公开(公告)号：JPH10168023A

公开(公告)日：1998-06-23

申请号：JP25839597

申请日：1997-09-24

Applicant: DEGUSSA

Inventor： KRILL STEFFEN DR ,  GIRAY GUENES ,  HUTHMACHER KLAUS DR ,  HUEBNER FRANK DR ,  TANNER HERBERT DR

IPC: B01J23/78 ,  B01J27/138 ,  B01J27/232 ,  C07B61/00 ,  C07C45/67 ,  C07C49/603

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing 3,5,5-trimethylcyclohex-3-en-1-one by isomerizing 3,5,5-trimethylcyclohex-2-en-1-one (α-isophorone) in a liquid phase in the presence of a heterogeneous catalyst. SOLUTION: In the case of isomerizing 3,5,5-trimethylcyclohex-2-en-1-one (α-isophorone) in a liquid phase in the presence of a heterogeneous catalyst, an oxide, a mixed oxide or an insoluble salt of an element of the groups IIa, VIII, Ib, IIIa and Va of the periodic table is used as the catalyst and the isomerization is carried out without adding an organic base to produce 3,5,5- trimethylcyclohex-3-en-1-one (β-isophorone).

公开(公告)号：JPH10109955A

公开(公告)日：1998-04-28

申请号：JP25839697

申请日：1997-09-24

Applicant: DEGUSSA

Inventor： KRILL STEFFEN DR ,  GIRAY GUENES ,  HUEBNER FRANK ,  RAINER HAHN ,  HUTHMACHER KLAUS ,  TANNER HERBERT

IPC: B01J23/02 ,  B01J23/75 ,  B01J23/755 ,  C07B61/00 ,  C07C45/67 ,  C07C45/82 ,  C07C45/83 ,  C07C49/603

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound useful as a raw material for medicines with slight formation of by-products in excellent space and time yield and in a high conversion ratio, by taking out a mixture containing a specific amount of β-isophorone from a reaction solution during isomerization of α-isophorone by distillation. SOLUTION: While (A) 3,5,5-trimethylcyclohexa-2-en-1-one is isomerized by (B) a catalyst [e.g. a (mixed) oxide of the groups IIa and VIII of the periodic table, to be concrete, Ca or Mg(mixed) oxide or Co or Ni (mixed) oxide], a mixture containing 0.5-75wt.%, preferably 0.5-40wt.% of 3,5,5- trimethylcyclohexa-3-en-I-one (β-isophorone) is taken out by distillation and β-isophorone is isolated by vacuum distillation from the mixture.

公开(公告)号：AT203508T

公开(公告)日：2001-08-15

申请号：AT97115589

申请日：1997-09-09

Applicant: DEGUSSA

Inventor： KRILL STEFFEN DR ,  GIRAY GUENES ,  HUTHMACHER KLAUS DR ,  HUEBNER FRANK DR ,  TANNER HERBERT DR

IPC: B01J23/78 ,  B01J27/138 ,  B01J27/232 ,  C07B61/00 ,  C07C45/67 ,  C07C49/603

Abstract: Production of 3,5,5-trimethylcyclohex-3-en-1-one ( beta -isophorone) (I) comprises liquid phase isomerisation of 3,5,5-trimethylcyclohex-2-en-1-one ( alpha -isophorone) (II) in the presence of a heterogeneous catalyst comprising an oxide or mixed oxide of a Group IIa, VIII, Ib, IIIa and Va element (or a salt of such an oxide which is insoluble under the reaction conditions) and in the absence of an organic base.

公开(公告)号：DE19639570A1

公开(公告)日：1998-04-02

申请号：DE19639570

申请日：1996-09-26

Applicant: DEGUSSA

Inventor： KRILL STEFFEN DR ,  GIRAY GUENES ,  HUTHMACHER KLAUS DR ,  HUEBNER FRANK DR ,  TANNER HERBERT DR

IPC: B01J23/78 ,  B01J27/138 ,  B01J27/232 ,  C07B61/00 ,  C07C45/67 ,  C07C49/603

Abstract: Production of 3,5,5-trimethylcyclohex-3-en-1-one ( beta -isophorone) (I) comprises liquid phase isomerisation of 3,5,5-trimethylcyclohex-2-en-1-one ( alpha -isophorone) (II) in the presence of a heterogeneous catalyst comprising an oxide or mixed oxide of a Group IIa, VIII, Ib, IIIa and Va element (or a salt of such an oxide which is insoluble under the reaction conditions) and in the absence of an organic base.

