公开(公告)号：WO2010122547A1

公开(公告)日：2010-10-28

申请号：PCT/IL2010/000306

申请日：2010-04-18

Applicant: BIO-RAD LABORATORIES INC. ,  RAN, Boaz ,  BARAK, Itay

Inventor： RAN, Boaz ,  BARAK, Itay

IPC: G01N21/55 ,  G02B3/00

CPC classification number: G01N21/553 ,  G02B3/005 ,  G02B5/008

Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.

Abstract translation: 一种用于在全内反射下测量ev逝波现象的系统，所述系统包括：a）感测表面，包括多个感兴趣的区域; b）照明子系统，包括光源，其在入射角范围上照射感测表面上的每个感兴趣区域; c）检测器，其响应于其在不同位置处接收的光的强度不同; 以及d）包括主要光学元件和多个次要元件的投影光学元件，所述主要光学器件将所述照射的感测表面的图像投影到所述次级元件上，所述次级元件将其接收的光投射到所述检测器上，使得可以确定， 根据检测器的响应，从感兴趣区域反射多少光，作为该区域的角度范围内的入射角的函数。

公开(公告)号：WO2008142689A1

公开(公告)日：2008-11-27

申请号：PCT/IL2008/000692

申请日：2008-05-21

Applicant: BIO-RAD LABORATORIES INC. ,  RAN, Boaz ,  ROSENZWEIG, Tal ,  NOTCOVICH, Ariel G. ,  SHEMESH, Ariel ,  URI, Yochanan ,  KANEVSKY, Michael ,  HILLENDAHL, James W. ,  LIRAZ, Barak Abraham

Inventor： RAN, Boaz ,  ROSENZWEIG, Tal ,  NOTCOVICH, Ariel G. ,  SHEMESH, Ariel ,  URI, Yochanan ,  KANEVSKY, Michael ,  HILLENDAHL, James W. ,  LIRAZ, Barak Abraham

IPC: G01N21/55

CPC classification number: G01N21/553

Abstract: An SPR or other optical resonance based analysis system in which, light is provided at multiple angles to a specimen and then the light modified by the specimen is processed to select only some of the light. Optionally, the processing selects light at a particular incidence angle. Optionally, the detection is by imaging of the light on a 2D imager array.

Abstract translation: 基于SPR或其他基于光学共振的分析系统，其中以样品的多个角度提供光，然后处理由样本改变的光以仅选择一些光。 可选地，该处理以特定入射角选择光。 可选地，通过在2D成像器阵列上对光进行成像来进行检测。

公开(公告)号：WO2021252668A1

公开(公告)日：2021-12-16

申请号：PCT/US2021/036667

申请日：2021-06-09

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： NIMRI, Shai ,  URI, Yochanan ,  RAN, Boaz

IPC: G01N33/543 ,  G01N33/564 ,  G01N33/68 ,  B01L2300/0654 ,  B01L3/502715 ,  B01L3/5085 ,  G01N2035/0477 ,  G01N2035/103 ,  G01N2035/1062 ,  G01N21/00 ,  G01N33/5302 ,  G01N33/54326 ,  G01N35/0098 ,  G01N35/04 ,  G01N35/10

Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.

公开(公告)号：WO2011064778A2

公开(公告)日：2011-06-03

申请号：PCT/IL2010/000993

申请日：2010-11-29

Applicant: BIO-RAD LABORATORIES INC. ,  RAN, Boaz ,  SLUSZNY, Chanan ,  NIMRI, Shay

Inventor： RAN, Boaz ,  SLUSZNY, Chanan ,  NIMRI, Shay

IPC: G01N21/64

CPC classification number: G01N21/76 ,  G01N15/0612 ,  G01N15/1463 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/78 ,  G01N35/0098 ,  G01N2015/1486 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2035/1046 ,  Y10T436/25

Abstract: A method of determining a normalized quantity of an analyte adhering to beads in a detection area of a bead-based assaying system, the method comprising: a) causing a complex of the analyte to fluorescently or chemically emit a first light, or to release a dye; b) measuring an integrated intensity of the first light emitted from the beads in the detection area, or a concentration of the dye released from the beads in the detection area, or both; c) causing light to interact with the beads in the detection area, the interaction not depending on whether or how much analyte is adhering to the beads; d) measuring a second light resulting from the interaction with the beads which does not depend on the analyte; and e) determining the normalized quantity of analyte from the integrated intensity of the first light or concentration of the dye or both, and from the measured second light.

Abstract translation: 一种确定在珠基测定系统的检测区域中附着于珠的分析物的标准化量的方法，所述方法包括：a）使分析物的复合物荧光或化学发射第一光，或释放 染料; b）测量从检测区域中的珠子发射的第一光的集成强度或从检测区域中的珠粒释放的染料的浓度，或两者; c）使光与检测区域中的珠粒相互作用，所述相互作用不取决于分析物是否或多少附着到珠粒上; d）测量与不依赖于分析物的珠的相互作用产生的第二光; 以及e）根据所述第一光的积分强度或所述染料或两者的浓度以及所测量的第二光来确定分析物的归一化量。

公开(公告)号：WO2017015164A1

公开(公告)日：2017-01-26

申请号：PCT/US2016/042658

申请日：2016-07-15

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： SWIHART, Steve ,  THRUSH, Evan ,  URI, Yoachanan ,  RAN, Boaz ,  BARAK, Itay ,  MCDONALD, Kevin

IPC: G01N21/00 ,  G01N21/17 ,  G01N21/33 ,  G01N21/35 ,  G01N21/64

CPC classification number: G02B6/08 ,  G01N21/6454 ,  G01N27/44721 ,  G01N2021/6484 ,  G02B5/22 ,  G02B5/28

Abstract: Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.

