公开(公告)号：US20230091740A1

公开(公告)日：2023-03-23

申请号：US17904516

申请日：2020-02-26

Applicant: C.R. Bard, Inc.

Inventor： Robert Burgmeier ,  Cyal Lecy

IPC: A61F2/07 ,  A61L31/18 ,  A61L31/14 ,  A61L31/04 ,  C08L27/18 ,  C08L65/04

Abstract: In an embodiment, a method of producing a radiopaque stent graft is provided. The method may include functionalizing a surface of a coating layer of a stent graft to produce a functionalized surface; disposing a tie layer over the functionalized exterior surface of the stent graft; disposing an adherent layer over the tie layer; etching a slot into the adherent layer; functionalizing the slot; and positioning a radiopaque marker in the slot to produce a filled slot and thereby produce the radiopaque stent graft.

公开(公告)号：US20210052499A1

公开(公告)日：2021-02-25

申请号：US16913314

申请日：2020-06-26

Applicant: C.R. Bard, Inc.

Inventor： Elena Afonina ,  Hiep Do ,  Emily Goel ,  Oleg Guryev ,  Cyal Lecy ,  Majid Mehrpouyan ,  Michael Randall ,  Marybeth Sharkey ,  Jeffrey Wang

IPC: A61K9/16 ,  A61K31/4412 ,  A61K31/704 ,  A61K9/14 ,  A61K9/127 ,  A61K9/19

Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.

公开(公告)号：US20230181456A1

公开(公告)日：2023-06-15

申请号：US18159408

申请日：2023-01-25

Applicant: C.R. Bard, Inc.

Inventor： Elena Afonina ,  Hiep Do ,  Emily Goel ,  Oleg Guryev ,  Cyal Lecy ,  Majid Mehrpouyan ,  Michael Randall ,  Marybeth Sharkey ,  Jeffrey Wang

IPC: A61K9/00 ,  A61K9/127

CPC classification number: A61K9/0019 ,  A61K9/127

Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.

公开(公告)号：US11590080B2

公开(公告)日：2023-02-28

申请号：US16913314

申请日：2020-06-26

Applicant: C.R. Bard, Inc.

Inventor： Elena Afonina ,  Hiep Do ,  Emily Goel ,  Oleg Guryev ,  Cyal Lecy ,  Majid Mehrpouyan ,  Michael Randall ,  Marybeth Sharkey ,  Jeffrey Wang

IPC: A61K9/16 ,  A61K31/4412 ,  A61K9/19 ,  A61K9/14 ,  A61K9/127 ,  A61K31/704

Abstract: Drug-loaded microbead compositions include microbeads of a biodegradable material and vesicular agents located within or associated with the biodegradable material of the microbeads. The vesicular agents include a lipid bilayer and comprise liposomes or ethosomes. The drug-loaded microbeads include a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.