公开(公告)号：SK141696A3

公开(公告)日：1997-06-04

申请号：SK141696

申请日：1995-04-27

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  BARNARD STEVEN ,  BERGER JOSEPH ,  BLOM NILS ,  ROUILLY MARIZEL

IPC: C07D311/78 ,  C07D311/90 ,  C08F220/54 ,  C08F291/00 ,  G01N31/00 ,  C09D4/06 ,  G01N21/78 ,  G01N31/22 ,  C08F220/58 ,  C07D311/80

Abstract: A copolymer comprising at least one recurring structural unit of formula VII optionally at least one recurring structural unit of formula VIII and recurring structural units of formula IX wherein Rk is hydrogen or methyl, Rm is hydrogen or C1-C12alkyl, phenyl or benzyl, Rn ad Ro are each independently of the other C1-C12alkyl, phenyl or benzyl or Rn and Ro together are tetramethylene, pentamethylene, -(CH2)2-O-(CH2)2- or -(CH2)2-N(C1-C6alkyl)-(CH2)2-, and F is the radical of a fluorophore bonded directly or via a bridge group to the N atom, with the proviso that at least two different recurring structural units of formula VII or at least one structural unit of formula VII and at least one structural unit of formula VIII are present. The copolymers can be used for optical pH sensors.

公开(公告)号：FI964333A0

公开(公告)日：1996-10-28

申请号：FI964333

申请日：1996-10-28

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  BARNARD STEVEN ,  BERGER JOSEPH ,  BLOM NILS ,  ROUILLY MARIZEL

IPC: G01N31/00 ,  C07D311/78 ,  C07D311/90 ,  C08F220/54 ,  C08F291/00 ,  C09D4/06 ,  G01N21/78 ,  G01N31/22 ,  G01N

Abstract: A copolymer comprising at least one recurring structural unit of formula VII optionally at least one recurring structural unit of formula VIII and recurring structural units of formula IX wherein Rk is hydrogen or methyl, Rm is hydrogen or C1-C12alkyl, phenyl or benzyl, Rn ad Ro are each independently of the other C1-C12alkyl, phenyl or benzyl or Rn and Ro together are tetramethylene, pentamethylene, -(CH2)2-O-(CH2)2- or -(CH2)2-N(C1-C6alkyl)-(CH2)2-, and F is the radical of a fluorophore bonded directly or via a bridge group to the N atom, with the proviso that at least two different recurring structural units of formula VII or at least one structural unit of formula VII and at least one structural unit of formula VIII are present. The copolymers can be used for optical pH sensors.

公开(公告)号：CA2119840A1

公开(公告)日：1994-09-27

申请号：CA2119840

申请日：1994-03-24

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  BARNARD STEVEN

IPC: A61K35/74 ,  C07D219/08 ,  C07D311/80 ,  C07D311/82 ,  C09D201/00 ,  G01N21/78 ,  G01N31/22 ,  G01N21/79 ,  G01N33/52 ,  G01N33/84

Abstract: Optical sensor for the determination of cations Compounds of the formulae I and II (I), (II), in which R1 and R3, and R4 and R6 are C1-C30alkyl or C1-C30alkyl-CO-, and R2 and R5 are H or C1-C30alkyl, with the proviso that the total number of carbon atoms in the alkyl groups is at least 12, and salts thereof with inorganic or organic acids are fluorophores of high basicity which can be used in membranes for the optical determination of cations in aqueous media, in particular potassium ions, through the measurement, in particular, of the concentration-dependent reduction in fluorescence.

公开(公告)号：BR9001484A

公开(公告)日：1991-04-16

申请号：BR9001484

申请日：1990-03-30

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  RINDLISBACHER ALFRED ,  STREIBERT HANS-PETER ,  BAENNINGER RUDOLF

IPC: A01N25/22 ,  A01N47/30 ,  A01N47/32 ,  A01N47/28

Abstract: The simultaneous use of photosensitisers can improve and prolong the insecticidal and acaricidal action of N-phenyl-thioureas and can also cause this action after application within a shorter period of time.

