公开(公告)号：WO2013138436A1

公开(公告)日：2013-09-19

申请号：PCT/US2013/030772

申请日：2013-03-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WANG, Tao ,  KADOW, John, F. ,  MEANWELL, Nicholas, A. ,  HAMANN, Lawrence, G.

IPC: C07D471/04 ,  A61K31/501 ,  A61K31/519 ,  A61K31/18

CPC classification number: C07D471/04 ,  A61K31/501 ,  A61K31/519 ,  A61K45/06 ,  C07D519/00

Abstract: Compounds of Formula I are provided, including pharmaceutically acceptable salts thereof: wherein A is selected from the group consisting of: wherein Z is selected from the group consisting of: which are useful as HIV attachment inhibitors.

Abstract translation: 提供了式I化合物，包括其药学上可接受的盐：其中A选自：其中Z选自：其可用作HIV附着抑制剂。

公开(公告)号：WO2012033735A1

公开(公告)日：2012-03-15

申请号：PCT/US2011/050503

申请日：2011-09-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  PENDRI, Annapurna ,  LI, Guo ,  GERRITZ, Samuel ,  LANGLEY, David, R. ,  TRAINOR, George, L. ,  MEANWELL, Nicholas, A.

Inventor： PENDRI, Annapurna ,  LI, Guo ,  GERRITZ, Samuel ,  LANGLEY, David, R. ,  TRAINOR, George, L. ,  MEANWELL, Nicholas, A.

IPC: C07D487/04 ,  A61K31/519 ,  A61P31/18

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  C07D519/00 ,  A61K2300/00

Abstract: The disclosure generally relates to compounds of formula (I), including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

Abstract translation: 本发明一般涉及式（I）化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。

公开(公告)号：WO2012019003A1

公开(公告)日：2012-02-09

申请号：PCT/US2011/046589

申请日：2011-08-04

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  WANG, Tao ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  KADOW, John, F. ,  MEANWELL, Nicholas, A.

Inventor： WANG, Tao ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  KADOW, John, F. ,  MEANWELL, Nicholas, A.

IPC: C07D209/40 ,  C07D401/06 ,  C07D471/04 ,  C07F5/02 ,  A61K31/437 ,  A61P31/00

CPC classification number: C07D401/06 ,  A61K31/437 ,  C07D209/40 ,  C07D471/04 ,  C07F5/025

Abstract: Compounds having drug and bio-affecting properties are described herein, including their properties, pharmaceutical compositions and methods of use. In particular, tricyclic aryl or heteroaryl piperazine diamide derivatives that possess unique antiviral activity are set forth. These compounds are useful for the treatment of HIV and AIDS. The compounds herein have the general Formula I:(Formula I should be inserted here) wherein: Y is selected from the group of indole or azaindole systems:(Formula Y should be inserted here) and Z is selected from the group of:(Formula Z should be inserted here)

Abstract translation: 本文描述了具有药物和生物影响特性的化合物，包括其性质，药物组合物和使用方法。 特别地，阐述了具有独特抗病毒活性的三环芳基或杂芳基哌嗪二酰胺衍生物。 这些化合物可用于治疗艾滋病毒和艾滋病。 本文中的化合物具有通式I：（式I应该在此插入），其中：Y选自吲哚或氮杂吲哚系：（式Y应在此插入），Z选自：式 Z应该插入这里）

公开(公告)号：WO2008111978A1

公开(公告)日：2008-09-18

申请号：PCT/US2007/063885

申请日：2007-03-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  MEANWELL, Nicholas, A. ,  GENTLES, Robert G. ,  DING, Min ,  BENDER, John A. ,  KADOW, John F. ,  HEWAWASAM, Piyasena ,  HUDYMA, Thomas W. ,  ZHENG, Xiaofan

Inventor： MEANWELL, Nicholas, A. ,  GENTLES, Robert G. ,  DING, Min ,  BENDER, John A. ,  KADOW, John F. ,  HEWAWASAM, Piyasena ,  HUDYMA, Thomas W. ,  ZHENG, Xiaofan

IPC: C07D487/04 ,  A61P31/12 ,  A61K31/55

CPC classification number: C07D487/04

Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Formula (I).

Abstract translation: 本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。 式（I）。

公开(公告)号：WO2008021928A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075545

申请日：2007-08-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  JAMES, Clint, A. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  LANGLEY, David, R. ,  HAMANN, Lawrence, G.

