公开(公告)号：WO1998020931A1

公开(公告)日：1998-05-22

申请号：PCT/US1997020653

申请日：1997-11-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BRISTOL-MYERS SQUIBB COMPANY ,  HOLM, Niels, Erik ,  LINNEBJERG, Steven ,  CORNWELL, Richard

IPC: A61M31/00

CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  A61M35/00 ,  B05B7/08 ,  B05B7/0876

Abstract: Novel methods and devices which provide enhanced mixing, and application of two liquid components to form a biomaterial with minimized aerosols, are achieved using airflow rates below about 1.25 liters/minute in combination with a ratio of airflow to total liquid flow of from about 150:1 up to about 1500:1. Preferably the airflow is below about 1 liter/minute, and the ratio of airflow to total liquid flow is from about 200:1 to about 1200:1. The parameters are ideally suited for the spray application of components which form a surgical sealant, e.g., a fibrin sealant. Also a part of the present invention is novel application methods for biomaterial, e.g., surgical sealant, components at liquid flows below 1.9 ml/minute, novel methods involving the mixing of such components on the exit surface of a spray tip (14), or nozzle, novel spray tips (14), biomaterial applicators, and methods for making such applicators.

Abstract translation: 使用低于约1.25升/分钟的气流速率结合两个液体组分以形成具有最小气溶胶的生物材料的新方法和装置，结合气流与总液体流量的比例为约150:1， 1到1500：1。 优选地，气流低于约1升/分钟，并且气流与总液体流量的比率为约200:1至约1200:1。 这些参数非常适用于喷雾施用形成外科密封剂的组分，例如纤维蛋白封闭剂。 本发明的另一部分是用于生物材料的新型应用方法，例如手术密封剂，液体流速低于1.9ml /分钟的组分，涉及在喷嘴（14）的出口表面上混合这些组分的新方法，或 喷嘴，新型喷嘴（14），生物材料施加器以及制造这种涂敷器的方法。

公开(公告)号：WO1997020635A1

公开(公告)日：1997-06-12

申请号：PCT/US1996019506

申请日：1996-12-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BRISTOL-MYERS SQUIBB COMPANY ,  HOLM, Niels, Erik ,  CARR, Raymond ,  HVID, Niels ,  ANDERSEN, Louis ,  JORGENSEN, Jesper

IPC: B04B07/06

CPC classification number: B04B7/00 ,  B01D21/262 ,  B01D2221/10 ,  B04B2005/0485

Abstract: A centrifuge apparatus which comprises a container (10) including a cylindrical member (11) with a lower rim and a piston member with a tubular piston rod (12). A supporting turntable (1) with a first gripping means (27) releasably grips the lower rim when the container (10) is placed thereon, said supporting turntable (1) being connected with a first activating means (5) for rotating the turntable (1) with the container (10) about the central axis thereof. A rotatably journalled piston activating mechanism activates the piston (12) by a second activating means (21) and is provided with a second gripping means (13) for releasably gripping the piston rod (12). The first gripping means (27) enters into a locking engagement with the inner side of the cylindrical member (11) upon activation of a third activating means (8) when the container (10) is placed on the turntable (1). The second gripping means (13) enters into a locking engagement with the piston rod (12) upon activation of a fourth activating means (15).

Abstract translation: 一种离心机装置，其包括容器（10），容器（10）包括具有下边缘的圆柱形构件（11）和具有管状活塞杆（12）的活塞构件。 当容器（10）放置在其上时，具有第一夹持装置（27）的支撑转台（1）可释放地夹住下边缘，所述支撑转盘（1）与用于旋转转台的第一启动装置（5）连接 1）与容器（10）围绕其中心轴线。 可旋转的轴颈活塞启动机构通过第二启动装置（21）来启动活塞（12）并且设置有用于可释放地夹紧活塞杆（12）的第二夹紧装置（13）。 当容器（10）放置在转盘（1）上时，第一夹紧装置（27）在激活第三启动装置（8）时进入与圆柱形构件（11）的内侧的锁定接合。 第二夹持装置（13）在激活第四激活装置（15）时进入与活塞杆（12）的锁定接合。

公开(公告)号：WO1997020585A1

公开(公告)日：1997-06-12

申请号：PCT/US1996019505

申请日：1996-12-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BRISTOL-MYERS SQUIBB COMPANY ,  HOLM, Niels, Erik ,  GARBASCH, Allan ,  FAIRBROTHER, John, E. ,  CASTELLANA, Frank

IPC: A61M05/00

CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  B05B7/0869 ,  B05B7/2497

Abstract: A method of applying a mixture or two liquid components kept in their respective container (19) implies that the two components are expelled through their respective outlet (8, 9) of their respective outlet channel (5, 6) in a nozzle head (1) while a gas is simultaneously expelled through a separate outlet (10) in a gas outlet channel (7) in the nozzle head (1). The above outlets (8, 9, 10) are aligned along a substantially rectilinear line, the gas being expelled through the outlet (10) at one end of the line of outlets, and where the volume flow of the gas is adapted to the volume flows of the components in such a manner that outside the nozzle (1) said components are sucked into the jet being expelled through the gas outlet.

