公开(公告)号：US20210104028A1

公开(公告)日：2021-04-08

申请号：US17061686

申请日：2020-10-02

Applicant: CHEMIMAGE CORPORATION

Inventor： Heather GOMER ,  Patrick TREADO ,  Jihang WANG

IPC: G06T5/50 ,  H04N5/225 ,  H04N5/265 ,  G06T5/00 ,  H04N5/247 ,  H04N5/232 ,  G01N33/483

Abstract: Methods, systems, and computer program products of fusing Molecular Chemical Imaging (MCI) and Red Green Blue (RGB) images are disclosed herein. A sample is illuminated with illuminating photons which interact with the sample and are used to form MCI and RGB images. The MCI and RGB images are fused by way of mathematical operations to generate a RGB image with a detection overlay.

公开(公告)号：US20180348136A1

公开(公告)日：2018-12-06

申请号：US15776649

申请日：2016-11-16

Applicant: ChemImage Corporation

Inventor： Patrick TREADO ,  Shona STEWART ,  Aaron SMITH ,  Heather GOMER

IPC: G01N21/65 ,  G01N21/17 ,  G01J3/44 ,  G01N33/53 ,  G16H50/20

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0833

Abstract: This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.

公开(公告)号：US20200245930A1

公开(公告)日：2020-08-06

申请号：US16781610

申请日：2020-02-04

Applicant: CHEMIMAGE CORPORATION

Inventor： Jeffrey K. COHEN ,  J. Christopher POST ,  Shona STEWART ,  Patrick J. TREADO ,  Heather GOMER ,  Aaron SMITH

IPC: A61B5/00 ,  G01J3/28 ,  G01J3/42 ,  G01J3/02

Abstract: Systems and methods of detecting and monitoring edema in a subject are described. The systems and methods include light sources, image detectors, filters, and processors that determine whether a subject has edema and the degree of severity. In some embodiments, the processor fuses data from more than one imaging modality.

公开(公告)号：US20200054280A1

公开(公告)日：2020-02-20

申请号：US16544499

申请日：2019-08-19

Applicant: CHEMIMAGE CORPORATION

Inventor： Jeffrey COHEN ,  Patrick TREADO ,  Shona STEWART ,  Heather GOMER ,  Arash SAMIEI ,  Alyssa ZRIMSEK ,  Jihang WANG

IPC: A61B5/00 ,  A61B1/06 ,  A61B1/00

Abstract: Systems and methods for the detection of calculi in the biliary system are disclosed. The systems include an illumination source, one or more filters that filter a first set of illumination photons and a second set of illumination photons, as well as associated processors and detectors. The system is also designed to generates image data sets and generated information related to the location of the calculi.

公开(公告)号：US20230035060A1

公开(公告)日：2023-02-02

申请号：US17723186

申请日：2022-04-18

Applicant: CHEMIMAGE CORPORATION

Inventor： Shawna TAZIK ,  Alyssa ZRIMSEK ,  Heather GOMER ,  Jihang WANG ,  Patrick J. TREADO

IPC: G01J3/28 ,  G01J3/10

Abstract: Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.

公开(公告)号：US20220142457A1

公开(公告)日：2022-05-12

申请号：US17582764

申请日：2022-01-24

Applicant: CHEMIMAGE CORPORATION

Inventor： Jeffrey COHEN ,  Patrick TREADO ,  Shona STEWART ,  Heather GOMER ,  Arash SAMIEI ,  Alyssa ZRIMSEK ,  Jihang WANG

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/06

Abstract: Systems and methods for the detection of calculi in the biliary system are disclosed. The systems include an illumination source, one or more filters that filter a first set of illumination photons and a second set of illumination photons, as well as associated processors and detectors. The system is also designed to generates image data sets and generated information related to the location of the calculi.

公开(公告)号：US20210356391A1

公开(公告)日：2021-11-18

申请号：US17321206

申请日：2021-05-14

Applicant: CHEMIMAGE CORPORATION

Inventor： Shona STEWART ,  Heather GOMER ,  Arash SAMIEI ,  Marlena DARR

IPC: G01N21/31 ,  G01N21/21 ,  G01N21/25 ,  G01N21/33 ,  G01N21/3581 ,  G01N21/359 ,  G01N33/483

Abstract: Systems and methods designed to determine tumor histological subtypes in order to guide a surgical procedure. The systems and methods illuminate biological tissue in order to generate a plurality of interacted photons, collect the interacted photons, detect the plurality of a interacted photons to generate at least one hyperspectral image, and analyze a hyperspectral image by extracting a spectrum from a location in the hyperspectral image. The location should correspond to an area that is of interest in the biological tissue.

公开(公告)号：US20210190586A1

公开(公告)日：2021-06-24

申请号：US17127464

申请日：2020-12-18

Applicant: CHEMIMAGE CORPORATION

Inventor： Alyssa ZRIMSEK ,  Heather GOMER ,  Shawna TAZIK

IPC: G01J3/02 ,  G01J3/447 ,  G01J3/457

Abstract: Techniques, devices and methods for discriminating a target from a background material without optimizing directly on the target are provided. The devices and methods can generate pass bands of single or multiple wavelengths of variable shape and intensity, and can also select and control the shape of the pass band profiles to improve the detection of targets of interest.

公开(公告)号：US20210181101A1

公开(公告)日：2021-06-17

申请号：US17121247

申请日：2020-12-14

Applicant: CHEMIMAGE CORPORATION

Inventor： Alyssa ZRIMSEK ,  Matthew NELSON ,  Lei SHI ,  Heather GOMER ,  Shawna TAZIK

IPC: G01N21/3563 ,  H04N5/225 ,  A61B90/30 ,  A61B90/00

Abstract: Systems for and methods for detecting samples and other compounds of interest are disclosed herein. The system can include an illumination source that is configured to emit light in a variety of different wavelength bands, an optical filter, a camera chip, and an optical path configured to direct the light emitted by the first illumination source at a target and direct the light reflected from the target to the at least one camera chip. The illumination source and the optical filter are transitionable between a first tuning state corresponding to a target tissue and a second tuning state corresponding to a background tissue. The system can be configured to record images at the different tuning states and generate a score image corresponding to the target tissue based on the recorded images.

公开(公告)号：US20210172798A1

公开(公告)日：2021-06-10

申请号：US17112393

申请日：2020-12-04

Applicant: CHEMIMAGE CORPORATION

Inventor： Shawna TAZIK ,  Alyssa ZRIMSEK ,  Heather GOMER ,  Jihang WANG ,  Patrick J. TREADO

IPC: G01J3/28 ,  G01J3/10

Abstract: Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.