公开(公告)号：WO2008142689A1

公开(公告)日：2008-11-27

申请号：PCT/IL2008/000692

申请日：2008-05-21

Applicant: BIO-RAD LABORATORIES INC. ,  RAN, Boaz ,  ROSENZWEIG, Tal ,  NOTCOVICH, Ariel G. ,  SHEMESH, Ariel ,  URI, Yochanan ,  KANEVSKY, Michael ,  HILLENDAHL, James W. ,  LIRAZ, Barak Abraham

Inventor： RAN, Boaz ,  ROSENZWEIG, Tal ,  NOTCOVICH, Ariel G. ,  SHEMESH, Ariel ,  URI, Yochanan ,  KANEVSKY, Michael ,  HILLENDAHL, James W. ,  LIRAZ, Barak Abraham

IPC: G01N21/55

CPC classification number: G01N21/553

Abstract: An SPR or other optical resonance based analysis system in which, light is provided at multiple angles to a specimen and then the light modified by the specimen is processed to select only some of the light. Optionally, the processing selects light at a particular incidence angle. Optionally, the detection is by imaging of the light on a 2D imager array.

Abstract translation: 基于SPR或其他基于光学共振的分析系统，其中以样品的多个角度提供光，然后处理由样本改变的光以仅选择一些光。 可选地，该处理以特定入射角选择光。 可选地，通过在2D成像器阵列上对光进行成像来进行检测。

公开(公告)号：WO2021252668A1

公开(公告)日：2021-12-16

申请号：PCT/US2021/036667

申请日：2021-06-09

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： NIMRI, Shai ,  URI, Yochanan ,  RAN, Boaz

IPC: G01N33/543 ,  G01N33/564 ,  G01N33/68 ,  B01L2300/0654 ,  B01L3/502715 ,  B01L3/5085 ,  G01N2035/0477 ,  G01N2035/103 ,  G01N2035/1062 ,  G01N21/00 ,  G01N33/5302 ,  G01N33/54326 ,  G01N35/0098 ,  G01N35/04 ,  G01N35/10

Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.

公开(公告)号：WO2019005565A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/038603

申请日：2018-06-20

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： URI, Yochanan ,  KOCHETKOV, Igor ,  ISSMAN, Uri ,  AHARON, Shai

IPC: G01N27/447 ,  G01N1/28 ,  B65H3/08

Abstract: Gel cassette opening devices and methods for opening gel cassettes are provided.

公开(公告)号：WO2019150189A1

公开(公告)日：2019-08-08

申请号：PCT/IB2019/000007

申请日：2019-02-05

Applicant: URI, Yochanan ,  BARAK, Itay ,  LOVCHIK, Robert ,  TAYLOR, David, P. ,  BUERGE, Marcel ,  KAIGALA, Govind, V. ,  BIO-RAD EUROPE GMBH ,  BIO-RAD LABORATORIES, INC.

Inventor： URI, Yochanan ,  BARAK, Itay ,  LOVCHIK, Robert ,  TAYLOR, David, P. ,  BUERGE, Marcel ,  KAIGALA, Govind, V.

IPC: B01L3/00 ,  B01L99/00 ,  B01L3/02

CPC classification number: B01L3/502707 ,  B01L3/0293 ,  B01L3/502761 ,  B01L99/00 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2200/0647 ,  B01L2200/141 ,  B01L2300/0832

Abstract: The present disclosure is notably directed to a microfluidic probe head (202), or MFP head, comprising a processing surface (204) having liquid injection and liquid aspiration apertures, as well as projections (205) extending from the processing surface (204). The arrangement of injection and aspiration apertures provides for a hydrodynamic flow confinement within a processing region that is formed between the processing surface (204) and a substrate (104) or sample surface (for example, the bottom of a microtiter plate sample well (102)), typically located beneath the processing surface (204). The disclosure is further directed to related microfluidic probe devices, and methods of operation of such an MFP head, notably to deposit cells on a surface.

公开(公告)号：WO2016100216A1

公开(公告)日：2016-06-23

申请号：PCT/US2015/065571

申请日：2015-12-14

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： URI, Yochanan ,  ISSMAN, Uri ,  KOCHETKOV, Igor ,  BARAK, Itay ,  AHARON, Shai ,  NIMRI, Shai

IPC: G01N27/447

CPC classification number: G01N27/44756 ,  G01N27/44721 ,  G01N27/44726 ,  G01N27/44739 ,  G01N27/44743 ,  G01N27/44782 ,  G01N33/54366

Abstract: Horizontal gel electrophoresis devices and methods of extracting a gel from a gel housing are provided. The devices allow for extraction of gels without having to open the housing comprising the gel. The devices include gel cassettes that simplify the automation of gel electrophoresis and electroblotting of proteins. Also provided are devices that allow for horizontal gel electrophoresis without the need to from a liquid seal between the buffer reservoir and the gel housing. Also described are methods for extracting a gel from a housing without opening the housing.