公开(公告)号：FI861506A

公开(公告)日：1986-10-12

申请号：FI861506

申请日：1986-04-09

Applicant: DEGUSSA

Inventor： GIRAY GUENES ,  HUTHMACHER KLAUS ,  KLEEMANN AXEL ,  LIED THOMAS

IPC: A61K31/385 ,  C07C323/52 ,  A61P1/16 ,  A61P25/00 ,  C07C67/00 ,  C07C313/00 ,  C07C319/06 ,  C07C319/14 ,  C07C319/20 ,  C07C323/22 ,  C07C327/22 ,  C07D339/04 ,  C07D

Abstract: Compounds of forumla XII XII wherein R1 is hydrogen and R2 is phenyl or benzyl are useful as intermediates in the preparation of 1,2-dithiolane-3-pentanoic acid (D,L-thioctic acid) of formula IX IX

公开(公告)号：DE59702784D1

公开(公告)日：2001-01-25

申请号：DE59702784

申请日：1997-09-09

Applicant: DEGUSSA

Inventor： KRILL DR ,  GIRAY GUENES ,  HUTHMACHER DR ,  HUEBNER DR ,  TANNER DR

IPC: B01J23/02 ,  B01J23/75 ,  B01J23/755 ,  C07B61/00 ,  C07C45/67 ,  C07C45/82 ,  C07C45/83 ,  C07C49/603

公开(公告)号：DE19639569A1

公开(公告)日：1998-04-02

申请号：DE19639569

申请日：1996-09-26

Applicant: DEGUSSA

Inventor： KRILL STEFFEN DR ,  GIRAY GUENES ,  HUTHMACHER KLAUS DR ,  HUEBNER FRANK DR ,  TANNER HERBERT

IPC: B01J23/02 ,  B01J23/75 ,  B01J23/755 ,  C07B61/00 ,  C07C45/67 ,  C07C45/82 ,  C07C45/83 ,  C07C49/603

公开(公告)号：DD251750A5

公开(公告)日：1987-11-25

申请号：DD28894586

申请日：1986-04-09

Applicant: DEGUSSA

Inventor： GIRAY GUENES ,  HUTHMACHER KLAUS ,  KLEEMANN AXEL ,  LIED THOMAS

IPC: C07C323/52 ,  A61K31/385 ,  A61P1/16 ,  A61P25/00 ,  C07C67/00 ,  C07C313/00 ,  C07C319/06 ,  C07C319/14 ,  C07C319/20 ,  C07C323/22 ,  C07C327/22 ,  C07D339/04

Abstract: Compounds of forumla XII XII wherein R1 is hydrogen and R2 is phenyl or benzyl are useful as intermediates in the preparation of 1,2-dithiolane-3-pentanoic acid (D,L-thioctic acid) of formula IX IX

公开(公告)号：HUT40638A

公开(公告)日：1987-01-28

申请号：HU151686

申请日：1986-04-10

Applicant: DEGUSSA

Inventor： GIRAY GUENES ,  HUTHMACHER KLAUS ,  KLEEMANN AXEL ,  LIED THOMAS

IPC: A61K31/385 ,  A61P1/16 ,  C07C323/52 ,  A61P25/00 ,  C07C67/00 ,  C07C313/00 ,  C07C319/06 ,  C07C319/14 ,  C07C319/20 ,  C07C323/22 ,  C07C327/22 ,  C07D339/04 ,  C07C149/20

Abstract: Compounds of forumla XII XII wherein R1 is hydrogen and R2 is phenyl or benzyl are useful as intermediates in the preparation of 1,2-dithiolane-3-pentanoic acid (D,L-thioctic acid) of formula IX IX

公开(公告)号：DE3512911A1

公开(公告)日：1986-10-16

申请号：DE3512911

申请日：1985-04-11

Applicant: DEGUSSA

Inventor： GIRAY GUENES ,  HUTHMACHER KLAUS DR ,  KLEEMANN AXEL DR ,  LIED THOMAS DR

IPC: C07C323/52 ,  A61K31/385 ,  A61P1/16 ,  A61P25/00 ,  C07C67/00 ,  C07C313/00 ,  C07C319/06 ,  C07C319/14 ,  C07C319/20 ,  C07C323/22 ,  C07C327/22 ,  C07D339/04 ,  C07C149/20

Abstract: Compounds of forumla XII XII wherein R1 is hydrogen and R2 is phenyl or benzyl are useful as intermediates in the preparation of 1,2-dithiolane-3-pentanoic acid (D,L-thioctic acid) of formula IX IX