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    IMPLANTABLE MECHANICAL PRESSURE SENSOR AND METHOD OF MANUFACTURING THE SAME
    1.
    发明申请
    IMPLANTABLE MECHANICAL PRESSURE SENSOR AND METHOD OF MANUFACTURING THE SAME 审中-公开
    可植入机械压力传感器及其制造方法

    公开(公告)号：WO2005121735A3

    公开(公告)日：2006-11-23

    申请号：PCT/US2005020244

    申请日：2005-06-07

    Applicant: CALIFORNIA INST OF TECHN ,  TAI YU-CHONG ,  MENG ELLIS ,  CHEN PO-JUI ,  RODGER DAMIEN C ,  HUMAYUN MARK

    Inventor： TAI YU-CHONG ,  MENG ELLIS ,  CHEN PO-JUI ,  RODGER DAMIEN C ,  HUMAYUN MARK

    IPC: G01L7/00 ,  A61B3/16 ,  A61B5/00 ,  G01L7/04 ,  G01L7/08

    CPC classification number: A61B3/16 ,  A61B2562/02 ,  A61B2562/028 ,  G01L7/045

    Abstract: A biocompatible, mechanical, micromachined pressure sensor and methods of manufacturing such a pressure sensor are provided. The pressure sensor of the current invention comprises a high-aspect-ratio curved-tube structure fabricated through a one-layer parylene process. The pressure sensor of the current invention requires zero power consumption and indicates the pressure variation by changes of the in situ in-plane motion of the sensor, which can be gauged externally by a direct and convenient optical observation. In one embodiment, the pressure sensor of the current invention has been shown to work as an IOP sensor for eye implantation where the intraocular in-plane motion of the sensor can be recorded from outside of the eye, such that the intraocular pressure in glaucoma patients can be constantly monitored.

    Abstract translation: 提供生物相容的，机械的，微加工的压力传感器以及制造这种压力传感器的方法。 本发明的压力传感器包括通过一层帕利灵法制造的高纵横比弯曲管结构。 本发明的压力传感器需要零功率消耗，并且通过传感器的原位面内运动的变化来指示压力变化，其可以通过直接和方便的光学观察在外部测量。 在一个实施例中，本发明的压力传感器已被证明可用作眼睛植入的IOP传感器，其中可以从眼睛外部记录传感器的眼内平面内运动，使得青光眼患者的眼内压 可以不断监控。

    MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS
    2.
    发明申请
    MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS 审中-公开
    MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR用于生物医学应用和压力测量和传感器植入方法

    公开(公告)号：WO2008027996A3

    公开(公告)日：2008-10-09

    申请号：PCT/US2007077156

    申请日：2007-08-29

    Applicant: CALIFORNIA INST OF TECHN ,  TAI YU-CHONG ,  CHEN PO-JUI ,  RODGER DAMIEN C ,  HUMAYUN MARK S

    Inventor： TAI YU-CHONG ,  CHEN PO-JUI ,  RODGER DAMIEN C ,  HUMAYUN MARK S

    IPC: A61B3/16 ,  A61B13/00

    CPC classification number: A61B3/16 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/03 ,  G01L9/0072

    Abstract: A variable capacitor, a microfabricated implantable pressure sensor including a variable capacitor and an inductor, and related pressure measurement and implantation methods. The inductor may have a fixed or variable inductance. A variable capacitor and pressure sensors include a flexible member that is disposed on a substrate and defines a chamber. Capacitor elements extend indirectly from the flexible member. Sufficient fluidic pressure applied to an exterior surface of the flexible member causes the flexible member to move or deform, thus causing the capacitance and/or inductance to change. Resulting changes in resonant frequency or impedance can be detected to determine pressure, e.g., intraocular pressure.

