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    SYSTEMS AND METHODS FOR DETECTING ORAL CANCER USING MOLECULAR CHEMICAL IMAGING
    1.
    发明申请
    SYSTEMS AND METHODS FOR DETECTING ORAL CANCER USING MOLECULAR CHEMICAL IMAGING 有权

    公开(公告)号：US20210353225A1

    公开(公告)日：2021-11-18

    申请号：US17323462

    申请日：2021-05-18

    Applicant: CHEMIMAGE CORPORATION

    Inventor： Shona STEWART ,  Aaron SMITH ,  Patrick J. TREADO

    IPC: A61B5/00 ,  A61B1/07 ,  A61B1/06 ,  A61B1/05 ,  A61B1/04 ,  A61B1/24

    Abstract: Methods and systems of identifying oral cancer in vivo are disclosed. An oral cavity of a patient is illuminated with a plurality of illuminating photons. A plurality of interacted photos are received from the oral cavity. The interacted photons may have been absorbed, reflected, scattered or emitted by the oral cavity. The interacted photons are filtered into first and second polarized multi-passband wavelengths using first and second tunable conformal filters, respectively. A detector captures the first and second polarized multi-passband wavelengths. A processor automatically discriminates between cancerous tissue and non-cancerous tissue in an image resolved from the first and second polarized multi-passband wavelengths.

    RAMAN-BASED IMMUNOASSAY SYSTEMS AND METHODS
    3.
    发明申请
    RAMAN-BASED IMMUNOASSAY SYSTEMS AND METHODS 审中-公开

    公开(公告)号：US20180348136A1

    公开(公告)日：2018-12-06

    申请号：US15776649

    申请日：2016-11-16

    Applicant: ChemImage Corporation

    Inventor： Patrick TREADO ,  Shona STEWART ,  Aaron SMITH ,  Heather GOMER

    IPC: G01N21/65 ,  G01N21/17 ,  G01J3/44 ,  G01N33/53 ,  G16H50/20

    CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0833

    Abstract: This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.

    SYSTEMS AND METHODS OF COMBINING IMAGING MODALITIES FOR IMPROVED TISSUE DETECTION
    4.
    发明申请
    SYSTEMS AND METHODS OF COMBINING IMAGING MODALITIES FOR IMPROVED TISSUE DETECTION 有权

    公开(公告)号：US20210192295A1

    公开(公告)日：2021-06-24

    申请号：US17126710

    申请日：2020-12-18

    Applicant: CHEMIMAGE CORPORATION

    Inventor： Shona STEWART ,  Patrick J. TREADO

    IPC: G06K9/62 ,  H04N5/225 ,  G06K9/20

    Abstract: Systems of methods of combining imaging modalities for improved target detection within a sample are disclosed herein. The system can be configured to receive two or more images captured using different imaging modalities, create a score image from one of the captured images, fuse the second image and the score image together, identify the target within the score image or the fused image, register the received images together, and overlay the detected target on the first image. The first image can include an image captured using molecular chemical imaging and the second image can include a RGB image, for example.

    MOLECULAR CHEMICAL IMAGING ENDOSCOPIC IMAGING SYSTEMS
    5.
    发明申请
    MOLECULAR CHEMICAL IMAGING ENDOSCOPIC IMAGING SYSTEMS 有权

    公开(公告)号：US20210068639A1

    公开(公告)日：2021-03-11

    申请号：US17027340

    申请日：2020-09-21

    Applicant: ChemImage Corporation

    Inventor： Patrick TREADO ,  Matthew NELSON ,  Shona STEWART

    IPC: A61B1/04 ,  A61B1/06 ,  A61B1/307 ,  A61B1/07 ,  A61B1/00

    Abstract: The instant disclosure provides for medical imaging systems that may be used in conjunction with an intraoperative medical device, such as an endoscope. Generally, the disclosed medical imaging systems include an illumination source configured to generate illuminating photons for illuminating a biological sample. An optical signal modulator is configured to separate one or more of the illuminating photons and photons that have interacted with the biological sample into a first optical signal having first multi-passband wavelengths and a second optical signal having second multi-passband wavelengths. At least one detector is configured to detect one or more of the first optical signal and the second optical signal and generate at least one image data set. A processor is configured to analyze the at least one image data set. In some embodiments, the processor is configured to differentiate between structures of the biological sample, such as between an ureter and surrounding tissue.

    METHODS FOR DETERMINING BLOOD OXYGENATION AND TISSUE PERFUSION LEVELS AND DEVICES THEREOF
    8.
    发明申请
    METHODS FOR DETERMINING BLOOD OXYGENATION AND TISSUE PERFUSION LEVELS AND DEVICES THEREOF 有权

    公开(公告)号：US20210393149A1

    公开(公告)日：2021-12-23

    申请号：US17355933

    申请日：2021-06-23

    Applicant: CHEMIMAGE CORPORATION

    Inventor： Patrick J. TREADO ,  Heather E. GOMER ,  Shona STEWART ,  Aaron G. SMITH

    IPC: A61B5/026

    Abstract: Methods for improved tissue perfusion monitoring are disclosed. A method includes collecting hyperspectral image data from an image sensor positioned to collect interacted photons from a tissue region resulting from illumination of the tissue sample at a plurality of wavelengths in the visible, near infrared, or shortwave infrared regions. Hypercubes are generated based on the collected hyperspectral image data. The hypercubes are analyzed to identify one or more of the plurality of wavelengths resulting in contrast in the hyperspectral images. One or more regions in the tissue region with altered perfusion states are identified based on the contrast in the hyperspectral images. A tissue perfusion monitoring computing device and non-transitory medium are also disclosed.

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