Abstract translation: 提供了水凝胶电泳装置和从凝胶壳体提取凝胶的方法。 该装置允许提取凝胶，而不必打开包含凝胶的壳体。 该装置包括凝胶盒，其简化了凝胶电泳的自动化和蛋白质的电印迹。 还提供了允许水平凝胶电泳而不需要在缓冲储存器和凝胶壳体之间的液体密封的装置。 还描述了在不打开壳体的情况下从壳体中提取凝胶的方法。

公开(公告)号：WO2016007353A1

公开(公告)日：2016-01-14

申请号：PCT/US2015/038856

申请日：2015-07-01

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： URI, Yochanan ,  RAN, Boaz ,  BARAK, Itay ,  SWIHART, Steven ,  THRUSH, Evan

IPC: G01N21/62 ,  G01N33/483 ,  G01N1/04

CPC classification number: H04N5/2252 ,  G01N21/76 ,  G01N21/763 ,  G01N2201/0221

Abstract: Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays. In one embodiment, an imaging cassette comprising a base support, an image sensor, and a light-tight lid, wherein the imaging cassette is configured to receive a piece of film.

Abstract translation: 本文提供了用于检测发光和/或放射性信号的成像盒。 这样的盒可用于常见的生物测定，例如免疫测定，核苷酸检测测定和其他亲和测定。 在一个实施例中，一种包括基座支架，图像传感器和不透光盖子的成像盒，其中所述成像盒被配置成接收一片胶片。

公开(公告)号：WO2019150189A8

公开(公告)日：2019-08-08

申请号：PCT/IB2019/000007

申请日：2019-02-05

Applicant: LOVCHIK, Robert ,  TAYLOR, David, P. ,  BUERGE, Marcel ,  KAIGALA, Govind, V. ,  BIO-RAD EUROPE GMBH ,  BIO-RAD LABORATORIES, INC.

Inventor： LOVCHIK, Robert ,  TAYLOR, David, P. ,  BUERGE, Marcel ,  KAIGALA, Govind, V. ,  URI, Yochanan ,  BARAK, Itay

IPC: B01L3/00 ,  B01L99/00 ,  B01L3/02

Abstract: The present disclosure is notably directed to a microfluidic probe head (202), or MFP head, comprising a processing surface (204) having liquid injection and liquid aspiration apertures, as well as projections (205) extending from the processing surface (204). The arrangement of injection and aspiration apertures provides for a hydrodynamic flow confinement within a processing region that is formed between the processing surface (204) and a substrate (104) or sample surface (for example, the bottom of a microtiter plate sample well (102)), typically located beneath the processing surface (204). The disclosure is further directed to related microfluidic probe devices, and methods of operation of such an MFP head, notably to deposit cells on a surface.

公开(公告)号：WO2018191052A1

公开(公告)日：2018-10-18

申请号：PCT/US2018/025706

申请日：2018-04-02

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： URI, Yochanan ,  KOCHETKOV, Igor ,  AHARON, Shai ,  BARAK, Itay ,  ISSMAN, Uri

IPC: G01N1/18 ,  B67D7/02 ,  G01F11/28 ,  B65B3/30 ,  B01D15/24 ,  F04F1/06 ,  B01J4/02

Abstract: Fraction collector dispensers and methods of using such dispensers are provided. In one embodiment, the dispenser includes an inlet for receiving liquid from a liquid source, wherein the inlet is in fluid communication with an outlet from which liquid is dispensed into a receptacle; and a reservoir in fluid communication with a flow path between the inlet and outlet, wherein the reservoir comprises trapped air therein and is configured to receive liquid during movement of the dispenser between receptacles or during movement of receptacles between dispense positions, wherein the dispenser is moveable between a first receptacle and a second receptacle or the receptacles are moveable between dispense positions.

公开(公告)号：WO2013186672A2

公开(公告)日：2013-12-19

申请号：PCT/IB2013/054660

申请日：2013-06-06

Applicant: BIO-RAD LABORATORIES INC.

Inventor： URI, Yochanan ,  RAN, Boaz ,  NOTCOVICH, Ariel G. ,  NIMRI, Shay

IPC: G01N21/03 ,  G01N21/55

CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

Abstract translation: 一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于 相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。

公开(公告)号：EP3234578A1

公开(公告)日：2017-10-25

申请号：EP15870806.5

申请日：2015-12-14

Applicant: Bio-Rad Laboratories, Inc.

Inventor： URI, Yochanan ,  ISSMAN, Uri ,  KOCHETKOV, Igor ,  BARAK, Itay ,  AHARON, Shai ,  NIMRI, Shai

IPC: G01N27/447

CPC classification number: G01N27/44756 ,  G01N27/44721 ,  G01N27/44726 ,  G01N27/44739 ,  G01N27/44743 ,  G01N27/44782 ,  G01N33/54366

Abstract: Horizontal gel electrophoresis devices and methods of extracting a gel from a gel housing are provided. The devices allow for extraction of gels without having to open the housing comprising the gel. The devices include gel cassettes that simplify the automation of gel electrophoresis and electroblotting of proteins. Also provided are devices that allow for horizontal gel electrophoresis without the need to from a liquid seal between the buffer reservoir and the gel housing. Also described are methods for extracting a gel from a housing without opening the housing.

Abstract translation: 提供了水平凝胶电泳装置和从凝胶壳体中提取凝胶的方法。 该设备允许提取凝胶而不必打开包含凝胶的外壳。 该设备包括凝胶盒，可简化凝胶电泳和蛋白质电印迹的自动化。 还提供了允许进行水平凝胶电泳而不需要在缓冲液储存器和凝胶壳体之间进行液体密封的装置。 还描述了用于在不打开壳体的情况下从壳体中提取凝胶的方法。