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1.发明申请PYRAZOLOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION 审中-公开作为人免疫缺陷病毒复制的抑制剂的吡唑并嘧啶大环化合物
公开(公告)号：WO2015123182A1
公开(公告)日：2015-08-20
申请号：PCT/US2015/015154
申请日：2015-02-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： PEESE, Kevin , WANG, Zhongyu , LANGLEY, David, R. , KADOW, John, F. , NAIDU, Narasimhulu, B.
IPC: C07D471/22 , A61K31/519 , A61P31/18 , C07D495/22
CPC classification number: C07D513/22 , C07D471/22 , C07D498/22
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
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公开(公告)号：WO2008144380A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/063689
申请日：2008-05-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY , BACHAND, Carol , BELEMA, Makonen , DEON, Daniel, H. , GOOD, Andrew, C. , GOODRICH, Jason , HAMANN, Lawrence, G. , JAMES, Clint, A. , LANGLEY, David, R. , LAVOIE, Rico , LOPEZ, Omar, D. , MARTEL, Alain , MEANWELL, Nicholas, A. , NGUYEN, Van, N. , ROMINE, Jeffrey, Lee , RUEDIGER, Edward, H. , SNYDER, Lawrence, B. , ST. LAURENT, Denis, R. , YANG, Fukang , WANG, Gan
Inventor： BACHAND, Carol , BELEMA, Makonen , DEON, Daniel, H. , GOOD, Andrew, C. , GOODRICH, Jason , HAMANN, Lawrence, G. , JAMES, Clint, A. , LANGLEY, David, R. , LAVOIE, Rico , LOPEZ, Omar, D. , MARTEL, Alain , MEANWELL, Nicholas, A. , NGUYEN, Van, N. , ROMINE, Jeffrey, Lee , RUEDIGER, Edward, H. , SNYDER, Lawrence, B. , ST. LAURENT, Denis, R. , YANG, Fukang , WANG, Gan
IPC: C07D413/14 , C07D403/04 , C07D403/14 , A61K31/40 , A61P31/12
CPC classification number: C07D413/14 , C07D403/04 , C07D403/14
Abstract: The present disclosure relates to compounds of the following formula (I) or a pharmaceutically acceptable salt thereof, wherein A and B are each phenyl; D and E are each five-membered aromatic rings containing one, two, or three i hcteroatoms independently selected from nitrogen, oxygen, and sulfur; provided that ', at least one of D and E is other than imidazole; compositions and methods for the treatment of Hepatitis C virus (HCV) inf ection. Also disclosed are pharmaceutical compositions containing such compounds and methods f or using these compounds in the treatment of HCV inf ection.
Abstract translation: 本公开涉及下式（I）的化合物或其药学上可接受的盐，其中A和B各自为苯基; D和E分别是含有独立地选自氮，氧和硫的一个，两个或三个独立原子的五元芳环; 条件是'，D和E中的至少一个不是咪唑; 用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和f或使用这些化合物治疗HCV感染的方法。
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公开(公告)号：WO2018085750A3
公开(公告)日：2018-05-11
申请号：PCT/US2017/060107
申请日：2017-11-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： GILLMAN, Kevin, W. , GOODRICH, Jason , LANGLEY, David, R. , SCOLA, Paul Michael
Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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公开(公告)号：WO2018085750A2
公开(公告)日：2018-05-11
申请号：PCT/US2017/060107
申请日：2017-11-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： GILLMAN, Kevin, W. , GOODRICH, Jason , LANGLEY, David, R. , SCOLA, Paul Michael
Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Abstract translation: 本公开提供了作为免疫调节剂的化合物，因此可用于改善各种疾病，包括癌症和感染性疾病。
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公开(公告)号：WO2009102318A1
公开(公告)日：2009-08-20
申请号：PCT/US2008/053638
申请日：2008-02-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY , BACHAND, Carol , BELEMA, Makonen , DEON, Daniel, H. , GOOD, Andrew, C. , GOODRICH, Jason , JAMES, Clint, A. , LAVOIE, Rico , LOPEZ, Omar, D. , MARTEL, Alain , MEANWELL, Nicholas, A. , NGUYEN, Van N. , ROMINE, Jeffrey, Lee , RUEDIGER, Edward, H. , SNYDER, Lawrence, B. , ST. LAURENT, Denis, R. , YANG, Fukang , LANGLEY, David, R. , WANG, Gan , HAMANN, Lawrence, G.
Inventor： BACHAND, Carol , BELEMA, Makonen , DEON, Daniel, H. , GOOD, Andrew, C. , GOODRICH, Jason , JAMES, Clint, A. , LAVOIE, Rico , LOPEZ, Omar, D. , MARTEL, Alain , MEANWELL, Nicholas, A. , NGUYEN, Van N. , ROMINE, Jeffrey, Lee , RUEDIGER, Edward, H. , SNYDER, Lawrence, B. , ST. LAURENT, Denis, R. , YANG, Fukang , LANGLEY, David, R. , WANG, Gan , HAMANN, Lawrence, G.
