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    INTEGRATED LC-ESI ON A CHIP
    2.
    发明申请
    INTEGRATED LC-ESI ON A CHIP 审中-公开
    集成LC-ESI芯片

    公开(公告)号：WO2006017217A2

    公开(公告)日：2006-02-16

    申请号：PCT/US2005/024518

    申请日：2005-07-11

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  CITY OF HOPE? ,  TAI, Yu-Chong ,  XIE, Jun ,  SHIH, Jason ,  LEE, Terry ,  MIAO, Yunan

    Inventor： TAI, Yu-Chong ,  XIE, Jun ,  SHIH, Jason ,  LEE, Terry ,  MIAO, Yunan

    IPC: C23F1/00

    CPC classification number: H01J49/04 ,  B01L3/5027 ,  G01N30/6095 ,  G01N30/7233 ,  G01N2030/326

    Abstract: A microfluidic system with on-chip pumping which can be used for liquid chromatography and also electrospray ionization mass spectrometry and which provides improved efficiency, better integration with sensors, improved portability, reduced power consumption, and reduced cost. The system can include (A) a main chip comprising: a substrate having a front face and a back face; a chromatography column on the front face of said substrate, wherein said column has an inlet and an outlet; an electrospray ionization (ESI) nozzle on the front face of said substrate, wherein said nozzle has an inlet and an outlet, and wherein the inlet of the nozzle is microfluidically coupled to the outlet of the column; one or more pump systems on the front face of said substrate comprising a pump chamber, one or more electrodes, and an outlet microfluidically coupled to the inlet of said column; and (B) a reservoir chip comprising a front surface and a back surface, wherein the reservoir chip has one or more cavities in the back surface which when disposed next to the front surface of the main chip extends the volume of the pump chamber of one of the pump system. Microfabrication can be used to prepare the chips, which can be assembled with a cover and inserted into a testing jig for electronic control and mass spectral analysis. Peptide separations are demonstrated which compete with present commercial systems.

    Abstract translation: 具有片上泵浦的微流体系统，其可用于液相色谱和电喷雾离子化质谱法，其提供更高的效率，更好地与传感器的集成，改进的便携性，降低的功率消耗和降低的成本。 该系统可以包括（A）主芯片，其包括：具有正面和背面的基板; 所述基板前表面上的色谱柱，其中所述色谱柱具有入口和出口; 在所述基板的正面上的电喷雾离子化（ESI）喷嘴，其中所述喷嘴具有入口和出口，并且其中所述喷嘴的入口微流体耦合到所述塔的出口; 所述衬底的前表面上的一个或多个泵系统包括泵室，一个或多个电极和微流体耦合到所述塔的入口的出口; 和（B）包括前表面和后表面的储存器芯片，其中所述储存器芯片在所述后表面中具有一个或多个空腔，当所述储存器芯片靠近所述主芯片的前表面设置时，所述泵室的体积将一个 的泵系统。 可以使用微加工来制备芯片，其可以用盖组装并插入用于电子控制和质谱分析的测试夹具中。 展示了与现有商业系统竞争的肽分离。

    INTEGRATED CAPACITIVE MICROFLUIDIC SENSORS METHOD AND APPARATUS
    3.
    发明申请
    INTEGRATED CAPACITIVE MICROFLUIDIC SENSORS METHOD AND APPARATUS 审中-公开
    集成电容式微流体传感器方法和装置

    公开(公告)号：WO2004085063A2

    公开(公告)日：2004-10-07

    申请号：PCT/US2004/008331

    申请日：2004-03-17

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  XIE, Jun ,  SHIH, Jason ,  TAI, Yu-Chong

    Inventor： XIE, Jun ,  SHIH, Jason ,  TAI, Yu-Chong

    IPC: B01L

    CPC classification number: G01N27/226 ,  B81B7/02 ,  B81B2201/0292 ,  B81B2201/058 ,  G01L9/0042 ,  G01L9/0072

    Abstract: A microfluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.

    Abstract translation: 用于电容感测的微流体装置和方法。 该装置包括流体通道，其包括在第一端处的入口和在第二端处的出口，耦合到流体通道的空腔区域以及耦合在流体通道和腔区域之间的基于聚合物的膜。 另外，该器件包括耦合到膜的第一电容器电极，耦合到空腔区域的第二电容器电极，并且至少通过腔区域与第一电容器电极物理分离;以及电源，耦合在第一电容器电极和 所述第二电容器电极至少在所述腔区域内引起电场。 基于聚合物的膜包括聚合物。

    INTEGRATED SURFACE-MACHINED MICRO FLOW CONTROLLER METHOD AND APPARATUS
    4.
    发明申请
    INTEGRATED SURFACE-MACHINED MICRO FLOW CONTROLLER METHOD AND APPARATUS 审中-公开
    综合表面加工微流控制器方法和装置

    公开(公告)号：WO2004065830A1

    公开(公告)日：2004-08-05

    申请号：PCT/US2004/001048

    申请日：2004-01-14

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  XIE, Jun ,  SHIH, Jason ,  TAI, Yu-Chong

    Inventor： XIE, Jun ,  SHIH, Jason ,  TAI, Yu-Chong

    IPC: F16K31/02

    CPC classification number: F16K99/0001 ,  F16K99/0015 ,  F16K99/0044 ,  F16K99/0051 ,  F16K99/0061 ,  F16K2099/0074 ,  F16K2099/008 ,  G01F1/6845 ,  G01F15/005 ,  G05D7/0694 ,  Y10T29/49412 ,  Y10T137/0391

    Abstract: A surface-micromachined mass flow controller (MFC) comprises an electrostatically actuated microvalve integrated with a thermal flow sensor. The microvalve comprises a normally-open diaphragm defining an aperture allowing fluid communication between first and second flow channels. The diaphragm includes a second electrode actuable toward a valve seat including a first electrode. Fabricated utilizing a multilayer Parylene process, the active microvalve and the flow sensor are integrated onto a single chip to perform closed-loop flow control. For flow control, both Pulse Width Modulation (PWM) and actuation voltage adjustment are demonstrated.

    Abstract translation: 表面微加工质量流量控制器（MFC）包括与热流量传感器集成的静电致动微型阀。 微型阀包括限定允许第一和第二流动通道之间流体连通的孔的常开隔膜。 隔膜包括能够朝向包括第一电极的阀座致动的第二电极。 采用多层Parylene工艺制造，将活性微型阀和流量传感器集成到单个芯片上，以执行闭环流量控制。 对于流量控制，展示了脉宽调制（PWM）和启动电压调节。

    INTEGRATED CAPACITIVE MICROFLUIDIC SENSORS METHOD AND APPARATUS
    7.
    发明公开
    INTEGRATED CAPACITIVE MICROFLUIDIC SENSORS METHOD AND APPARATUS 有权
    集成电容微流体传感器，方法和设备

    公开(公告)号：EP1603672A2

    公开(公告)日：2005-12-14

    申请号：EP04757825.7

    申请日：2004-03-17

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： XIE, Jun ,  SHIH, Jason ,  TAI, Yu-Chong

    IPC: B01L1/00

    CPC classification number: G01N27/226 ,  B81B7/02 ,  B81B2201/0292 ,  B81B2201/058 ,  G01L9/0042 ,  G01L9/0072

    Abstract: A microfluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.

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