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公开(公告)号：US20180177515A1
公开(公告)日：2018-06-28
申请号：US15388335
申请日：2016-12-22
Applicant: C.R. Bard, Inc.
Inventor： Kevin Boyle , Andrzej J. Chanduszko , Michael Randall , Peng Zheng
Abstract: A catheter includes a wave guide for transmitting ultrasonic energy from a transducer, and which is also rotated to facilitate enhanced disruption of the concerned obstruction in a transverse direction. Embodiments of waveguide include distal anchors that help focus the energy transmitted to a treatment site, and may also include a deployable filter that may open distal of the obstruction to capture any dislodged debris. Selectively inflatable balloons may cordon off a treatment site, and the wave guide may comprise a tube that may serve the dual purposes of inflating the balloon(s), as well as to transmit ultrasonic energy to an obstruction. A portion of an ultrasonic catheter may include plural curved portions to space an exposed portion of the wave guide away from the catheter body to enhance the vibratory action provided.
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公开(公告)号：US20230172859A1
公开(公告)日：2023-06-08
申请号：US18165597
申请日：2023-02-07
Applicant: C.R. Bard, Inc.
Inventor： Hiep Do , Michael Randall
IPC: A61K9/16 , A61K9/00 , A61K31/351
CPC classification number: A61K9/1652 , A61K9/0019 , A61K9/1635 , A61K9/1647 , A61K9/1682 , A61K31/351
Abstract: Methods for preparing a drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. The drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. The therapeutic agent is not chemically bonded to the water-swellable polymer material. The drug-loaded microbead composition has a water content of less than 1% by weight, based on the total weight of the drug-loaded microbead composition. The drug-loaded microbead composition may be rehydrated to form an embolization composition for use in in embolization therapy.
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公开(公告)号：US11607388B2
公开(公告)日：2023-03-21
申请号：US16955275
申请日：2018-12-18
Applicant: C.R. Bard, Inc.
Inventor： Hiep Do , Michael Randall
IPC: A61K9/16 , A61K9/00 , A61K31/351
Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. The therapeutic agent is not chemically bonded to the water-swellable polymer material. The drug-loaded microbead composition has a water content of less than 1% by weight, based on the total weight of the drug-loaded microbead composition. The drug-loaded microbead composition may be rehydrated to form an embolization composition for use in in embolization therapy. Methods for preparing the drug-loaded microbead compositions and the embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads.
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公开(公告)号：US20220401239A1
公开(公告)日：2022-12-22
申请号：US17684747
申请日：2022-03-02
Applicant: C.R. BARD, INC.
Inventor： Andrzej J. CHANDUSZKO , Michael Randall , William Parmentier
Abstract: An endovascular apparatus takes the form of an expandable tubular body having a retriever, which may include a pair of interconnected hooks. The retriever may be formed from a single piece of material forming the tubular body, and in the case of a pair of hooks thus has a thickness corresponding to approximately twice the wall thickness of the tubular body. The innermost radial portion of the hooks may be offset from a central axis of a lumen formed by the tubular body, which facilitates free insertion of a balloon or the like for purposes of expanding the tubular body. Related methods of manufacturing an endovascular apparatus with a retriever are also described herein.
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公开(公告)号：US20210045769A1
公开(公告)日：2021-02-18
申请号：US17086570
申请日：2020-11-02
Applicant: C.R. Bard, Inc.
Inventor： Michael Randall , Chad Van Liere , Andrzej J. Chanduszko
IPC: A61B17/3207 , A61B17/22 , A61M25/10
Abstract: Dual-access site catheter systems with a blade or scoring functionality entering through a first access site and a balloon functionality for manipulating or driving the blade or scoring functionality through a different site. The blade or scoring functionality also sometimes provides needle or fluid delivery functionality to an atherosclerotic lesion.
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Patent Agency Ranking
公开(公告)号：US11285027B1
公开(公告)日：2022-03-29
申请号：US16733583
申请日：2020-01-03
Applicant: C.R. BARD, INC.
Inventor： Andrzej J. Chanduszko , Michael Randall , William Parmentier
Abstract: An endovascular apparatus takes the form of an expandable tubular body having a retriever, which may include a pair of interconnected hooks. The retriever may be formed from a single piece of material forming the tubular body, and in the case of a pair of hooks thus has a thickness corresponding to approximately twice the wall thickness of the tubular body. The innermost radial portion of the hooks may be offset from a central axis of a lumen formed by the tubular body, which facilitates free insertion of a balloon or the like for purposes of expanding the tubular body. Related methods of manufacturing an endovascular apparatus with a retriever are also described herein.
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公开(公告)号：US20210315606A1
公开(公告)日：2021-10-14
申请号：US17351464
申请日：2021-06-18
Applicant: C.R. BARD, INC.
Inventor： Andrzej Chanduszko , Michael Randall , Chad Van Liere
IPC: A61B17/3207 , A61M25/10
Abstract: A catheter for scoring or slicing a lesion. The catheter has a first receiver at a distal end of an expandable portion of the catheter shaft. A first carrier at least partially within the first receiver is moveable axially along the catheter shaft to deploy a first cutter along the expandable portion for cutting or scoring the lesion. In an alternative embodiment, the first carrier may be a wire having a loop, and thus forming a first length including the first cutter and a second length including a second cutter. Actuation of the wire thus causes simultaneous, reciprocal movement of the first and second cutters. Related methods are also disclosed.
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公开(公告)号：US20210052499A1
公开(公告)日：2021-02-25
申请号：US16913314
申请日：2020-06-26
Applicant: C.R. Bard, Inc.
Inventor： Elena Afonina , Hiep Do , Emily Goel , Oleg Guryev , Cyal Lecy , Majid Mehrpouyan , Michael Randall , Marybeth Sharkey , Jeffrey Wang
IPC: A61K9/16 , A61K31/4412 , A61K31/704 , A61K9/14 , A61K9/127 , A61K9/19
Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.
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公开(公告)号：US11950800B2
公开(公告)日：2024-04-09
申请号：US17351464
申请日：2021-06-18
Applicant: C.R. BARD, INC.
Inventor： Andrzej Chanduszko , Michael Randall , Chad Van Liere
IPC: A61B17/3207 , A61B17/22 , A61B90/00 , A61M25/10
CPC classification number: A61B17/320725 , A61M25/104 , A61B2017/22051 , A61B2090/3966 , A61M2025/1079 , A61M2025/109
Abstract: A catheter for scoring or slicing a lesion. The catheter has a first receiver at a distal end of an expandable portion of the catheter shaft. A first carrier at least partially within the first receiver is moveable axially along the catheter shaft to deploy a first cutter along the expandable portion for cutting or scoring the lesion. In an alternative embodiment, the first carrier may be a wire having a loop, and thus forming a first length including the first cutter and a second length including a second cutter. Actuation of the wire thus causes simultaneous, reciprocal movement of the first and second cutters. Related methods are also disclosed.
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10.发明公开公开(公告)号：US20230181456A1
公开(公告)日：2023-06-15
申请号：US18159408
申请日：2023-01-25
Applicant: C.R. Bard, Inc.
Inventor： Elena Afonina , Hiep Do , Emily Goel , Oleg Guryev , Cyal Lecy , Majid Mehrpouyan , Michael Randall , Marybeth Sharkey , Jeffrey Wang
CPC classification number: A61K9/0019 , A61K9/127
Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.
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