公开(公告)号：AU2015283850B2

公开(公告)日：2020-06-04

申请号：AU2015283850

申请日：2015-07-02

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： DI FRANCESCO MARIA EMILIA ,  JONES PHILIP ,  HEFFERNAN TIMOTHY ,  HAMILTON MATTHEW ,  KANG ZHIJUN ,  SOTH MICHAEL P ,  BURKE JASON P ,  LE KANG ,  CARROLL CHRISTOPHER LAWRENCE ,  PALMER WYLIE ,  LEWIS RICHARD ,  MCAFOOS TIMOTHY ,  CZAKO BARBARA ,  LIU GANG ,  THEROFF JAY ,  HERRERA ZACHARY ,  YAU ANNE

IPC: C07D401/06 ,  A61K31/4439 ,  C07D417/14

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS I mediated diseases, such as cancer, having the structure of Formula I. Methods of inhibition GLS I activity in a human or animal subject are also provided. Accordingly, the inventors herein disclose new compositions and methods for inhibiting glutaminase activity. The present disclosure relates to new heterocyclic compounds and compositions, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of GLS 1 activity in a human or animal subject are also provided for the treatment of diseases such as cancer.

公开(公告)号：BR112016030730A2

公开(公告)日：2017-08-22

申请号：BR112016030730

申请日：2015-07-02

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： CZAKO BARBARA ,  LIU GANG ,  THEROFF JAY ,  HERRERA ZACHARY ,  YAU ANNE ,  DI FRANCESCO MARIA EMILIA ,  JONES PHILIP ,  HEFFERNAN TIMOTHY ,  HAMILTON MATTHEW ,  KANG ZHIJUN ,  SOTH MICHAEL P ,  BURKE JASON P ,  LE KANG ,  CARROLL CHRISTOPHER LAWRENCE ,  PALMER WYLIE ,  LEWIS RICHARD ,  MCAFOOS TIMOTHY

公开(公告)号：AU2015283850A1

公开(公告)日：2016-12-15

申请号：AU2015283850

申请日：2015-07-02

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： CZAKO BARBARA ,  LIU GANG ,  THEROFF JAY ,  HERRERA ZACHARY ,  YAU ANNE ,  DI FRANCESCO MARIA EMILIA ,  JONES PHILIP ,  HEFFERNAN TIMOTHY ,  HAMILTON MATTHEW ,  KANG ZHIJUN ,  SOTH MICHAEL P ,  BURKE JASON P ,  LE KANG ,  CARROLL CHRISTOPHER LAWRENCE ,  PALMER WYLIE ,  LEWIS RICHARD ,  MCAFOOS TIMOTHY

IPC: C07D401/06 ,  A61K31/4439 ,  C07D417/14

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS I mediated diseases, such as cancer, having the structure of Formula I. Methods of inhibition GLS I activity in a human or animal subject are also provided. Accordingly, the inventors herein disclose new compositions and methods for inhibiting glutaminase activity. The present disclosure relates to new heterocyclic compounds and compositions, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of GLS 1 activity in a human or animal subject are also provided for the treatment of diseases such as cancer.