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公开(公告)号：US20210052499A1
公开(公告)日：2021-02-25
申请号：US16913314
申请日：2020-06-26
Applicant: C.R. Bard, Inc.
Inventor： Elena Afonina , Hiep Do , Emily Goel , Oleg Guryev , Cyal Lecy , Majid Mehrpouyan , Michael Randall , Marybeth Sharkey , Jeffrey Wang
IPC: A61K9/16 , A61K31/4412 , A61K31/704 , A61K9/14 , A61K9/127 , A61K9/19
Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.
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2.发明公开公开(公告)号：US20230181456A1
公开(公告)日：2023-06-15
申请号：US18159408
申请日：2023-01-25
Applicant: C.R. Bard, Inc.
Inventor： Elena Afonina , Hiep Do , Emily Goel , Oleg Guryev , Cyal Lecy , Majid Mehrpouyan , Michael Randall , Marybeth Sharkey , Jeffrey Wang
CPC classification number: A61K9/0019 , A61K9/127
Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.
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Patent Agency Ranking
3.发明授权公开(公告)号：US11590080B2
公开(公告)日：2023-02-28
申请号：US16913314
申请日：2020-06-26
Applicant: C.R. Bard, Inc.
Inventor： Elena Afonina , Hiep Do , Emily Goel , Oleg Guryev , Cyal Lecy , Majid Mehrpouyan , Michael Randall , Marybeth Sharkey , Jeffrey Wang
IPC: A61K9/16 , A61K31/4412 , A61K9/19 , A61K9/14 , A61K9/127 , A61K31/704
Abstract: Drug-loaded microbead compositions include microbeads of a biodegradable material and vesicular agents located within or associated with the biodegradable material of the microbeads. The vesicular agents include a lipid bilayer and comprise liposomes or ethosomes. The drug-loaded microbeads include a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.
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公开(公告)号：US20220000459A1
公开(公告)日：2022-01-06
申请号：US17428797
申请日：2019-02-15
Applicant: C.R. Bard, Inc.
Inventor： Hiep Do , Jordan Addison
Abstract: A hemostatic biopsy tract article includes a bioresorbable body having a microporous structure. The bioresorbable body is formed by a mixture that includes a bioabsorbable hemostatic powder, a hydrolyzed starch, hyaluronic acid, and carboxymethylcellulose. Optionally, a marker element may be coupled to the bioresorbable body, wherein the marker element is formed from a material that is imageable under at least one imaging modality.
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公开(公告)号：US20230172859A1
公开(公告)日：2023-06-08
申请号：US18165597
申请日：2023-02-07
Applicant: C.R. Bard, Inc.
Inventor： Hiep Do , Michael Randall
IPC: A61K9/16 , A61K9/00 , A61K31/351
CPC classification number: A61K9/1652 , A61K9/0019 , A61K9/1635 , A61K9/1647 , A61K9/1682 , A61K31/351
Abstract: Methods for preparing a drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. The drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. The therapeutic agent is not chemically bonded to the water-swellable polymer material. The drug-loaded microbead composition has a water content of less than 1% by weight, based on the total weight of the drug-loaded microbead composition. The drug-loaded microbead composition may be rehydrated to form an embolization composition for use in in embolization therapy.
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公开(公告)号：US11607388B2
公开(公告)日：2023-03-21
申请号：US16955275
申请日：2018-12-18
Applicant: C.R. Bard, Inc.
Inventor： Hiep Do , Michael Randall
IPC: A61K9/16 , A61K9/00 , A61K31/351
Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. The therapeutic agent is not chemically bonded to the water-swellable polymer material. The drug-loaded microbead composition has a water content of less than 1% by weight, based on the total weight of the drug-loaded microbead composition. The drug-loaded microbead composition may be rehydrated to form an embolization composition for use in in embolization therapy. Methods for preparing the drug-loaded microbead compositions and the embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads.
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公开(公告)号：US11464959B2
公开(公告)日：2022-10-11
申请号：US16323925
申请日：2017-09-08
Applicant: C.R. BARD, INC.
Inventor： Hiep Do
Abstract: A method and apparatus are aimed to improve arteriovenous fistula maturation rate by treating the fistula with a crosslink agent solution (fixative solution). The fixative solution will crosslink proteins and biomolecules, allowing formation of crosslinks that stabilize or stable tissue structure. The method and apparatus will address factors that contribute to arteriovenous fistula maturation failure by stopping the neointimal hyperplasia growth after vascular injury and stabilizing the venous wall to prevent the lumen from narrowing.
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