公开(公告)号：KR870000354B1

公开(公告)日：1987-03-05

申请号：KR840008498

申请日：1984-12-28

Applicant: DEGUSSA

Inventor： SCHEFFLER GERHARD ,  ENGEL JUERGEN ,  JAKOVLEV VLADIMIR ,  NICKEL BERND ,  THIEMER KLAUS

IPC: C07D401/12 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/46 ,  A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D211/54 ,  C07D213/643 ,  C07D213/70 ,  C07D213/71 ,  C07D213/89 ,  C07D243/00 ,  C07D317/00 ,  C07D405/12 ,  C07D405/14 ,  C07D451/02 ,  C07D451/06 ,  C07D453/02

公开(公告)号：NO164237B

公开(公告)日：1990-06-05

申请号：NO845250

申请日：1984-12-27

Applicant: DEGUSSA

Inventor： SCHEFFLER GERHARD ,  ENGEL JUERGEN ,  JAKOVLEV VLADIMIR ,  NICKEL BERND ,  THIEMER KLAUS

IPC: C07D401/12 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/46 ,  A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D211/54 ,  C07D213/643 ,  C07D213/70 ,  C07D213/71 ,  C07D213/89 ,  C07D243/00 ,  C07D317/00 ,  C07D405/12 ,  C07D405/14 ,  C07D451/02 ,  C07D451/06 ,  C07D453/02

Abstract: There are disclosed pyridine-2-ethers and pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring corresponding to the formula I the pyridine-N-oxides and/or amine oxides thereof and the pharmaceutically acceptable salts thereof. The compounds show analgesic activity.

公开(公告)号：MX154886A

公开(公告)日：1987-12-28

申请号：MX778779

申请日：1979-05-15

Applicant: DEGUSSA

Inventor： ENGEL JURGEN ,  KLEEMANN AXEL ,  POSSELT KLAUS ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/13 ,  C07C91/28

公开(公告)号：AU560579B2

公开(公告)日：1987-04-09

申请号：AU2605784

申请日：1984-03-23

Applicant: DEGUSSA

Inventor： OEPEN GERHARD ,  THIEMER KLAUS ,  ENGEL JURGEN ,  JAKOVLEV VLADIMIR

IPC: C07D295/18 ,  A61K31/495 ,  A61K31/496 ,  A61P25/04 ,  A61P29/00 ,  C07D213/72 ,  C07D213/74 ,  C07D239/42 ,  C07D241/20 ,  C07D295/185

Abstract: There are prepared new pharmacologically active compounds of the formula: I In formula I R1 is a phenyl radical, pyridyl radical, a pyrimidyl group, or pyrazinyl radical, or a phenyl radical, pyridiyl radical, pyrimidyl radical, or pyrazinyl radical substituted by the radicals R3 and R4 which are the same or different and are hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, C1-C6-alkyl groups C1-C6-alkoxy groups, C3-C6-alkenyloxy groups, C3-C6-cycloalkyloxy groups, phenyl-C1-C4-alkoxy groups, C1-C6-alkylmercapto groups, the nitro group, the amino group, C1-C6-dialkylamino groups, C2-C6-alkanoyl groups, C2-C6-alkanoylamino groups, or C2-C6-alkanoyloxy groups and R2 is the adamantyl group, the 3,3-dimethyl-bicyclo[2.2.1]hept-2-yl radical, a saturated C3-C16-cycloalkenyl radical and alk is a straight or branched C1-C6 alkyl chain.

公开(公告)号：FI70205B

公开(公告)日：1986-02-28

申请号：FI791188

申请日：1979-04-11

Applicant: DEGUSSA

Inventor： ENGEL JUERGEN ,  KLEEMANN AXEL ,  POSSELT KLAUS ,  STORMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/135 ,  A61K20060101 ,  A61K31/13 ,  A61K31/137 ,  A61K31/43 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  C07C20060101 ,  C07C67/00 ,  C07C213/00 ,  C07C213/02 ,  C07C213/08 ,  C07C215/30 ,  C07C215/60 ,  C07C221/00 ,  C07C225/06 ,  C07C225/10 ,  C07C225/14 ,  C07C97/10

Abstract: There are prepared compounds of the formula: wherein X is the group >C=O or >CH(OH), Y is the group R2 is hydrogen or C1 to C6 alkyl, R3 is hydrogen or a hydroxy group and R1 is the adamantyl group or a saturated or single unsaturated C3 to C16 cycloalkyl group where the C3 to C16 cycloalkyl group can be substituted by a C1-C4 alkyl group or a halogen atom and their salts. The compounds are useful in dilating the peripheral blood vessels and in lowering blood pressure.