Abstract translation: 施加保持在其相应容器（19）中的混合物或两种液体组分的方法意味着两个组分通过其各自的出口通道（5,6）的相应出口（8,9）排出在喷嘴头（1）中 ），同时通过喷嘴头（1）中的气体出口通道（7）中的单独的出口（10）同时排出气体。 上述出口（8,9,10）沿着基本上直线的线排列，气体在出口线的一端通过出口（10）排出，并且其中气体的体积流量适应于体积 所述部件的流动使得喷嘴（1）的外部，所述部件被吸入喷射流中，通过气体出口排出。

公开(公告)号：EP0808203B1

公开(公告)日：2001-03-14

申请号：EP95943646.0

申请日：1995-12-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： HOLM, Niels, Erik

IPC: B01D21/26

CPC classification number: B04B1/02 ,  B01D21/262 ,  B01D2221/10 ,  B04B5/0442 ,  B04B2005/0485 ,  G01N33/491 ,  Y10T436/25375

Abstract: A device for separating components such as fibrin monomer from blood by centrifugation about a central axis comprising a first annular chamber (70) defined by an outer cylindrical wall (72) and an inner cylindrical wall (71) both walls being concentriclly accommodated about an axis of rotation, and by a top wall (73) and a bottom wall (74), where the bottom wall is formed by a piston (55) displlaceable within the first. The device furthermore comprises, a second chamber (75) below the first chamber and communicating with said first chamber through a first conduit (4) and being defined by the other cylindrical wall (72), the bottom wall (74) of the first chamber, and another bottom wall (76). The device also comprises a capsule (45) accommodated in the second chamber and including a plurality of compartments for receiving respective compositions promoting the separation.

公开(公告)号：EP0951311A1

公开(公告)日：1999-10-27

申请号：EP97946656.0

申请日：1997-11-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： HOLM, Niels, Erik ,  LINNEBJERG, Steven ,  CORNWELL, Richard

IPC: A61B17 ,  A61L26 ,  A61M31 ,  A61M35 ,  B05B7

CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  A61M35/00 ,  B05B7/08 ,  B05B7/0876

Abstract: Novel methods and devices which provide enhanced mixing, and application of two liquid components to form a biomaterial with minimized aerosols, are achieved using airflow rates below about 1.25 liters/minute in combination with a ratio of airflow to total liquid flow of from about 150:1 up to about 1500:1. Preferably the airflow is below about 1 liter/minute, and the ratio of airflow to total liquid flow is from about 200:1 to about 1200:1. The parameters are ideally suited for the spray application of components which form a surgical sealant, e.g., a fibrin sealant. Also a part of the present invention is novel application methods for biomaterial, e.g., surgical sealant, components at liquid flows below 1.9 ml/minute, novel methods involving the mixing of such components on the exit surface of a spray tip (14), or nozzle, novel spray tips (14), biomaterial applicators, and methods for making such applicators.

公开(公告)号：EP0794823A1

公开(公告)日：1997-09-17

申请号：EP95942532.0

申请日：1995-12-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： HOLM, Niels, Erik

IPC: A61K35 ,  B01D21 ,  B01J19 ,  B04B1 ,  B04B5

CPC classification number: B01D21/262 ,  B01D21/2405 ,  B01D21/2427 ,  B01D2221/10 ,  B04B1/02 ,  B04B5/0442 ,  B04B2005/0485 ,  Y10T137/87676 ,  Y10T436/111666 ,  Y10T436/25375

Abstract: A device for separating components such as fibrin monomer from blood by centrifugation about a central axis comprising a first annular chamber (70) defined by an outer cylindrical wall (72) and an inner cylindrical wall (71) both walls being concentrically accommodated about an axis of rotation, and by a top wall (73) and a bottom wall (74), where the bottom wall is formed by a piston (55) displaceable within the first chamber. The device including a second chamber (75) below the first chamber and communicating with the first chamber through a first conduit (4) and being defined by the outer cylindrical wall (72), the bottom wall (74) of the first chamber, and another bottom wall (76). The device also includes a capsule (45) accommodated in the second chamber and including a plurality of compartments for receiving respective compositions promoting the separation.