    Abstract translation: 可变电容器，包括可变电容器和电感器的微制造植入式压力传感器以及相关的压力测量和植入方法。 电感器可能具有固定或可变的电感。 可变电容器和压力传感器包括设置在基板上并限定腔室的柔性构件。 电容器元件从柔性构件间接延伸。 施加到柔性构件的外表面的足够的流体压力导致柔性构件移动或变形，从而导致电容和/或电感改变。 可以检测共振频率或阻抗的结果变化以确定压力，例如眼内压。

    BATCH-FABRICATED FLEXIBLE INTRAOCULAR RETINAL PROSTHESIS SYSTEMS AND METHODS FOR MANUFACTURING THE SAME
    6.
    发明申请
    BATCH-FABRICATED FLEXIBLE INTRAOCULAR RETINAL PROSTHESIS SYSTEMS AND METHODS FOR MANUFACTURING THE SAME 审中-公开
    批量制作柔性肌内放射治疗系统及其制造方法

    公开(公告)号：WO2006116625A3

    公开(公告)日：2009-04-30

    申请号：PCT/US2006016070

    申请日：2006-04-28

    Applicant: CALIFORNIA INST OF TECHN ,  UNIV SOUTHERN CALIFORNIA ,  TAI YU-CHONG ,  RODGER DAMIEN C ,  LI WEN ,  HUMAYUN MARK ,  WEILAND JAMES D ,  AMERI HOSSEIN

    Inventor： TAI YU-CHONG ,  RODGER DAMIEN C ,  LI WEN ,  HUMAYUN MARK ,  WEILAND JAMES D ,  AMERI HOSSEIN

    IPC: A61F2/14 ,  A61F9/08 ,  A61N1/28 ,  A61N1/36

    CPC classification number: A61N1/0543 ,  A61F9/08 ,  A61N1/36046 ,  Y10T29/49002 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49156 ,  Y10T29/49224

    Abstract: Intraocular retinal prosthesis systems and methods for fabricating the same are provided. In one aspect, fabrication of all or multiple components of a prosthesis device or system are combined into a single monolithic fabrication process. Also, many such entire systems can be fabricated simultaneously in a single microfabrication processing run. A prosthesis device includes a cable region that connects an electrode array region with a power and data management region. The electrode array region includes one or more arrays of exposed electrodes, and the power and data management region includes various power and control elements. The power and data management elements, in one aspect, include an RF coil or coils and circuit arrangements and/or chips configured to provide drive signals to the electrodes via a cable and receive power and signals from the RF coil or coils. Each region includes elements fabricated on or in a single polymer layer during the same fabrication process.

    Abstract translation: 提供了眼内视网膜假体系统及其制造方法。 在一个方面，假体装置或系统的全部或多个部件的制造被组合成单个整体制造工艺。 此外，许多这样的整个系统可以在单个微细加工处理运行中同时制造。 假体装置包括将电极阵列区域与功率和数据管理区域连接的电缆区域。 电极阵列区域包括一个或多个暴露电极阵列，功率和数据管理区域包括各种功率和控制元件。 功率和数据管理元件在一个方面包括RF线圈或线圈以及经配置以通过电缆向电极提供驱动信号并且从RF线圈或线圈接收功率和信号的电路布置和/或芯片。 每个区域包括在同一制造过程中在单个聚合物层上或其中制造的元件。

    MICROFLUIDIC VALVE HAVING FREE-FLOATING MEMBER AND METHOD OF FABRICATION
    7.
    发明申请
    MICROFLUIDIC VALVE HAVING FREE-FLOATING MEMBER AND METHOD OF FABRICATION 审中-公开
    具有自由浮动部件的微流体阀及其制造方法

    公开(公告)号：WO2008022048A2

    公开(公告)日：2008-02-21

    申请号：PCT/US2007075746

    申请日：2007-08-10

    Applicant: CALIFORNIA INST OF TECHN ,  TAI YU-CHONG ,  CHEN PO-JUI ,  RODGER DAMIEN C ,  HUMAYUN MARK S

    Inventor： TAI YU-CHONG ,  CHEN PO-JUI ,  RODGER DAMIEN C ,  HUMAYUN MARK S

    IPC: B21D53/10 ,  F16K17/02

    CPC classification number: F16K99/0005 ,  F16K99/0015 ,  F16K99/0057 ,  Y10T29/49409 ,  Y10T137/0497 ,  Y10T137/7866 ,  Y10T137/7895 ,  Y10T137/7904 ,  Y10T137/7914

