公开(公告)号：NO166444B

公开(公告)日：1991-04-15

申请号：NO852478

申请日：1985-06-19

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  STANEK JAROSLAV ,  BELLUS DANIEL

IPC: A61K31/435 ,  A61P35/00 ,  A61P43/00 ,  C07D211/88 ,  C07D221/22 ,  C07D311/00 ,  C12N9/99

Abstract: 1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula (I) in which R1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R2 represents hydrogen, lower alkyl, sulpho or acyl, R3 represents hydrogen or lower alkyl and R4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by -N(R2)(R3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

公开(公告)号：PH21957A

公开(公告)日：1988-04-15

申请号：PH32419

申请日：1985-06-18

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  STANEK JAROSLAV ,  BELLUS DANIEL

IPC: A61K31/435 ,  A61P35/00 ,  A61P43/00 ,  C07D211/88 ,  C07D221/22 ,  C07D311/00 ,  C12N9/99 ,  A61K31/46 ,  C07D221/16

Abstract: 1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula (I) in which R1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R2 represents hydrogen, lower alkyl, sulpho or acyl, R3 represents hydrogen or lower alkyl and R4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by -N(R2)(R3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

公开(公告)号：HU194180B

公开(公告)日：1988-01-28

申请号：HU419386

申请日：1985-06-19

Applicant: CIBA GEIGY AG

Inventor： ADLER ALEX ,  STANEK JAROSLAV ,  BELLUS DANIEL

IPC: A61K31/435 ,  A61P35/00 ,  A61P43/00 ,  C07D211/88 ,  C07D221/22 ,  C07D311/00 ,  C12N9/99

Abstract: 1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula (I) in which R1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R2 represents hydrogen, lower alkyl, sulpho or acyl, R3 represents hydrogen or lower alkyl and R4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by -N(R2)(R3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

公开(公告)号：ZA8504613B

公开(公告)日：1986-02-26

申请号：ZA8504613

申请日：1985-06-19

Applicant: CIBA GEIGY AG

Inventor： ALDER ALEX ,  STANEK JAROSLAV ,  BELLUS DANIEL

IPC: A61K31/435 ,  A61P35/00 ,  A61P43/00 ,  C07D211/88 ,  C07D221/22 ,  C07D311/00 ,  C12N9/99 ,  C07D ,  A61K

CPC classification number: C07D221/22 ,  C07D311/00

公开(公告)号：MX5208E

公开(公告)日：1983-04-25

申请号：MX755478

申请日：1978-11-23

Applicant: CIBA GEIGY AG

Inventor： MARTIN PIERRE ,  BELLUS DANIEL

IPC: C07C57/76 ,  C07C45/00 ,  C07C45/89 ,  C07C49/687 ,  C07C49/693 ,  C07C49/88 ,  C07C51/00 ,  C07C51/60 ,  C07C51/62 ,  C07C61/40 ,  C07C67/00 ,  C07C49/45

公开(公告)号：GB2103204A

公开(公告)日：1983-02-16

申请号：GB8216117

申请日：1978-10-23

Applicant: CIBA GEIGY AG

Inventor： MARTIN PIERRE ,  GREUTER HANS ,  STEINER EGINHARD ,  BELLUS DANIEL

IPC: C07C45/45 ,  C07C45/67 ,  C07C49/457 ,  C07C49/477 ,  C07C51/295 ,  C07C51/60 ,  C07C51/62 ,  C07C49/385

Abstract: The invention provides 2- (2',2',2'-tribromoethyl)-4- chlorocyclobutan-1-ones of the formula I in which one of the radicals R1 and R2 is methyl and the other is hydrogen or methyl, or R1 and R2 together are an alkylene group having 2 to 4 carbon atoms. The 2-(2',2',2'-tribromoethyl)- 4-chlorocyclobutan-1-ones of the formula I are valuable intermediates for the preparation of 2-(2',2'- dibromovinyl)-cyclopropane-1- carboxylic acids and esters thereof having an insecticidal action.

