公开(公告)号：WO2014025852A1

公开(公告)日：2014-02-13

申请号：PCT/US2013/053901

申请日：2013-08-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WANG, Tao ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  RUEDIGER, Edward H. ,  JAMES, Clint A. ,  DEON, Daniel H.

IPC: C07D401/14 ,  C07D401/06 ,  C07D471/04 ,  A61K31/437 ,  A61K31/454 ,  A61K31/4545 ,  A61P31/18

CPC classification number: A61K31/4545 ,  A61K31/454 ,  A61K45/06 ,  C07D401/06 ,  C07D401/14 ,  C07D471/04

Abstract: Compounds of Formula (I), including pharmaceutically acceptable salts thereof: wherein A is selected from the group consisting of: and wherein Z is: are useful as HIV attachment inhibitors.

Abstract translation: 式（I）的化合物，包括其药学上可接受的盐：其中A选自：和其中Z是：可用作HIV附着抑制剂。

公开(公告)号：WO2012075235A1

公开(公告)日：2012-06-07

申请号：PCT/US2011/062804

申请日：2011-12-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  WANG, Tao ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  KADOW, John, F. ,  MEANWELL, Nicholas, A.

Inventor： WANG, Tao ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  KADOW, John, F. ,  MEANWELL, Nicholas, A.

IPC: C07D471/04 ,  A61K31/437 ,  A61P31/18

CPC classification number: C07D471/04

Abstract: Compounds of Formula (I), including pharmaceutically acceptable salts thereof, wherein A is selected from the group (II), are useful as HIV attachment inhibitors.

Abstract translation: 式（I）化合物，包括其药学上可接受的盐，其中A选自（II）组，可用作HIV附着抑制剂。

公开(公告)号：WO2007041616A1

公开(公告)日：2007-04-12

申请号：PCT/US2006/038731

申请日：2006-10-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  WANG, Tao ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  JAMES, Clint A. ,  RUEDIGER, Edward H. ,  PEARCE, Bradley C.

Inventor： WANG, Tao ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  JAMES, Clint A. ,  RUEDIGER, Edward H. ,  PEARCE, Bradley C.

IPC: C07D209/12 ,  C07D401/04 ,  C07D409/04 ,  C07D417/04 ,  C07D471/04 ,  C07F5/02 ,  A61K31/395 ,  A61P31/12 ,  A61P31/18

CPC classification number: C07D471/04 ,  C07D209/12 ,  C07D209/18 ,  C07D401/04 ,  C07D401/12 ,  C07D409/04 ,  C07D417/04 ,  C07F5/025

Abstract: This disclosure provides compounds of Formula (I) as described herein having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with indole and azaindole piperazine diamide derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS. Formula (I) wherein: X is selected from the group consisting of formulae (II, III, IV and V); Y is formula (VI); Z is formula (VII).

Abstract translation: 本公开内容提供了本文所述的具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本公开涉及具有独特抗病毒活性的吲哚和氮杂吲哚哌嗪二酰胺衍生物。 更具体地，本公开涉及可用于治疗HIV和AIDS的化合物。 式（I）其中：X选自式（II，III，IV和V）; Y是式（VI）; Z是式（VII）。

公开(公告)号：WO2004043337A2

公开(公告)日：2004-05-27

申请号：PCT/US2003/013324

申请日：2003-04-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WANG, Tao ,  KADOW, John, F. ,  MEANWELL, Nicholas, A. ,  YEUNG, Kap-Sun ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  QIU, Zhilei ,  DEON, Daniel, H. ,  JAMES, Clint, A. ,  RUEDIGER, Edward, H. ,  BACHAND, Carol

IPC: A61K

CPC classification number: C07D413/14 ,  C07D401/06 ,  C07D471/04

Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: (I) wherein: Z is ; Q is selected from the group consisting of: ; -W-is .

Abstract translation: 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别是，本发明涉及具有独特的抗病毒活性的新的哌啶4-链烯基衍生物。 更具体地说，本发明涉及可用于治疗HIV和AIDS的化合物。 通式I的本发明化合物：（I）其中：Z是; Q选自由以下组成的组： -W-是。

公开(公告)号：WO2016133972A1

公开(公告)日：2016-08-25

申请号：PCT/US2016/018184

申请日：2016-02-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WANG, Tao ,  YIN, Zhiwei ,  KADOW, John F.

