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公开(公告)号：WO2019034222A1
公开(公告)日：2019-02-21
申请号：PCT/DK2018/050199
申请日：2018-08-16
Applicant: COLOPLAST A/S
Inventor： VANGE, Jakob
Abstract: Coatings for medical devices, e.g. urinary catheters, are provided, which comprise photoinitiator monomers with acrylamide photoinitiator functionality.
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2.发明申请DEGRADABLE HYDROPHILIC BLOCK COPOLYMERS WITH IMPROVED BIOCOM PATIBILΠ FOR SOFT TISSUE REGENERATION 审中-公开具有改进的生物体肥料的可降解的亲水性嵌段共聚物？ 用于软组织再生
公开(公告)号：WO2007101443A1
公开(公告)日：2007-09-13
申请号：PCT/DK2007/000115
申请日：2007-03-07
Applicant: COLOPLAST A/S , VANGE, Jakob , SCHWACH-ABDELLAOUI, Khadija , EVERLAND, Hanne , NIELSEN, Peter, Sylvest , NIELSEN, Brian , JESPERSEN, Lene, Karin , NIELSEN, Lene, Feldskov
Inventor： VANGE, Jakob , SCHWACH-ABDELLAOUI, Khadija , EVERLAND, Hanne , NIELSEN, Peter, Sylvest , NIELSEN, Brian , JESPERSEN, Lene, Karin , NIELSEN, Lene, Feldskov
CPC classification number: C08G63/664 , A61L15/26 , A61L15/425 , A61L27/18 , A61L27/56 , C08G2261/126 , C08J9/28 , C08J2201/0482 , C08J2201/0484 , C08J2367/04 , C12N5/0068 , C12N2533/30 , C12N2533/40 , Y10T428/249958 , C08L67/04
Abstract: The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O-(CHR 1 CHR 2 O) n -B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [-CH(CH 3 )-COO-] and (ii) glycolide units [-CH 2 -COO-] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C 1-6 -alkyl or hydroxy protecting groups, one of R 1 and R 2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [-(CHR 1 CHR 2 O)-] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.
Abstract translation: 本申请公开了可生物降解的聚合物，包括这种聚合物的多孔和其它材料，以及这种材料的各种医学用途，包括用作支撑细胞粘附的支架或用于组织再生的生长中的用途。 该聚合物具有下式：其中A是聚（丙交酯 - 共 - 乙交酯），其中A是聚（丙交酯 - 共 - 乙交酯） ）残基，（i）丙交酯单元[-CH（CH 3） - COO-]的摩尔比和（ii）乙交酯单元[-CH 2 -COO- ]在聚（丙交酯 - 共 - 乙交酯）残基中的比例在80:20至10:90的范围内，B是聚（丙交酯 - 共 - 乙交酯）残基或氢，C 1-6 - N 1 - 烷基或羟基保护基，R 1和R 2之一是氢或甲基，另一个是氢，n是10-1000，摩尔比 的（iii）聚亚烷基二醇单元[ - （CHR 1 CH 2 O） - ]与（i）丙交酯单元和（ii）乙二醇单元的组合 聚（丙交酯 - 共 - 乙交酯）残基最多为14:86，共聚物的分子量至少为20,000g / mol。
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3.发明公开BIOSYNTHETIC CARTILAGINOUS MATRIX AND METHODS FOR THEIR PRODUCTION 审中-公开VERFAHREN ZU IHRER HERSTELLUNG的BIOSYNTHETISCHE KNORPELMATRIX
公开(公告)号：EP2259806A1
公开(公告)日：2010-12-15
申请号：EP09714829.0
申请日：2009-03-02
Applicant: Coloplast A/S , Interface Biotech A/S
Inventor： EVERLAND, Hanne , SAMUELSEN, Peter , VANGE, Jakob , CLAUSEN, Christian
CPC classification number: A61L27/58 , A61L27/3817 , A61L27/3852 , A61L27/54 , A61L2300/414
Abstract: An isolated, acellular biosynthetic cartilaginous matrix substantially devoid of synthetic biodegradable scaffold structure is provided. Through a method with the steps of a) contacting
in vitro a population of chondrogenic cells with a synthetic biodegradable scaffold; b) culturing
