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    Preparation of (S)-cyanohydrin compounds
    3.
    发明专利
    Preparation of (S)-cyanohydrin compounds 未知

    公开(公告)号：DE19703314A1

    公开(公告)日：1997-08-14

    申请号：DE19703314

    申请日：1997-01-30

    Applicant: DEGUSSA

    Inventor： EFFENBERGER FRANZ ,  WAJANT HARALD ,  FOERSTER SIEGFRIED ,  ROOS JUERGEN

    IPC: C07C253/00 ,  C07C253/06 ,  C07C255/16 ,  C07C255/36 ,  C07C255/37 ,  C07D521/00 ,  C12N9/88 ,  C12N11/12 ,  C12P13/00 ,  C12P17/00 ,  C12P17/04

    Abstract: Preparation of (S)-cyanohydrin compounds of formula (I) comprises enzyme-catalysed reaction of carbonyl compounds of formula (II) with hydrocyanic acid, or a substance which releases hydrocyanic acid or CN, in the presence of a catalytic amount of an (S)-oxynitrilase immobilised on a nitrocellulose carrier. R, R' = H; 1-18C alkyl, 2-18C alkenyl or 2-18C alkynyl (all optionally substituted by \- 1 amine, imine, OH, 1-6C alkoxy, halo, carboxyl, 3-20C cycloalkyl and/or Het substituents, where the cyclic substituents are themselves optionally substituted by \- 1 halo, OH, 1-8C alkyl, 2-8C alkenyl or 2-8C alkynyl); or a (hetero)aromatic group containing 5-22 ring atoms, in which up to 4 ring C atoms may be replaced by N, O and/or S atoms, the ring being optionally substituted by \- 1 amine, imine, OH, 1-8C alkoxy, aryloxy, halo, carboxy or 1-22C optionally unsaturated alkyl, where \- 2 of the ring substituents may combine to form a cyclic group; Het = an aromatic ring with up to 22C atoms which is optionally substituted by N, O or S heteroatoms; provided that R' and R are not both H.

    5.
    发明专利
    未知

    公开(公告)号：DK19988A

    公开(公告)日：1988-07-21

    申请号：DK19988

    申请日：1988-01-18

    Applicant: DEGUSSA

    Inventor： EFFENBERGER FRANZ ,  ZIEGLER THOMAS ,  FOERSTER SIEGFRIED

    IPC: C12N9/88 ,  C12P13/00 ,  C12P17/00 ,  C12P41/00

    Abstract: Optically active cyanohydrins are produced by the reaction of an aldehyde with hydrocyanic acid in the presence of D-oxynitrilase (E.C.4.1.2.10). The reaction takes place in an organic solvent which is not miscible with water, but which is saturated with water or an aqueous buffer solution.

    7.
    发明专利
    未知

    公开(公告)号：DE3778864D1

    公开(公告)日：1992-06-11

    申请号：DE3778864

    申请日：1987-10-28

    Applicant: DEGUSSA

    Inventor： EFFENBERGER FRANZ PROF DR ,  ZIEGLER THOMAS DR ,  FOERSTER SIEGFRIED

    IPC: C12N9/88 ,  C12P13/00 ,  C12P17/00 ,  C12P41/00

    Abstract: A prepn. (I) comprises reacting aldehydes with hydrocyanic acid in the presence of D-oxynitrilase and an organic solvent which is immiscible with water but is satd. with water or an aq. buffer soln. Pref. the organic solvent is an aliphatic or aromatic hydrocarbon, a chlorinated aliphatic hydrocarbon, an ether, an alkyl ester of a carboxylic acid or an aliphatic or cycloaliphatic alcohol. The organic solvent is pref. satd. with an aq. buffer of pH 3-8.

    9.
    发明专利
    未知

    公开(公告)号：DK19988D0

    公开(公告)日：1988-01-18

    申请号：DK19988

    申请日：1988-01-18

    Applicant: DEGUSSA

    Inventor： EFFENBERGER FRANZ ,  ZIEGLER THOMAS ,  FOERSTER SIEGFRIED

    IPC: C12N9/88 ,  C12P13/00 ,  C12P17/00 ,  C12P41/00

    Abstract: Optically active cyanohydrins are produced by the reaction of an aldehyde with hydrocyanic acid in the presence of D-oxynitrilase (E.C.4.1.2.10). The reaction takes place in an organic solvent which is not miscible with water, but which is saturated with water or an aqueous buffer solution.

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