beads; d) measuring a second light ( 1 ) resulting from the interaction with the beads which does not depend on the analyte; and e) determining the normalized quantity of analyte from the integrated intensity of the first light or concentration of the dye or both, and from the measured second light.

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