公开(公告)号：CA1132583A

公开(公告)日：1982-09-28

申请号：CA350165

申请日：1980-04-18

Applicant: CIBA GEIGY AG

Inventor： BUEHLER NIKLAUS ,  BAUMANN MARCUS ,  BELLUS DANIEL ,  STURM ELMAR

IPC: A01N37/32 ,  C07C51/353 ,  C07D209/52 ,  A01N43/38

Abstract: Cyclobutanecarboxylic acid imides of the formula I (I) wherein one of R1 and R6 is hydrogen, methyl or ethyl, and the other is methyl or ethyl, R2 and R3 independently of one another are each hydrogen, fluorine or methyl, or R2 is acetoxy or chlorine whilst R3 is hydrogen, and wherein R4 is hydrogen, methyl or chlorine, and R5 is hydrogen or methyl, whereby R3 and R4 together can also form an additional bond in the four-membered ring, are suitable for combating various fungi and have a particularly excellent action against Botrytis. They can be produced in an especially advantageous manner by photochemical ¢2+2! cycloaddition of alkenes or alkines with for example appropriately substituted maleic acid-(3,5-dichlorophenyl)-amides.

公开(公告)号：SU959621A3

公开(公告)日：1982-09-15

申请号：SU2596900

申请日：1978-03-28

Applicant: CIBA GEIGY AG

Inventor： GROJTER KHANS ,  MARTIN PER ,  BELLUS DANIEL

IPC: C07C45/45 ,  C07C49/457 ,  C07C53/50 ,  C07C57/54 ,  C07C57/76 ,  C07C59/115 ,  C07D307/33 ,  C07D307/94

公开(公告)号：CA1128950A

公开(公告)日：1982-08-03

申请号：CA320890

申请日：1979-02-06

Applicant: CIBA GEIGY AG

Inventor： ZWEIFEL HANS ,  SCHILLING WALTER ,  STORNI ANGELO ,  BELLUS DANIEL

IPC: C07D209/50 ,  C07C61/39 ,  C07D209/58 ,  C07D209/66 ,  C07D209/70 ,  C07D209/76 ,  C07D405/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C08F8/30 ,  C08F20/00 ,  C08F20/34 ,  C08F20/36 ,  C08G73/00 ,  C08G73/10 ,  C08G85/00 ,  G03F7/038 ,  C07D209/56

Abstract: Nov? tricyclic imidyl derivatives, for example those of the formula n=1 or 2, Y= a bridge member and X = a functional group! are described. The novel tricyclic imidyl derivatives are suitable for the preparation of photocrosslinkable polymers by incorporation into existing polymer chains or by building up the polymer chain from tricyclic imidyl derivatives, according to the definition, with suitable The photocrosslinkable polymers obtained by this means can be used, for example, to produce printing plates for the offset printi? process and especially as photoresists.

公开(公告)号：DD149065A5

公开(公告)日：1981-06-24

申请号：DD21732979

申请日：1979-12-03

Applicant: CIBA GEIGY AG

Inventor： STEINER EGINHARD ,  MARTIN PIERRE ,  BELLUS DANIEL

IPC: C07C255/17 ,  C07D213/61

Abstract: A novel process for producing 2,3,5-trichloropyridine is described. The process comprises the addition reaction of trichloroacetaldehyde with acrylonitrile in the presence of a catalyst, and the subsequent cyclization of the intermediately formed 2,4,4-trichloro-4-formylbutyronitrile, with the splitting-off of water, to give 2,3,5-trichloropyridine. 2,4,4-Trichloro-4-formylbutyronitrile occurring as an intermediate product in the process according to the invention is a novel compound. It can be produced by the addition reaction of trichloroacetaldehyde with acrylonitrile in the presence of a catalyst. 2,3,5-Trichloropyridine can be used as intermediate for the production of herbicidal active substances.