Abstract translation: 一种用于通过围绕中心轴离心从血液中分离诸如血纤维蛋白单体的组分的装置，该装置包括由外圆柱壁（72）和内圆柱壁（71）限定的第一环形腔室（70），两个壁围绕轴线同心地容纳 以及顶壁（73）和底壁（74），其中底壁由在第一腔室内可移动的活塞（55）形成。 该装置包括位于第一腔室下方并通过第一导管（4）与第一腔室连通并由外圆柱形壁（72），第一腔室的底壁（74）和第二腔室 另一底壁（76）。 该装置还包括容纳在第二腔室中的胶囊（45），并包括多个隔室，用于接收促进分离的相应组合物。

公开(公告)号：EP1003577A1

公开(公告)日：2000-05-31

申请号：EP98937106.7

申请日：1998-07-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： CARR, Raymond, A. ,  AMERY, Michael J. ,  HOLM, Niels, Erik

IPC: A61M5/00 ,  A61M37/00

CPC classification number: A61B17/00491 ,  A61B90/90 ,  A61B90/96 ,  A61M2205/60

Abstract: The present invention provides methods and devices for maintaining the integrity of blood products throughout preparation, processing and application to a patient or desired site. Coding means are incorporated onto or into processing and delivery containers which coding means contain information identifying the donor and/orrecipient. Additionally or alternatively the coding means may contain information pertaining to a specific preparation or application process to be carried out. Blood product processors and blood product applicators include decoding means to ensure the blood product is administered to the appropriate recipient and further that it has been prepared and applied according to desired processes.

公开(公告)号：EP0951311B1

公开(公告)日：2007-03-28

申请号：EP97946656.2

申请日：1997-11-14

Applicant: Bristol-Myers Squibb Company

Inventor： HOLM, Niels, Erik ,  LINNEBJERG, Steven ,  CORNWELL, Richard

IPC: A61M35/00 ,  A61B17/00 ,  A61M25/00 ,  A61M31/00

CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  A61M35/00 ,  B05B7/08 ,  B05B7/0876

Abstract: Novel methods and devices which provide enhanced mixing, and application of two liquid components to form a biomaterial with minimized aerosols, are achieved using airflow rates below about 1.25 liters/minute in combination with a ratio of airflow to total liquid flow of from about 150:1 up to about 1500:1. Preferably the airflow is below about 1 liter/minute, and the ratio of airflow to total liquid flow is from about 200:1 to about 1200:1. The parameters are ideally suited for the spray application of components which form a surgical sealant, e.g., a fibrin sealant. Also a part of the present invention is novel application methods for biomaterial, e.g., surgical sealant, components at liquid flows below 1.9 ml/minute, novel methods involving the mixing of such components on the exit surface of a spray tip (14), or nozzle, novel spray tips (14), biomaterial applicators, and methods for making such applicators.

公开(公告)号：EP0914212B1

公开(公告)日：2002-05-08

申请号：EP96943639.3

申请日：1996-12-06

Applicant: Bristol-Myers Squibb Company

Inventor： HOLM, Niels, Erik ,  CARR, Raymond ,  HVID, Niels ,  ANDERSEN, Louis ,  JORGENSEN, Jesper

IPC: B04B7/06 ,  B04B15/00

CPC classification number: B04B7/00 ,  B01D21/262 ,  B01D2221/10 ,  B04B2005/0485

Abstract: A centrifuge apparatus which comprises a container (10) including a cylindrical member (11) with a lower rim and a piston member with a tubular piston rod (12). A supporting turntable (1) with a first gripping means (27) releasably grips the lower rim when the container (10) is placed thereon, said supporting turntable (1) being connected with a first activating means (5) for rotating the turntable (1) with the container (10) about the central axis thereof. A rotatably journalled piston activating mechanism activates the piston (12) by a second activating means (21) and is provided with a second gripping means (13) for releasably gripping the piston rod (12). The first gripping means (27) enters into a locking engagement with the inner side of the cylindrical member (11) upon activation of a third activating means (8) when the container (10) is placed on the turntable (1). The second gripping means (13) enters into a locking engagement with the piston rod (12) upon activation of a fourth activating means (15).

公开(公告)号：EP0914212A1

公开(公告)日：1999-05-12

申请号：EP96943639.0

申请日：1996-12-06

Applicant: Bristol-Myers Squibb Company

Inventor： HOLM, Niels, Erik ,  CARR, Raymond ,  HVID, Niels ,  ANDERSEN, Louis ,  JORGENSEN, Jesper

IPC: B04B7 ,  B01D21 ,  B04B15

CPC classification number: B04B7/00 ,  B01D21/262 ,  B01D2221/10 ,  B04B2005/0485

Abstract: A centrifuge apparatus which comprises a container (10) including a cylindrical member (11) with a lower rim and a piston member with a tubular piston rod (12). A supporting turntable (1) with a first gripping means (27) releasably grips the lower rim when the container (10) is placed thereon, said supporting turntable (1) being connected with a first activating means (5) for rotating the turntable (1) with the container (10) about the central axis thereof. A rotatably journalled piston activating mechanism activates the piston (12) by a second activating means (21) and is provided with a second gripping means (13) for releasably gripping the piston rod (12). The first gripping means (27) enters into a locking engagement with the inner side of the cylindrical member (11) upon activation of a third activating means (8) when the container (10) is placed on the turntable (1). The second gripping means (13) enters into a locking engagement with the piston rod (12) upon activation of a fourth activating means (15).