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    BATH FOR A PLURALITY OF APERTURE TUBES
    6.
    发明专利
    BATH FOR A PLURALITY OF APERTURE TUBES 未知

    公开(公告)号：GB1268790A

    公开(公告)日：1972-03-29

    申请号：GB3634069

    申请日：1969-07-18

    Applicant: COULTER ELECTRONICS

    Inventor： HOGG WALTER ROBERT

    IPC: G01N15/12

    Abstract: 1,268,790. Electro-physical measurement, particle analysis. COULTER ELECTRONICS Ltd. July 18, 1969 [July 22, 1968], No. 36340/69. Heading G1N. In a liquid sample analysis bath e.g. for a multi-aperture-tube apparatus as described in Specification 1, 232, 707. The sample supply pipe enters through the bottom of the bath (instead of the top and has a preferably catenoidal configuration to promote smooth flow of liquid into the bath.

    7.
    发明专利
    未知

    公开(公告)号：DE2534955A1

    公开(公告)日：1976-02-19

    申请号：DE2534955

    申请日：1975-08-05

    Applicant: COULTER ELECTRONICS

    Inventor： HOGG WALTER ROBERT ,  COULTER WALLACE HENRY

    IPC: G01N15/10 ,  G01N15/02

    Abstract: An apparatus for determining the correct particle sizes at predetermined percentiles of the size distribution of a particulate system having a known size distribution characteristic such as for example a normal or log-normal size distribution, wherein a portion of the particles are too small to be measured. The particulate system is first passed through a particle detecting device which can be of the Coulter type. The particle detecting device produces particle pulses proportional to the size of the particles in the particulate system which can be measured. At least three percentile size determining circuits receive the particle pulses and develop first, second and third particle size signals respectively, indicating the size of the particles in the particulate system at the first, second and third predetermined percentiles. Two of the size signals are combined in a particular manner based on the known size distribution characteristic for the type of particulate system to yield a combined signal which approximates or is and estimate of the third percentile signal. The combined signal is compared with the measured third signal to obtain an error signal. The error signal is used in turn to add into all three size percentile circuits compensation or correction signals for the total volume of particules too small to be included in the measurements. This process causes the error signal to decrease toward zero, and results in all three circuits having outputs truly representative of their nominal percentiles.

    8.
    发明专利
    未知

    公开(公告)号：DE2449701A1

    公开(公告)日：1975-05-07

    申请号：DE2449701

    申请日：1974-10-18

    Applicant: COULTER ELECTRONICS

    Inventor： HOGG WALTER ROBERT

    IPC: G01N1/28 ,  G01N15/10 ,  G01N15/14 ,  G01N33/48 ,  G01N33/49 ,  G06M11/00 ,  G06T1/00 ,  G01N33/16 ,  G01N15/00 ,  G06K9/16

    Abstract: 1485284 Characterization of suspended particles COULTER ELECTRONICS Inc 18 Oct 1974 [19 Oct 1973 9 Aug 1974] 45323/74 Heading G1B Apparatus for obtaining information on the characteristics of particles in a liquid suspension comprises a particle scanning device 14 comprising means for containing a quantity of particulate suspension, a sensing zone responding to passage of each particle to produce a signal representing at least one physical characteristic of the particle, means to move the suspension in a stream 27 from the container through the sensing zone and out of the particle scanning device, means for producing signals representing the temporal pattern generated by the passing of the successive particles through the sensing zone with the particles spaced along the stream in a spatial pattern and means for preserving the signals representing the temporal pattern with each signal identified in the pattern with the particle producing it, a substrate 48 arranged to intercept the stream emerging from the scanning device, means for effecting relative movement between the substrate and the stream whereby the stream, which may be continuous or in droplet form, is laid down as a track on the surface of the substrate with the spatial arrangement of the particles preserved on the substrate surface and means 40, 36 for correlating the spatial and temporal patterns to match each of the particles in the track with the signals representing the physical characteristics of the particles. The substrate may be a slide (18), Fig. 1 (not shown), having a surface of frosted or fritted glass to assist in the retention of droplets of suspension, or a pressed paper, or resin optionally in the form of a tape as shown, when the suspension medium is sucked away from the deposited particle. The tape or slide carrying the particles may be passed through a staining bath 56. The tape after staining is scanned by close circuit television scanning device 40 which measures the distances between successive particles, the speed of relative movement of microscope and tape being the same as that between scanning device and tape, so that the measured physical characteristic for each particle can be correlated with its physical position on the slide using a computer (36). In the embodiment of Fig. 1 (not shown), the slide (18) is scanned by an optical microscope. Movement of the slide under the microscope can cease to allow e.g. observation of individual particles provided that the proper rate of movement is maintained between particles. In the embodiment of Fig. 3 (not shown), a slide (18) may be placed on a carriage movable along two axes under manual control, the position of each particle in the track being characterized by two scale readings.

    9.
    发明专利
    未知

    公开(公告)号：DE2438401A1

    公开(公告)日：1975-02-27

    申请号：DE2438401

    申请日：1974-08-09

    Applicant: COULTER ELECTRONICS

    Inventor： LIEDHOLZ GERHARD ADOLPH ,  COULTER WALLACE HENRY ,  HOGG WALTER ROBERT

    IPC: G01N15/12 ,  G01N33/49 ,  G01R27/26 ,  G01N27/02

    Abstract: The electrical sensing circuitry includes a power supply and a signal-detecting circuit which are coupled through the resistance of an electrolyte in a liquid in an aperture of a particle-analyzing device between sensing electrodes positioned on either side of the aperture. The liquid containing an electrolyte and the passage of a liquidborne particle through the aperture causes a change in the resistance of the aperture thereby generating a signal which is detected by the signal-detecting circuit. The parameters of the circuit elements are chosen to provide circuit relationships which render the particle-generated signal independent of the diameter of the aperture. This is achieved by utilizing a power source having a low output impedance and a signal-detecting circuit which has a low input impedance for both D.C. and A.C., namely, at the signal frequencies of the signals sensed. The electrical circuitry also may include a conductivity monitoring circuit which may utilize one or more of the sensing electrodes and/or additional electrodes for monitoring changes in conductivity of the electrolyte and for relating these changes in conductivity to the particle-generated signals sensed by the signal-detecting circuit to alter those signals so as to render them independent of electrolyte resistivity.

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