IPC: A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  A61K31/444 ,  A61K31/4439 ,  A61P31/12 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D401/14 ,  C07D403/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

公开(公告)号：WO2012075235A1

公开(公告)日：2012-06-07

申请号：PCT/US2011/062804

申请日：2011-12-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  WANG, Tao ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  KADOW, John, F. ,  MEANWELL, Nicholas, A.

Inventor： WANG, Tao ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  KADOW, John, F. ,  MEANWELL, Nicholas, A.

IPC: C07D471/04 ,  A61K31/437 ,  A61P31/18

CPC classification number: C07D471/04

Abstract: Compounds of Formula (I), including pharmaceutically acceptable salts thereof, wherein A is selected from the group (II), are useful as HIV attachment inhibitors.

Abstract translation: 式（I）化合物，包括其药学上可接受的盐，其中A选自（II）组，可用作HIV附着抑制剂。

公开(公告)号：WO2008144380A1

公开(公告)日：2008-11-27

申请号：PCT/US2008/063689

申请日：2008-05-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  HAMANN, Lawrence, G. ,  JAMES, Clint, A. ,  LANGLEY, David, R. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  WANG, Gan

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  HAMANN, Lawrence, G. ,  JAMES, Clint, A. ,  LANGLEY, David, R. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  WANG, Gan

IPC: C07D413/14 ,  C07D403/04 ,  C07D403/14 ,  A61K31/40 ,  A61P31/12

CPC classification number: C07D413/14 ,  C07D403/04 ,  C07D403/14

Abstract: The present disclosure relates to compounds of the following formula (I) or a pharmaceutically acceptable salt thereof, wherein A and B are each phenyl; D and E are each five-membered aromatic rings containing one, two, or three i hcteroatoms independently selected from nitrogen, oxygen, and sulfur; provided that ', at least one of D and E is other than imidazole; compositions and methods for the treatment of Hepatitis C virus (HCV) inf ection. Also disclosed are pharmaceutical compositions containing such compounds and methods f or using these compounds in the treatment of HCV inf ection.

Abstract translation: 本公开涉及下式（I）的化合物或其药学上可接受的盐，其中A和B各自为苯基; D和E分别是含有独立地选自氮，氧和硫的一个，两个或三个独立原子的五元芳环; 条件是'，D和E中的至少一个不是咪唑; 用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和f或使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2005046712A1

公开(公告)日：2005-05-26

申请号：PCT/US2004/038165

申请日：2004-11-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  SCOLA, Paul, Michael ,  MCPHEE, Fiona ,  MEANWELL, Nicholas, A. ,  HEWAWASAM, Piyasena ,  CAMPBELL, Jeffrey, Allen

Inventor： SCOLA, Paul, Michael ,  MCPHEE, Fiona ,  MEANWELL, Nicholas, A. ,  HEWAWASAM, Piyasena ,  CAMPBELL, Jeffrey, Allen

IPC: A61K38/06

CPC classification number: C07K5/0808 ,  A61K38/00 ,  C07K5/0802

Abstract: Compounds are disclosed having general formula (I), wherein R 1 , R 2 , R 3 , R 4 , R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Abstract translation: 公开了具有通式（I）的化合物，其中在说明书中描述了R1，R2，R3，R4，R'，B，Y和X. 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

公开(公告)号：WO2004043337A2

公开(公告)日：2004-05-27

申请号：PCT/US2003/013324

申请日：2003-04-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WANG, Tao ,  KADOW, John, F. ,  MEANWELL, Nicholas, A. ,  YEUNG, Kap-Sun ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  QIU, Zhilei ,  DEON, Daniel, H. ,  JAMES, Clint, A. ,  RUEDIGER, Edward, H. ,  BACHAND, Carol

IPC: A61K

CPC classification number: C07D413/14 ,  C07D401/06 ,  C07D471/04

Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: (I) wherein: Z is ; Q is selected from the group consisting of: ; -W-is .

Abstract translation: 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别是，本发明涉及具有独特的抗病毒活性的新的哌啶4-链烯基衍生物。 更具体地说，本发明涉及可用于治疗HIV和AIDS的化合物。 通式I的本发明化合物：（I）其中：Z是; Q选自由以下组成的组： -W-是。

公开(公告)号：WO2003068221A1

公开(公告)日：2003-08-21

申请号：PCT/US2003/002692

申请日：2003-01-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： KADOW, John, F. ,  XUE, Qiufen, May ,  WANG, Tao ,  ZHANG, Zhongxing ,  MEANWELL, Nicholas, A.

IPC: A61K31/404

CPC classification number: C07D403/06 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D471/04

Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

Abstract translation: 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及酰胺哌嗪衍生物。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。