in vitro for a period of time said chondrogenic cells within said synthetic biodegradable scaffold so that the chondrogenic cells produce a biosynthetic cartilaginous matrix; c) substantially removing any antigen derived from said chondrogenic cells a matrix suitable of implantation into a living individual mammal, such as a human being is obtained.Abstract translation: 提供了一种基本上没有合成可生物降解的脚手架结构的分离的，无细胞的生物合成软骨基质。 通过以下步骤的方法：a）将体细胞群体的软骨细胞与合成的可生物降解的支架接触; b）在体外培养所述合成可生物降解的支架内所述软骨形成细胞的一段时间，使得软骨形成细胞产生生物合成软骨基质; c）基本上除去源自所述软骨形成细胞的任何抗原，获得适合植入活体个体哺乳动物（例如人）的基质。
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公开(公告)号：WO2018177488A1
公开(公告)日：2018-10-04
申请号：PCT/DK2018/050053
申请日：2018-03-22
Applicant: COLOPLAST A/S
Inventor： VANGE, Jakob , SEHNAL, Petr , JEPSON, David , TOWNS, Andrew
IPC: C07C231/06 , C07C233/49
Abstract: Acrylamide photoinitiators are provided, in which a photoinitiator moiety and an acrylamide are incorporated into the photoinitiator structure.
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公开(公告)号：WO2013007266A1
公开(公告)日：2013-01-17
申请号：PCT/DK2012/050264
申请日：2012-07-10
Applicant: COLOPLAST A/S , EVERLAND, Hanne , OSTHER, Kurt , VANGE, Jakob , NIELSEN, Lene Feldskov
Inventor： EVERLAND, Hanne , OSTHER, Kurt , VANGE, Jakob , NIELSEN, Lene Feldskov
CPC classification number: A61F13/00991 , A61L15/26 , A61L15/32 , A61L15/38 , A61L15/425 , A61L2400/04 , C08L75/04
Abstract: The present invention relates to method of preparing an absorbent wound care device comprising an active agent on a wound contacting surface, such as e.g. a protein or an enzyme, by the use of electrospraying, and a wound care device obtained by said method. The invention further relates to a wound care device comprising Thrombin and a polyurethane foam, and a method of treating bleeding.
Abstract translation: 本发明涉及一种制备吸收性伤口护理装置的方法，其包括在伤口接触表面上的活性剂， 蛋白质或酶，通过使用电喷雾，以及通过所述方法获得的伤口护理装置。 本发明还涉及包含凝血酶和聚氨酯泡沫的伤口护理装置以及治疗渗血的方法。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2011003422A1
公开(公告)日：2011-01-13
申请号：PCT/DK2010/050176
申请日：2010-07-06
Applicant: COLOPLAST A/S , EVERLAND, Hanne , NIELSEN, Lene, Feldskov , VANGE, Jakob , GALLEGO, Monica, Ramos
Inventor： EVERLAND, Hanne , NIELSEN, Lene, Feldskov , VANGE, Jakob , GALLEGO, Monica, Ramos
CPC classification number: A61F2/0045 , A61B17/0057 , A61F2/0063 , A61L27/12 , A61L27/38 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/236 , A61L2300/414 , A61L2300/43 , A61L2300/604 , C08L67/04
Abstract: The present invention relates to new reinforced biodegradable scaffolds for soft tissue regeneration, as well as methods for support and for augmentation and regeneration of living tissue, wherein a reinforced biodegradable scaffold is used for the treatment of indications, where increased strength and stability is required besides the need for regeneration of living tissue within a patient. The present invention further relates to the use of scaffolds together with cells or tissue explants for soft tissue regeneration, such as in the treatment of a medical prolapse, such as rectal or pelvic organ prolapse, or hernia.