IPC: C07D307/84 ,  A61K31/343 ,  A61P1/16 ,  A61P3/14

CPC classification number: C07D307/84 ,  C07D405/12 ,  C07D407/12 ,  C07F9/65517 ,  C07H7/06

Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV:

Abstract translation: 阐述了式I化合物，包括它们的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者：

公开(公告)号：WO2015143256A1

公开(公告)日：2015-09-24

申请号：PCT/US2015/021640

申请日：2015-03-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WANG, Tao ,  YIN, Zhiwei ,  KADOW, John F.

IPC: C07D405/10 ,  C07D413/10 ,  C07D307/84 ,  A61K31/506 ,  A61K31/343 ,  A61P31/14

CPC classification number: C07D405/10 ,  A61K31/343 ,  A61K31/506 ,  C07D307/84 ,  C07D413/10

Abstract: Compounds of Formula (I), including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV: (I)

Abstract translation: 阐述了式（I）化合物，包括它们的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者：（I）

公开(公告)号：WO2015126743A1

公开(公告)日：2015-08-27

申请号：PCT/US2015/015758

申请日：2015-02-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： NAIDU, B. Narasimhulu ,  WANG, Tao ,  PEESE, Kevin ,  YIN, Zhiwei ,  ZHANG, Zhongxing ,  KADOW, John F. ,  PATEL, Manoj

IPC: C07D498/16 ,  C07D498/22 ,  A61K31/519 ,  A61P31/18

CPC classification number: C07D498/16 ,  A61K31/519 ,  A61K45/06 ,  C07D498/22

Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV整合酶的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。

公开(公告)号：WO2014138239A1

公开(公告)日：2014-09-12

申请号：PCT/US2014/020759

申请日：2014-03-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WANG, Tao ,  YIN, Zhiwei ,  SCOLA, Paul Michael

IPC: C07D498/22 ,  A61K31/53 ,  A61P31/14

CPC classification number: C07D498/08 ,  A61K31/53 ,  A61K45/06

Abstract: The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供了式I的化合物，包括其药学上可接受的盐，以及使用该化合物的组合物和方法。 这些化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：WO2014116768A1

公开(公告)日：2014-07-31

申请号：PCT/US2014/012639

申请日：2014-01-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WANG, Tao ,  ZHANG, Zhongxing ,  HAN, Ying ,  YIN, Zhiwei ,  SCOLA, Paul Michael

IPC: C07D403/12 ,  A61K31/53 ,  C07D403/14 ,  C07D251/52 ,  A61P31/14

CPC classification number: A61K31/53 ,  A61K31/551 ,  A61K45/06 ,  C07D251/52 ,  C07D403/12 ,  C07D403/14

Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof, are set forth, in addition to compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 除了使用这些化合物的组合物和方法之外，还列举了式I化合物，包括其药学上可接受的盐。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：WO2012019003A1

公开(公告)日：2012-02-09

申请号：PCT/US2011/046589

申请日：2011-08-04

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  WANG, Tao ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  KADOW, John, F. ,  MEANWELL, Nicholas, A.

Inventor： WANG, Tao ,  ZHANG, Zhongxing ,  YIN, Zhiwei ,  KADOW, John, F. ,  MEANWELL, Nicholas, A.

IPC: C07D209/40 ,  C07D401/06 ,  C07D471/04 ,  C07F5/02 ,  A61K31/437 ,  A61P31/00

CPC classification number: C07D401/06 ,  A61K31/437 ,  C07D209/40 ,  C07D471/04 ,  C07F5/025

Abstract: Compounds having drug and bio-affecting properties are described herein, including their properties, pharmaceutical compositions and methods of use. In particular, tricyclic aryl or heteroaryl piperazine diamide derivatives that possess unique antiviral activity are set forth. These compounds are useful for the treatment of HIV and AIDS. The compounds herein have the general Formula I:(Formula I should be inserted here) wherein: Y is selected from the group of indole or azaindole systems:(Formula Y should be inserted here) and Z is selected from the group of:(Formula Z should be inserted here)

Abstract translation: 本文描述了具有药物和生物影响特性的化合物，包括其性质，药物组合物和使用方法。 特别地，阐述了具有独特抗病毒活性的三环芳基或杂芳基哌嗪二酰胺衍生物。 这些化合物可用于治疗艾滋病毒和艾滋病。 本文中的化合物具有通式I：（式I应该在此插入），其中：Y选自吲哚或氮杂吲哚系：（式Y应在此插入），Z选自：式 Z应该插入这里）