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公开(公告)号：US11439688B2
公开(公告)日：2022-09-13
申请号：US16590045
申请日：2019-10-01
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Anirban Sen Gupta , Christa Pawloski
IPC: A61K38/39 , A61K9/127 , A61K9/48 , A61K47/69 , C07K14/745 , A61K38/00 , A61K38/17 , A61K47/62 , A61K9/00 , A61K9/19 , A61K38/18 , C07K14/195 , C07K14/705 , C07K14/78 , B82Y5/00
Abstract: A synthetic platelet including a biocompatible flexible nanoparticle, the nanoparticle having an outer surface and a plurality of site targeted peptides conjugated to the surface, the synthetic platelet also including a therapeutic agent, wherein the therapeutic agent is encapsulated by the nanoparticle, wherein the synthetic platelet adheres to the site targeted and promotes delivery of the therapeutic agent onto sites of the synthetic platelet adhesion, and wherein the therapeutic agent is released at the site targeted via a site-relevant enzyme.
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公开(公告)号：US20250134969A1
公开(公告)日：2025-05-01
申请号：US18835102
申请日：2023-02-02
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Anirban Sen Gupta , Aditya Girish
Abstract: A biosynthetic hemostat includes a plurality of biocompatible flexible nanoparticles wherein each nanoparticle includes a shell that defines an outer surface of the nanoparticle and a core, which is loaded with thrombin, and a plurality of von Willebrand factor-binding peptides (VBPs) and collagen-binding peptides (CBPs) that are linked to the shell and extend from the outer surface.
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公开(公告)号：US20250041390A1
公开(公告)日：2025-02-06
申请号：US18626999
申请日：2024-04-04
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Anirban Sen Gupta
Abstract: A composition includes a plurality of clot-targeted thrombin cleavable nanoparticles (CTNPs), each CTNP including a thrombin cleavable shell that defines an outer surface of the CTNP, a core, which is loaded with plasmin, and a plurality of platelet binding peptides (PBPs) and fibrin binding peptides (FBPs) that are linked to the shell and extend from the outer surface, wherein the CTNP is configured to adhere to clots, activated platelets, and/or fibrin upon systemic administration to a subject, shield the loaded plasmin in circulation from neutralization, and release the loaded plasmin at the clot site by thrombin triggered degradation of the CTNP.
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公开(公告)号：US11648323B2
公开(公告)日：2023-05-16
申请号：US16933434
申请日：2020-07-20
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Anirban Sen Gupta , Madhumitha Ravikumar , Christa Modery
CPC classification number: A61K47/6911 , A61K38/49 , A61K47/62 , A61K49/0032 , A61K49/0041 , A61K49/0043 , A61K49/0084 , C12Y304/21068
Abstract: A composition for use in diagnostic and therapeutic applications includes a heteromultivalent nanoparticle or microparticle having an outer surface and a plurality of targeting moieties conjugated to the surface of the nanoparticle or microparticle, the targeting moieties includes a first activated platelet targeting moiety and a second activated platelet targeting moiety.
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公开(公告)号：US10716865B2
公开(公告)日：2020-07-21
申请号：US15832526
申请日：2017-12-05
Applicant: Case Western Reserve University
Inventor： Anirban Sen Gupta , Madhumitha Ravikumar , Christa Modery
Abstract: A composition for use in diagnostic and therapeutic applications includes a heteromultivalent nanoparticle or microparticle having an outer surface and a plurality of targeting moieties conjugated to the surface of the nanoparticle or microparticle, the targeting moieties includes a first activated platelet targeting moiety and a second activated platelet targeting moiety.
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Patent Agency Ranking
公开(公告)号：US20190054151A1
公开(公告)日：2019-02-21
申请号：US16017174
申请日：2018-06-25
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Anirban Sen Gupta , Christa Pawloski
CPC classification number: A61K38/39 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K9/19 , A61K9/4825 , A61K38/00 , A61K38/177 , A61K38/1774 , A61K38/185 , A61K47/62 , A61K47/6911 , B82Y5/00 , C07K14/195 , C07K14/70596 , C07K14/745 , C07K14/78
Abstract: A synthetic platelet including a biocompatible flexible nanoparticle, the nanoparticle having an outer surface and a plurality of site targeted peptides conjugated to the surface, the synthetic platelet also including a therapeutic agent, wherein the therapeutic agent is encapsulated by the nanoparticle, wherein the synthetic platelet adheres to the site targeted and promotes delivery of the therapeutic agent onto sites of the synthetic platelet adhesion, and wherein the therapeutic agent is released at the site targeted via a site-relevant enzyme.