    Abstract: Micro check valves having a free-floating member for controlling flow of fluid in microfluidic and biomedical applications and methods of fabrication. A micro check valve includes a valve seat, a valve cap that contacts the valve seat and an untethered floating member that can move between the valve seat and the valve cap. Certain micro check valves have zero cracking pressure and no reverse leakage. Certain other valves may be configured to permit flow of fluid within a pressure range. The floating member can be solid or define an orifice, and the valve seat can have one or two levels. Valves can be configured to allow fluid to flow when the floating member is pushed by fluid against the valve cap or against the valve seat. The valve seat may be silicon or another material that is compatible with micromachining processes, and the valve cap and the floating member may be a polymer such as Parylene.

    Abstract translation: 微型止回阀具有自由浮动构件，用于控制微流体和生物医学应用中的流体流动和制造方法。 微型止回阀包括阀座，与阀座接触的阀帽以及可在阀座与阀帽之间移动的非系绳浮动构件。 某些微型止回阀具有零开启压力并且没有反向泄漏。 某些其他阀门可以构造成允许流体在压力范围内流动。 浮动构件可以是实心的或限定孔口，并且阀座可以具有一个或两个水平面。 当浮动构件被流体推动抵靠阀帽或抵靠阀座时，阀可被构造成允许流体流动。 阀座可以是硅或与微机械加工工艺兼容的另一种材料，并且阀帽和浮动构件可以是诸如聚对二甲苯的聚合物。

    METHOD FOR DECREASING CHEMICAL DIFFUSION IN PARYLENE AND TRAPPING AT PARYLENE-TO-PARYLENE INTERFACES
    8.
    发明申请
    METHOD FOR DECREASING CHEMICAL DIFFUSION IN PARYLENE AND TRAPPING AT PARYLENE-TO-PARYLENE INTERFACES 审中-公开
    减少化学扩散的方法，用于连接到亚胺连接物

    公开(公告)号：WO2006116326A3

    公开(公告)日：2007-11-01

    申请号：PCT/US2006015500

    申请日：2006-04-21

    Applicant: CALIFORNIA INST OF TECHN ,  TAI YU-CHONG ,  RODGER DAMIEN C ,  LI WEN ,  TOOKER ANGELA

    Inventor： TAI YU-CHONG ,  RODGER DAMIEN C ,  LI WEN ,  TOOKER ANGELA

    IPC: C23C16/00

    CPC classification number: B05D3/0254 ,  B05D1/60 ,  H01L21/312 ,  H01L21/76801 ,  H01L21/76826 ,  H01L21/76828

    Abstract: Systems and methods for improving the adherence of poorly-adherent parylene-to-parylene films or layers and/or altering the water and chemical permeability of the parylene layers. A device having two or more parylene layers is heated in a reduced pressure treatment chamber at a temperature above the deposition temperature of the parylene (e.g., from about room temperature to several hundreds of degrees Celsius) for an extended period of time (e.g., a few hours up to several days). The methods of the present invention have been shown to convert poorly-adherent and/or water-permeable films to optimally-adherent and/or relatively water-impermeable films.

    Abstract translation: 用于改善不良的对二甲苯对聚对二甲苯薄膜或层的粘附性和/或改变聚对二甲苯层的水和化学渗透性的系统和方法。 具有两个或更多个聚对二甲苯层的装置在减压处理室中在高于聚对二甲苯的沉积温度（例如从约室温至几百摄氏度）的温度下加热一段时间（例如， 几个小时到几天）。 已经显示出本发明的方法将不良粘附和/或水渗透膜转化成最佳粘附和/或相对不透水的膜。

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