Abstract translation: 本发明涉及用于软组织再生的新的增强的可生物降解支架，以及用于支撑和增加和再生生物体组织的方法，其中增强的可生物降解的支架用于治疗适应症，其中需要增加强度和稳定性 需要在患者体内再生活组织。 本发明进一步涉及支架与细胞或组织外植体一起用于软组织再生，例如治疗医学脱垂，例如直肠或盆腔器官脱垂或疝气。
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公开(公告)号：WO2009106642A1
公开(公告)日：2009-09-03
申请号：PCT/EP2009/052432
申请日：2009-03-02
Applicant: COLOPLAST A/S , EVERLAND, Hanne , SAMUELSEN, Peter , VANGE, Jakob , CLAUSEN, Christian , INTERFACE BIOTECH A/S
Inventor： EVERLAND, Hanne , SAMUELSEN, Peter , VANGE, Jakob , CLAUSEN, Christian
CPC classification number: A61L27/58 , A61L27/3817 , A61L27/3852 , A61L27/54 , A61L2300/414
Abstract: An isolated, acellular biosynthetic cartilaginous matrix substantially devoid of synthetic biodegradable scaffold structure is provided. Through a method with the steps of a) contacting in vitro a population of chondrogenic cells with a synthetic biodegradable scaffold; b) culturing in vitro for a period of time said chondrogenic cells within said synthetic biodegradable scaffold so that the chondrogenic cells produce a biosynthetic cartilaginous matrix; c) substantially removing any antigen derived from said chondrogenic cells a matrix suitable of implantation into a living individual mammal, such as a human being is obtained.
Abstract translation: 提供了一种基本上没有合成可生物降解的脚手架结构的分离的，无细胞的生物合成软骨基质。 通过以下步骤的方法：a）将体细胞群体的软骨细胞与合成的生物可降解支架接触; b）在体外培养所述合成可生物降解的支架内的所述软骨形成细胞的一段时间，使得软骨形成细胞产生生物合成的软骨基质; c）基本上除去源自所述软骨形成细胞的任何抗原，获得适合植入活体个体哺乳动物（例如人）的基质。
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8.发明申请COMPOSITIONS AND METHODS FOR AUGMENTATION AND REGENERATION OF LIVING TISSUE IN A SUBJECT 审中-公开用于补充和再生一个主体的生活组织的组合物和方法
公开(公告)号：WO2009106641A2
公开(公告)日：2009-09-03
申请号：PCT/EP2009/052431
申请日：2009-03-02
Applicant: COLOPLAST A/S , EVERLAND, Hanne , SAMUELSEN, Peter , VANGE, Jakob , CLAUSEN, Christian , GALLEGO, Monica Ramos
Inventor： EVERLAND, Hanne , SAMUELSEN, Peter , VANGE, Jakob , CLAUSEN, Christian , GALLEGO, Monica Ramos
CPC classification number: A61L27/3604 , A61L27/18 , A61L27/38 , A61L27/56 , A61L2400/06 , Y10T428/2982 , C08L67/04
Abstract: The present invention provides for a composition, for augmentation and regeneration of living tissue in a subject, comprising a population of porous microparticles of a biodegradable polymer, one or more mammalian cell populations, and optionally, a biocompatible adhesive.
Abstract translation: 本发明提供用于增加和再生受试者中的活组织的组合物，其包含生物可降解聚合物，一种或多种哺乳动物细胞群和任选的生物相容性粘合剂的多孔微粒群。
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公开(公告)号：EP3601213A1
公开(公告)日：2020-02-05
申请号：EP18714437.3
申请日：2018-03-22
Applicant: Coloplast A/S
Inventor： VANGE, Jakob , SEHNAL, Petr , JEPSON, David , TOWNS, Andrew
IPC: C07C231/06 , C07C233/49
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公开(公告)号：EP2729190B1
公开(公告)日：2015-09-09
申请号：EP12737197.9
申请日：2012-07-10
Applicant: Coloplast A/S
Inventor： EVERLAND, Hanne , OSTHER, Kurt , VANGE, Jakob , NIELSEN, Lene Feldskov
CPC classification number: A61F13/00991 , A61L15/26 , A61L15/32 , A61L15/38 , A61L15/425 , A61L2400/04 , C08L75/04
Abstract: The present invention relates to method of preparing an absorbent wound care device comprising an active agent on a wound contacting surface, such as e.g. a protein or an enzyme, by the use of electrospraying, and a wound care device obtained by said method. The invention further relates to a wound care device comprising Thrombin and a polyurethane foam, and a method of treating bleeding.
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