公开(公告)号：ZA8408275B

公开(公告)日：1985-08-28

申请号：ZA8408275

申请日：1984-10-23

Applicant: DEGUSSA

Inventor： SCHEFFLER GERHARD ,  ENGEL JUERGEN ,  JAKOVLEV VLADIMIR ,  NICKEL BERND ,  THIEMER KLAUS

IPC: C07D401/12 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/46 ,  A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D211/54 ,  C07D213/643 ,  C07D213/70 ,  C07D213/71 ,  C07D213/89 ,  C07D243/00 ,  C07D317/00 ,  C07D405/12 ,  C07D405/14 ,  C07D451/02 ,  C07D451/06 ,  C07D453/02 ,  C07D ,  A61K

CPC classification number: C07D213/70 ,  C07D211/54 ,  C07D213/89 ,  C07D401/12 ,  C07D405/14 ,  C07D451/06 ,  C07D453/02

公开(公告)号：NO843906L

公开(公告)日：1985-04-01

申请号：NO843906

申请日：1984-09-28

Applicant: DEGUSSA

Inventor： KLINGLER HARL-HEINZ ,  ENGEL JUERGEN ,  OEPEN GERHARD ,  STROMAN FRITZ ,  THIEMER KLAUS ,  METZENAUER PETER

IPC: C07C45/63 ,  C07C45/71 ,  C07C217/62 ,  C07C

公开(公告)号：NO843906A

公开(公告)日：1985-04-01

申请号：NO843906

申请日：1984-09-28

Applicant: DEGUSSA

Inventor： KLINGLER HARL-HEINZ ,  ENGEL JUERGEN ,  OEPEN GERHARD ,  STROMAN FRITZ ,  THIEMER KLAUS ,  METZENAUER PETER

IPC: C07C45/63 ,  C07C45/71 ,  C07C217/62 ,  C07C

CPC classification number: C07C217/62 ,  C07C45/63 ,  C07C45/71 ,  C07C49/84

公开(公告)号：FI845126A0

公开(公告)日：1984-12-27

申请号：FI845126

申请日：1984-12-27

Applicant: DEGUSSA

Inventor： SCHEFFLER GERHARD ,  ENGEL JUERGEN ,  JAKOVLEV VLADIMIR ,  NICKEL BERND ,  THIEMER KLAUS

IPC: C07D401/12 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/46 ,  A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D211/54 ,  C07D213/643 ,  C07D213/70 ,  C07D213/71 ,  C07D213/89 ,  C07D243/00 ,  C07D317/00 ,  C07D405/12 ,  C07D405/14 ,  C07D451/02 ,  C07D451/06 ,  C07D453/02 ,  C07D

Abstract: There are disclosed pyridine-2-ethers and pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring corresponding to the formula I the pyridine-N-oxides and/or amine oxides thereof and the pharmaceutically acceptable salts thereof. The compounds show analgesic activity.

公开(公告)号：DK613384D0

公开(公告)日：1984-12-20

申请号：DK613384

申请日：1984-12-20

Applicant: DEGUSSA

Inventor： SCHEFFLER GERHARD ,  ENGEL JUERGEN ,  JAKOVLEV VLADIMIR ,  NICKEL BERND ,  THIEMER KLAUS

IPC: C07D401/12 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/46 ,  A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D211/54 ,  C07D213/643 ,  C07D213/70 ,  C07D213/71 ,  C07D213/89 ,  C07D243/00 ,  C07D317/00 ,  C07D405/12 ,  C07D405/14 ,  C07D451/02 ,  C07D451/06 ,  C07D453/02 ,  C07D

Abstract: There are disclosed pyridine-2-ethers and pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring corresponding to the formula I the pyridine-N-oxides and/or amine oxides thereof and the pharmaceutically acceptable salts thereof. The compounds show analgesic activity.