公开(公告)号：AU5244190A

公开(公告)日：1990-10-04

申请号：AU5244190

申请日：1990-03-30

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  RINDLISBACHER ALFRED ,  STREIBERT HANS-PETER ,  BANNINGER RUDOLF

IPC: A01N25/22 ,  A01N47/30 ,  A01N47/32

Abstract: The simultaneous use of photosensitisers can improve and prolong the insecticidal and acaricidal action of N-phenyl-thioureas and can also cause this action after application within a shorter period of time.

公开(公告)号：HU192231B

公开(公告)日：1987-05-28

申请号：HU241885

申请日：1985-06-19

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  STANEK JAROSLAV ,  BELLUS DANIEL

IPC: A61K31/435 ,  A61P35/00 ,  A61P43/00 ,  C07D211/88 ,  C07D221/22 ,  C07D311/00 ,  C12N9/99 ,  C07D471/08

Abstract: 1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula (I) in which R1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R2 represents hydrogen, lower alkyl, sulpho or acyl, R3 represents hydrogen or lower alkyl and R4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by -N(R2)(R3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

公开(公告)号：DD245871A5

公开(公告)日：1987-05-20

申请号：DD29028685

申请日：1985-06-18

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  STANEK JAROSLAV ,  BELLUS DANIEL

IPC: A61K31/435 ,  A61P35/00 ,  A61P43/00 ,  C07D211/88 ,  C07D221/22 ,  C07D311/00 ,  C12N9/99 ,  C07D223/08

Abstract: 1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula (I) in which R1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R2 represents hydrogen, lower alkyl, sulpho or acyl, R3 represents hydrogen or lower alkyl and R4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by -N(R2)(R3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

公开(公告)号：HUT38346A

公开(公告)日：1986-05-28

申请号：HU241885

申请日：1985-06-19

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  STANEK JAROSLAV ,  BELLUS DANIEL

IPC: A61K31/435 ,  A61P35/00 ,  A61P43/00 ,  C07D211/88 ,  C07D221/22 ,  C07D311/00 ,  C12N9/99 ,  C07D471/08

Abstract: 1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula (I) in which R1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R2 represents hydrogen, lower alkyl, sulpho or acyl, R3 represents hydrogen or lower alkyl and R4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by -N(R2)(R3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

公开(公告)号：FI852429A0

公开(公告)日：1985-06-19

申请号：FI852429

申请日：1985-06-19

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  STANEK JAROSLAV ,  BELLUS DANIEL

IPC: A61K31/435 ,  A61P35/00 ,  A61P43/00 ,  C07D211/88 ,  C07D221/22 ,  C07D311/00 ,  C12N9/99 ,  C07D

Abstract: 1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula (I) in which R1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R2 represents hydrogen, lower alkyl, sulpho or acyl, R3 represents hydrogen or lower alkyl and R4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by -N(R2)(R3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

公开(公告)号：HU9603017D0

公开(公告)日：1997-01-28

申请号：HU9603017

申请日：1995-04-27

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  BARNARD STEVEN ,  BERGER JOSEPH ,  BLOM NILS ,  ROUILLY MARIZEL

IPC: G01N31/00 ,  C07D311/78 ,  C07D311/90 ,  C08F220/54 ,  C08F291/00 ,  C09D4/06 ,  G01N21/78 ,  G01N31/22

Abstract: A copolymer comprising at least one recurring structural unit of formula VII optionally at least one recurring structural unit of formula VIII and recurring structural units of formula IX wherein Rk is hydrogen or methyl, Rm is hydrogen or C1-C12alkyl, phenyl or benzyl, Rn ad Ro are each independently of the other C1-C12alkyl, phenyl or benzyl or Rn and Ro together are tetramethylene, pentamethylene, -(CH2)2-O-(CH2)2- or -(CH2)2-N(C1-C6alkyl)-(CH2)2-, and F is the radical of a fluorophore bonded directly or via a bridge group to the N atom, with the proviso that at least two different recurring structural units of formula VII or at least one structural unit of formula VII and at least one structural unit of formula VIII are present. The copolymers can be used for optical pH sensors.