公开(公告)号：KR870000354B1

公开(公告)日：1987-03-05

申请号：KR840008498

申请日：1984-12-28

Applicant: DEGUSSA

Inventor： SCHEFFLER GERHARD ,  ENGEL JUERGEN ,  JAKOVLEV VLADIMIR ,  NICKEL BERND ,  THIEMER KLAUS

IPC: C07D401/12 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/46 ,  A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D211/54 ,  C07D213/643 ,  C07D213/70 ,  C07D213/71 ,  C07D213/89 ,  C07D243/00 ,  C07D317/00 ,  C07D405/12 ,  C07D405/14 ,  C07D451/02 ,  C07D451/06 ,  C07D453/02

公开(公告)号：FI84062B

公开(公告)日：1991-06-28

申请号：FI845126

申请日：1984-12-27

Applicant: DEGUSSA

Inventor： SCHEFFLER GERHARD ,  ENGEL JUERGEN ,  JAKOVLEV VLADIMIR ,  NICKEL BERND ,  THIEMER KLAUS

IPC: C07D401/12 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/46 ,  A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D211/54 ,  C07D213/643 ,  C07D213/70 ,  C07D213/71 ,  C07D213/89 ,  C07D243/00 ,  C07D317/00 ,  C07D405/12 ,  C07D405/14 ,  C07D451/02 ,  C07D451/06 ,  C07D453/02

Abstract: There are disclosed pyridine-2-ethers and pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring corresponding to the formula I the pyridine-N-oxides and/or amine oxides thereof and the pharmaceutically acceptable salts thereof. The compounds show analgesic activity.

公开(公告)号：DK157016C

公开(公告)日：1990-03-26

申请号：DK198785

申请日：1985-05-02

Applicant: DEGUSSA

Inventor： HETTCHE HELMUT ,  EMIG PETER ,  ENGEL JUERGEN

IPC: A61K31/19 ,  A61K31/191 ,  A61K31/44 ,  A61P25/04 ,  A61P29/00 ,  C07C51/00 ,  C07C59/105 ,  C07C67/00 ,  C07D213/75

Abstract: There is disclosed 2-amino-3-ethoxycarbonylamino-6-(p-fluoro-benzylamino)-pyridine gluconate, process for its production and pharmaceutical preparations which contain this material.

公开(公告)号：FI77649B

公开(公告)日：1988-12-30

申请号：FI813623

申请日：1981-11-16

Applicant: DEGUSSA

Inventor： ENGEL JUERGEN

IPC: A61K31/135 ,  C07C20060101 ,  C07C27/00 ,  C07D263/04 ,  C07C97/10 ,  C07C91/16 ,  C07C91/34

公开(公告)号：DD259848A5

公开(公告)日：1988-09-07

申请号：DD29314686

申请日：1986-07-30

Applicant: DEGUSSA

Inventor： ENGEL JUERGEN ,  KUTSCHER BERNHARD ,  OEPEN GERHARD ,  NIEBCH GEORG ,  METZENAUER PETER

IPC: A61K31/135 ,  A61K20060101 ,  A61K31/22 ,  A61P9/00 ,  C07C20060101 ,  C07C67/00 ,  C07C213/00 ,  C07C225/10 ,  C07C97/065

公开(公告)号：HU194803B

公开(公告)日：1988-03-28

申请号：HU192882

申请日：1982-06-15

Applicant: DEGUSSA

Inventor： ENGEL JUERGEN ,  OEPEN GERHARD

IPC: A61K31/12 ,  A61K31/13 ,  A61K31/135 ,  C07C20060101 ,  C07C91/04 ,  C07C97/065

公开(公告)号：HU191643B

公开(公告)日：1987-03-30

申请号：HU116884

申请日：1984-03-23

Applicant: DEGUSSA

Inventor： OEPEN GERHARD ,  ENGEL JUERGEN ,  JAKOVLEV VLADIMIR ,  THIEMER KLAUS

IPC: C07D295/18 ,  A61K31/495 ,  A61K31/496 ,  A61P25/04 ,  A61P29/00 ,  C07D213/72 ,  C07D213/74 ,  C07D239/42 ,  C07D241/20 ,  C07D295/185 ,  C07D295/10 ,  C07D401/04 ,  C07D403/04 ,  A61K31/435

Abstract: There are prepared new pharmacologically active compounds of the formula: I In formula I R1 is a phenyl radical, pyridyl radical, a pyrimidyl group, or pyrazinyl radical, or a phenyl radical, pyridiyl radical, pyrimidyl radical, or pyrazinyl radical substituted by the radicals R3 and R4 which are the same or different and are hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, C1-C6-alkyl groups C1-C6-alkoxy groups, C3-C6-alkenyloxy groups, C3-C6-cycloalkyloxy groups, phenyl-C1-C4-alkoxy groups, C1-C6-alkylmercapto groups, the nitro group, the amino group, C1-C6-dialkylamino groups, C2-C6-alkanoyl groups, C2-C6-alkanoylamino groups, or C2-C6-alkanoyloxy groups and R2 is the adamantyl group, the 3,3-dimethyl-bicyclo[2.2.1]hept-2-yl radical, a saturated C3-C16-cycloalkenyl radical and alk is a straight or branched C1-C6 alkyl chain.

公开(公告)号：NO863078L

公开(公告)日：1987-02-02

申请号：NO863078

申请日：1986-07-30

Applicant: DEGUSSA

Inventor： ENGEL JUERGEN ,  KUTSCHER BERHARD ,  OEPEN GERHARD ,  NIEBCH GEORG ,  METZENAUER PETER

IPC: A61K31/135 ,  A61K31/24 ,  C07C20060101 ,  C07C

公开(公告)号：ZA862138B

公开(公告)日：1986-11-26

申请号：ZA862138

申请日：1986-03-21

Applicant: DEGUSSA

Inventor： ORTH WINFRIED ,  ENGEL JUERGEN ,  EMIG PETER ,  SCHEFFLER GERHARD ,  POHLE HANS

IPC: C07D213/74 ,  C07D213/75 ,  C07D

Abstract: There is described a process for the production of 2-amino-3-nitro-6-(4-fluorobenzylamino)-pyridine which consists essentially of reacting 2-amino-3-nitro-6-methoxypyridine with 4-fluorobenzylamine in water at elevated temperature; in a given case the nitro group can be subsequently reduced and a carbethoxy group introduced.

公开(公告)号：DK126886D0

公开(公告)日：1986-03-19

申请号：DK126886

申请日：1986-03-19

Applicant: DEGUSSA

Inventor： ORTH WINFRIED ,  ENGEL JUERGEN ,  EMIG PETER ,  SCHEFFLER GERHARD ,  POHLE HANS

IPC: C07D213/74 ,  C07D213/75 ,  C07D

Abstract: There is described a process for the production of 2-amino-3-nitro-6-(4-fluorobenzylamino)-pyridine which consists essentially of reacting 2-amino-3-nitro-6-methoxypyridine with 4-fluorobenzylamine in water at elevated temperature; in a given case the nitro group can be subsequently reduced and a carbethoxy group introduced.