IPC: C07D403/10 , C07D403/14 , A61K31/4164 , A61P31/22
CPC classification number: C07D403/14 , C07D233/64 , C07D403/10
Abstract: The present disclosure relates to (4-4' -diimidazolyl) biphenyls compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
Abstract translation: 本公开涉及（4-4'-二咪唑基）联苯组合物和治疗丙型肝炎病毒（HCV）感染的方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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Patent Agency Ranking
公开(公告)号：WO2008021936A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/075553
申请日：2007-08-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY , BACHAND, Carol , BELEMA, Makonen , DEON, Daniel, H. , GOOD, Andrew, C. , GOODRICH, Jason , JAMES, Clint, A. , LAVOIE, Rico , LOPEZ, Omar, D. , MARTEL, Alain , MEANWELL, Nicholas, A. , NGUYEN, Van, N. , ROMINE, Jeffrey Lee , RUEDIGER, Edward, H. , SNYDER, Lawrence, B. , ST. LAURENT, Denis, R. , YANG, Fukang , LANGLEY, David, R. , HAMANN, Lawrence, G.
Inventor： BACHAND, Carol , BELEMA, Makonen , DEON, Daniel, H. , GOOD, Andrew, C. , GOODRICH, Jason , JAMES, Clint, A. , LAVOIE, Rico , LOPEZ, Omar, D. , MARTEL, Alain , MEANWELL, Nicholas, A. , NGUYEN, Van, N. , ROMINE, Jeffrey Lee , RUEDIGER, Edward, H. , SNYDER, Lawrence, B. , ST. LAURENT, Denis, R. , YANG, Fukang , LANGLEY, David, R. , HAMANN, Lawrence, G.
IPC: A61K31/501 , A61K31/506 , A61K31/497 , A61P31/12
CPC classification number: C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。
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7.发明申请CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES 审中-公开CYPOTOXIC AMINO糖及其相关糖衍生物
公开(公告)号：WO1998007433A1
公开(公告)日：1998-02-26
申请号：PCT/US1997014738
申请日：1997-08-21
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： BRISTOL-MYERS SQUIBB COMPANY , SAULNIER, Mark, George , BALASUBRAMANIAN, Neelakantan , FRENNESSON, David, Bertil , ST. LAURENT, Denis, R. , LANGLEY, David, R.
IPC: A61K31/70
CPC classification number: C07H17/02 , Y02P20/582
Abstract: The present invention concerns novel amino sugar and related sugar derivatives of indolopyrrolocarbazoles, their use as antitumor agents, and pharmaceutical formulations.
Abstract translation: 本发明涉及吲哚吡咯并唑的新型氨基糖和相关糖衍生物，它们作为抗肿瘤剂的用途和药物制剂。
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8.发明申请CONFORMATIONALLY RESTRICTED BIPHENYL DERIVATIVES FOR USE AS HEPATITIS C VIRUS INHIBITORS 审中-公开用作乙型肝炎病毒抑制剂的连续限制性联苯衍生物
公开(公告)号：WO2009102568A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/032830
申请日：2009-02-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY , BACHAND, Carol , BELEMA, Makonen , DEON, Daniel, H. , GOOD, Andrew, C. , GOODRICH, Jason , JAMES, Clint, A. , LAVOIE, Rico , LOPEZ, Omar, D. , MARTEL, Alain , MEANWELL, Nicholas, A. , NGUYEN, Van, N. , ROMINE, Jeffrey, Lee , RUEDIGER, Edward, H. , SNYDER, Lawrence, B. , ST. LAURENT, Denis, R. , YANG, Fukang , LANGLEY, David, R. , WANG, Gan , HAMANN, Lawrence, G.
Inventor： BACHAND, Carol , BELEMA, Makonen , DEON, Daniel, H. , GOOD, Andrew, C. , GOODRICH, Jason , JAMES, Clint, A. , LAVOIE, Rico , LOPEZ, Omar, D. , MARTEL, Alain , MEANWELL, Nicholas, A. , NGUYEN, Van, N. , ROMINE, Jeffrey, Lee , RUEDIGER, Edward, H. , SNYDER, Lawrence, B. , ST. LAURENT, Denis, R. , YANG, Fukang , LANGLEY, David, R. , WANG, Gan , HAMANN, Lawrence, G.
IPC: C07D403/14 , C07D405/14 , A61K31/4178 , A61P31/14
CPC classification number: C07D403/14 , C07D405/14
Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号：WO2009015254A1
公开(公告)日：2009-01-29
申请号：PCT/US2008/070961
申请日：2008-07-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY , VELAPARTHI, Upender , LIU, Peiying , WITTMAN, Mark, D. , LANGLEY, David, R.
Inventor： VELAPARTHI, Upender , LIU, Peiying , WITTMAN, Mark, D. , LANGLEY, David, R.
IPC: A61P35/00 , A61K31/395 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/08 , C07D491/08
CPC classification number: C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D487/08 , C07D491/08 , C07D493/08
Abstract: The invention provides compounds of formula: (I); and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents.
Abstract translation: 本发明提供式（I）化合物： 及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂。
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公开(公告)号：WO2016077518A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/060265
申请日：2015-11-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： GILLMAN, Kevin W. , GOODRICH, Jason , BOY, Kenneth M. , ZHANG, Yunhui , MAPELLI, Claudio , POSS, Michael A. , SUN, Li-Qiang , ZHAO, Qian , MULL, Eric , GILLIS, Eric P. , SCOLA, Paul Michael , LANGLEY, David, R.
CPC classification number: C07K7/08 , A61K38/00 , A61K38/10 , A61K45/06 , A61K51/088 , C07K7/56 , Y02A50/463
Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Abstract translation: 本公开提供了作为免疫调节剂的化合物，因此可用于改善各种疾病，包括癌症和感染性疾病。
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