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公开(公告)号：US09107963B2
公开(公告)日：2015-08-18
申请号：US13863005
申请日：2013-04-15
Applicant: Case Western Reserve University
Inventor： Anirban Sen Gupta , Madhumitha Ravikumar , Christa Modery
IPC: A61K38/00 , A61K38/36 , C07K14/745 , A61K9/127 , A61K9/16 , A61K9/50 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K47/48 , A61K38/49 , A61K49/00
CPC classification number: A61K47/48815 , A61K38/49 , A61K47/62 , A61K47/6911 , A61K49/0032 , A61K49/0041 , A61K49/0043 , A61K49/0084
Abstract: A composition for use in diagnostic and therapeutic applications includes a heteromultivalent nanoparticle having an outer surface and a plurality of targeting moieties conjugated to the surface of the nanoparticle, the targeting moieties includes a first activated platelet targeting moiety and a second activated platelet targeting moiety.
Abstract translation: 用于诊断和治疗应用的组合物包括具有外表面和与纳米颗粒表面缀合的多个靶向部分的异源纳米颗粒，靶向部分包括第一活化的血小板靶向部分和第二活化的血小板靶向部分。
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公开(公告)号：US20250153167A1
公开(公告)日：2025-05-15
申请号：US18942926
申请日：2024-11-11
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Pedram Mohseni , Anirban Sen Gupta , Dante Disharoon , Changyong Cao , Michael Suster , Emily Song
IPC: B01L3/00
Abstract: As one example, methods and systems are provided for aerosol jet printing one or more bioactive agents on a substrate to functionalize the substrate. This disclosure also relates to the resulting functionalized substrates as well as to sensing devices and systems that include such functionalized substrates.
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公开(公告)号：US12161698B2
公开(公告)日：2024-12-10
申请号：US17943955
申请日：2022-09-13
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Anirban Sen Gupta , Christa Pawloski
IPC: A61K38/39 , A61K9/00 , A61K9/127 , A61K9/19 , A61K9/48 , A61K38/00 , A61K38/17 , A61K38/18 , A61K47/62 , A61K47/69 , B82Y5/00 , C07K14/195 , C07K14/705 , C07K14/745 , C07K14/78
Abstract: A synthetic platelet including a biocompatible flexible nanoparticle, the nanoparticle having an outer surface and a plurality of site targeted peptides conjugated to the surface, the synthetic platelet also including a therapeutic agent, wherein the therapeutic agent is encapsulated by the nanoparticle, wherein the synthetic platelet adheres to the site targeted and promotes delivery of the therapeutic agent onto sites of the synthetic platelet adhesion, and wherein the therapeutic agent is released at the site targeted via a site-relevant enzyme.
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公开(公告)号：US20240024430A1
公开(公告)日：2024-01-25
申请号：US17943955
申请日：2022-09-13
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Anirban Sen Gupta , Christa Pawloski
IPC: A61K38/39 , A61K9/127 , A61K9/48 , A61K47/69 , C07K14/745 , A61K38/00 , A61K38/17 , A61K47/62 , A61K9/00 , A61K9/19 , A61K38/18 , C07K14/195 , C07K14/705 , C07K14/78
CPC classification number: A61K38/39 , A61K9/127 , A61K9/4825 , A61K9/1271 , A61K47/6911 , C07K14/745 , A61K38/00 , A61K38/177 , A61K38/1774 , A61K47/62 , A61K9/0019 , A61K9/19 , A61K38/185 , C07K14/195 , C07K14/70596 , C07K14/78 , B82Y5/00
Abstract: A synthetic platelet including a biocompatible flexible nanoparticle, the nanoparticle having an outer surface and a plurality of site targeted peptides conjugated to the surface, the synthetic platelet also including a therapeutic agent, wherein the therapeutic agent is encapsulated by the nanoparticle, wherein the synthetic platelet adheres to the site targeted and promotes delivery of the therapeutic agent onto sites of the synthetic platelet adhesion, and wherein the therapeutic agent is released at the site targeted via a site-relevant enzyme.
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