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公开(公告)号：CA1138220A
公开(公告)日：1982-12-28
申请号：CA391038
申请日：1981-11-26
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS , KREISELMAN ROBERT L
IPC: G01N21/75
Abstract: Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
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公开(公告)号：CA939527A
公开(公告)日：1974-01-08
申请号：CA64283
申请日：1969-10-06
Applicant: COULTER ELECTRONICS
Inventor： DORMAN ERVIN L JR , KLEIN ROBERT I , KREISELMAN ROBERT L , COULTER WALLACE H
Abstract: 1276105 Automatic analysis COULTER ELECTRONICS Inc 6 Oct 1969 [10 Oct 1968] 48991/69 Heading B1X [Also in Divisions G1 and G2] Apparatus for dispensing diluent from reservoir 20 into cuvette 50 for measurement comprises spring-loaded piston 32 moving in cylinder 28, one end of the cylinder being connectable to atmosphere through normally closed valve V1B and the other end being connected to liners 22, 26 as shown. When the sample in the cuvette has been measured, valve V3 is opened under control of programming device 72 and the sample is tucked away by pump 46. Valve V3 is closed, valve VIA is closed and valve V1B opened to produce atmospheric pressure in line 36. Piston 32 then moves to force diluent already in line 26 into the cuvette.
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公开(公告)号：CA1138221A
公开(公告)日：1982-12-28
申请号：CA391039
申请日：1981-11-26
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS , KREISELMAN ROBERT L
IPC: G01N35/04
Abstract: Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time, The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
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Patent Agency Ranking
公开(公告)号：CA1116430A
公开(公告)日：1982-01-19
申请号：CA305783
申请日：1978-06-19
Applicant: COULTER ELECTRONICS
Inventor： GINSBERG GUENTER , HORNE THOMAS , KREISELMAN ROBERT L
Abstract: Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time. The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
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公开(公告)号：US3696399A
公开(公告)日：1972-10-03
申请号：US3696399D
申请日：1970-09-11
Applicant: COULTER ELECTRONICS
Inventor： KLEIN ROBERT T , KREISELMAN ROBERT L
CPC classification number: G01N15/1227
Abstract: By expanding the input to an A to D converter, and also establishing an offset or low end threshold for pulse data as it is being processed by the A to D converter to a multichannel pulse amplitude memory, the fixed number of memory channels are effectively expanded and a selectively small portion of the channel range can be examined in increased detail. This method and apparatus differs from the prior art range expanding in that it operates upon pulse data during its collection and not after receipt in the memory; thus, a plurality of memory channels can act as a single and wider channel.
Abstract translation: 通过将输入扩展到A到D转换器，并且还在由A到D转换器处理到多通道脉冲幅度存储器的同时建立脉冲数据的偏移或低位阈值，固定数量的存储器通道被有效地扩展 并且可以更详细地检查通道范围的选择性小部分。 该方法和装置与现有技术的范围扩大不同之处在于，其在收集期间在脉冲数据上操作，而不是在接收到存储器中之后操作; 因此，多个存储器通道可以用作单个和更宽的通道。
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6.发明授权
公开(公告)号：US3622795A
公开(公告)日：1971-11-23
申请号：US3622795D
申请日：1968-10-10
Applicant: COULTER ELECTRONICS
Inventor： DORMAN ERVIN L JR , KLEIN ROBERT I , KREISELMAN ROBERT L , COULTER WALLACE H
IPC: G01J3/51 , G01G3/02 , G01G3/08 , G01G23/14 , G01N21/05 , G01N21/85 , G01N21/26 , E03B , G01N33/16
Abstract: Apparatus to be used in making hemoglobin determinations of samples of blood and other colorimetric fluid tests, which includes colorimetric computing circuitry and a flow-through cuvette in the same housing, the flow-through cuvette being normally covered by a lid which is raised by the operator when pouring the test sample into the cuvette. The construction is such that the technician need use only one hand for raising the lid and pouring the sample, leaving the other hand free for making notes or other purpose. The lid movement initiates programming means and the operating cycle, which includes: draining a blanking fluid with which the cuvette is filled between the cycles of use of the apparatus, accepting the sample poured into the cuvette, making the colorimetric measurement thereof, emptying the sample from the cuvette, rinsing the cuvette, and refilling the cuvette with the blanking fluid for the next measuring cycle. All fluid movement is achieved through the use of a system operating in conjunction with suitable valves, solenoids and at least one spring-return operated, piston-type liquid dispenser. A novel cuvette construction provides concentric fluid-receiving mouths leading to inner and outer receptacles, the inner being the receptacle for the sample fluid, the outer being an overflow basin. The receptacles lead to respective independent drains, the inner being provided with a light transmitting section at which the fluid is traversed by a beam of radiant energy.
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公开(公告)号：CA1159277A
公开(公告)日：1983-12-27
申请号：CA382631
申请日：1981-07-28
Applicant: COULTER ELECTRONICS
Inventor： KOLBER STEVEN N , MARINO ANTHONY , KREISELMAN ROBERT L
Abstract: OPTICAL TIMING AND ANALOG-TO-DIGITAL CONVERSION METHOD AND APPARATUS An optical timing and A/D conversion method and apparatus for converting analog signals obtained by movement of a plurality of reaction vessels relative to one or more beams of light from analog to digital signals. The sample signals are obtained each time a reaction vessel passes through a beam of light. The converted digital signals indicate the absorbance of the respective vessels and their contents. Each of the reaction vessels or cuvettes has translucent wall portions providing a radiation path therethrough for the light beams which may be monitored by photometer means in a chemical reaction analyzer. The vessels are repeatedly passed through the light beams of the photometer means as chemical reactions take place therein, the purpose being to monitor the changes in the reaction of the fluids therein by measuring the changes in the absorbance of the vessel and fluids. The sample interval of the analog signal is repeatable for each vessel for each light beam and may be shifted to select the best portion of the analog signal generated as the vessel passes through the particular light beam. The A/D conversion also may eliminate the dark sample or noise error between the light beams and the reaction vessels and may eliminate the variations in the sample signals caused by changes in the rate of relative movement between the beams and vessels and changes in the velocity of the rotating beam.
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公开(公告)号：GB1276105A
公开(公告)日：1972-06-01
申请号：GB4899169
申请日：1969-10-06
Applicant: COULTER ELECTRONICS
Inventor： DORMAN ERVIN L JR , KLEIN ROBERT I , KREISELMAN ROBERT L , COULTER WALLACE H
Abstract: 1276105 Automatic analysis COULTER ELECTRONICS Inc 6 Oct 1969 [10 Oct 1968] 48991/69 Heading B1X [Also in Divisions G1 and G2] Apparatus for dispensing diluent from reservoir 20 into cuvette 50 for measurement comprises spring-loaded piston 32 moving in cylinder 28, one end of the cylinder being connectable to atmosphere through normally closed valve V1B and the other end being connected to liners 22, 26 as shown. When the sample in the cuvette has been measured, valve V3 is opened under control of programming device 72 and the sample is tucked away by pump 46. Valve V3 is closed, valve VIA is closed and valve V1B opened to produce atmospheric pressure in line 36. Piston 32 then moves to force diluent already in line 26 into the cuvette.
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