Abstract translation: 提供了用于接触成像的设备，系统，方法和套件。 接触成像装置包括成像传感器，机械耦合到成像传感器的固定光纤面板以及机械耦合到固定光纤面板的光学滤光层。 光学滤光层可以包括干涉滤光器，吸收滤光器和/或可移除的光纤面板。 接触成像装置可用于通过基于波长和/或入射角滤除激发光来对荧光样品进行成像。

公开(公告)号：WO2016007353A1

公开(公告)日：2016-01-14

申请号：PCT/US2015/038856

申请日：2015-07-01

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： URI, Yochanan ,  RAN, Boaz ,  BARAK, Itay ,  SWIHART, Steven ,  THRUSH, Evan

IPC: G01N21/62 ,  G01N33/483 ,  G01N1/04

CPC classification number: H04N5/2252 ,  G01N21/76 ,  G01N21/763 ,  G01N2201/0221

Abstract: Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays. In one embodiment, an imaging cassette comprising a base support, an image sensor, and a light-tight lid, wherein the imaging cassette is configured to receive a piece of film.

Abstract translation: 本文提供了用于检测发光和/或放射性信号的成像盒。 这样的盒可用于常见的生物测定，例如免疫测定，核苷酸检测测定和其他亲和测定。 在一个实施例中，一种包括基座支架，图像传感器和不透光盖子的成像盒，其中所述成像盒被配置成接收一片胶片。

公开(公告)号：WO2015089081A1

公开(公告)日：2015-06-18

申请号：PCT/US2014/069359

申请日：2014-12-09

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： RAN, Boaz ,  SWIHART, Steve ,  THRUSH, Evan ,  BARAK, Itay

IPC: H01L23/552

CPC classification number: H04N5/361 ,  H01L2924/0002 ,  H04N5/365 ,  H01L2924/00

Abstract: One embodiment of the invention is directed to an imaging device comprising an image sensor comprising an array of pixels, and a mask coupled with the image sensor, the mask configured to darken at least one pixel in the array of pixels.

Abstract translation: 本发明的一个实施例涉及一种包括包括像素阵列的图像传感器和与图像传感器耦合的掩模的成像装置，该掩模被配置为使像素阵列中的至少一个像素变暗。

公开(公告)号：WO2016141052A1

公开(公告)日：2016-09-09

申请号：PCT/US2016/020441

申请日：2016-03-02

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： RAN, Boaz

IPC: C07K1/26 ,  G01N27/447

CPC classification number: G01N27/44747 ,  G01N27/44739

Abstract: Integrated electrophoresis and electroblotting systems and methods are provided. In one embodiment, a cassette includes a separation gel and a sheet adjacent to a surface of the separation gel, wherein the sheet is configured to be removed from the cassette without opening the cassette. Systems and methods are also described and illustrated.

Abstract translation: 提供了集成的电泳和电泳印制系统和方法。 在一个实施例中，盒包括分离凝胶和与分离凝胶的表面相邻的片，其中片被配置为在不打开盒的情况下从盒中取出。 还描述和说明了系统和方法。

公开(公告)号：WO2015089031A1

公开(公告)日：2015-06-18

申请号：PCT/US2014/069281

申请日：2014-12-09

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： SWIHART, Steve ,  THRUSH, Evan ,  RAN, Boaz

IPC: G01N21/27

CPC classification number: H04N5/2355 ,  G01N21/272 ,  G01N21/6408 ,  G01N21/6456 ,  G01N21/76 ,  H04N5/2173 ,  H04N5/2353 ,  H04N5/35545 ,  H04N5/361 ,  H04N5/365

Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.

Abstract translation: 本文公开的方法和数字成像装置适于在一段时间内使用来自样品的一系列短的曝光来捕获化学反应中的样本的图像。 使用数字成像设备中的图像传感器的像素阵列来捕获一系列短曝光，其被配置为执行连续的非破坏性读取操作，以从像素阵列读出样本的一组非破坏性读取图像 。 在一个实施例中，通过延迟读出直到化学反应结束或接近化学反应结束来捕获图像，以减少图像中的读取噪声。 可以连续地监视从图像传感器读出的信号，并且可以自动地或基于来自用户的命令中断图像的捕获。 然后可以在图形显示中显示捕获的图像。

公开(公告)号：WO2013186672A2

公开(公告)日：2013-12-19

申请号：PCT/IB2013/054660

申请日：2013-06-06

Applicant: BIO-RAD LABORATORIES INC.

Inventor： URI, Yochanan ,  RAN, Boaz ,  NOTCOVICH, Ariel G. ,  NIMRI, Shay

IPC: G01N21/03 ,  G01N21/55

CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

Abstract translation: 一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于 相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。