公开(公告)号：CA2502152A1

公开(公告)日：2004-04-29

申请号：CA2502152

申请日：2003-10-15

Applicant: CELLTECH R&D LTD

Inventor： HUMPHREYS DAVID PAUL ,  SPITALI MARIANGELA ,  ROBINSON MARTYN KIM ,  CHAPMAN ANDREW PAUL

IPC: C07K14/245 ,  C12N1/20 ,  C12N1/21 ,  C12N15/31 ,  C12N15/70 ,  C12N15/13

Abstract: The present invention provides an Ecoli host cell expressing a recombinant antibody characterized in that the Ecolihost cell has been genetically modified in order to change at least one physical property of one or more Ecoli proteins which in the wild type co~purify with said recombinant antibo dy.