公开(公告)号：DE69733426D1

公开(公告)日：2005-07-07

申请号：DE69733426

申请日：1997-10-03

Applicant: CORNING INC

Inventor： BOOKBINDER C ,  FEWKES J ,  GRIFFIN A ,  SMITH M ,  TENNENT L

IPC: B05D5/08 ,  B01L99/00 ,  B05D3/02 ,  C07H21/00 ,  C08J7/04 ,  C08J7/06 ,  G01N33/543 ,  B08B3/00 ,  B08B7/00 ,  C11D1/83 ,  C11D1/835 ,  C11D3/30 ,  C11D3/43

Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

公开(公告)号：DE69733426T2

公开(公告)日：2006-04-27

申请号：DE69733426

申请日：1997-10-03

Applicant: CORNING INC

Inventor： BOOKBINDER C ,  FEWKES J ,  GRIFFIN A ,  SMITH M ,  TENNENT L

IPC: B05D5/08 ,  B08B3/00 ,  B01L99/00 ,  B05D3/02 ,  B08B7/00 ,  C07H21/00 ,  C08J7/04 ,  C08J7/06 ,  C11D1/83 ,  C11D1/835 ,  C11D3/30 ,  C11D3/43 ,  G01N33/543

Abstract: Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

公开(公告)号：DE69719965T2

公开(公告)日：2004-03-04

申请号：DE69719965

申请日：1997-04-21

Applicant: CORNING INC

Inventor： FEWKES J ,  GREENE E ,  MORENA ROBERT ,  SMITH M

IPC: C03C8/14 ,  C03C8/16 ,  C03C8/20 ,  C03C8/24

Abstract: PCT No. PCT/US97/06926 Sec. 371 Date Oct. 8, 1998 Sec. 102(e) Date Oct. 8, 1998 PCT Filed Apr. 21, 1997 PCT Pub. No. WO97/41078 PCT Pub. Date Nov. 6, 1997A method of controlling the rheology of a sealing glass paste which comprises incorporating a fine inorganic powder in the paste as a mill addition to impart a steep rheology curve to the paste so that the paste resists flow while at rest, but flows readily when shear stress is applied, the amount of inorganic powder incorporated being not over about 10% by weight.

公开(公告)号：DE69719965D1

公开(公告)日：2003-04-24

申请号：DE69719965

申请日：1997-04-21

Applicant: CORNING INC

Inventor： FEWKES J ,  GREENE E ,  MORENA ROBERT ,  SMITH M

IPC: C03C8/14 ,  C03C8/16 ,  C03C8/20 ,  C03C8/24

Abstract: PCT No. PCT/US97/06926 Sec. 371 Date Oct. 8, 1998 Sec. 102(e) Date Oct. 8, 1998 PCT Filed Apr. 21, 1997 PCT Pub. No. WO97/41078 PCT Pub. Date Nov. 6, 1997A method of controlling the rheology of a sealing glass paste which comprises incorporating a fine inorganic powder in the paste as a mill addition to impart a steep rheology curve to the paste so that the paste resists flow while at rest, but flows readily when shear stress is applied, the amount of inorganic powder incorporated being not over about 10% by weight.