公开(公告)号：GB2363378A

公开(公告)日：2001-12-19

申请号：GB0120083

申请日：2000-02-24

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： POLIAKOFF MARTYN ,  GRAY WILLIAM KEITH ,  SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  WIELAND STEFAN

IPC: C07C1/24 ,  C07C41/09 ,  C07C41/56 ,  C07D307/08 ,  C07D317/12 ,  C07C1/20 ,  C07C41/50

Abstract: The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.

公开(公告)号：GB2363378B

公开(公告)日：2004-04-14

申请号：GB0120083

申请日：2000-02-24

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： POLIAKOFF MARTYN ,  GRAY WILLIAM KEITH ,  SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  WIELAND STEFAN

IPC: C07C1/24 ,  C07C41/09 ,  C07C41/56 ,  C07D307/08 ,  C07D317/12 ,  C07C1/20 ,  C07C41/50

Abstract: The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.

公开(公告)号：NO20014268L

公开(公告)日：2001-11-02

申请号：NO20014268

申请日：2001-09-03

Applicant: DEGUSSA

Inventor： POLIAKOFF MARTYN ,  ROSS STEPHEN KEITH ,  ROEDER STEFAN ,  GRAY WILLIAM KEITH ,  SWAN THOMAS MACKLYN ,  WIELAND STEFAN

IPC: C07C1/24 ,  C07C41/09 ,  C07C41/56 ,  C07D307/08 ,  C07D317/12 ,  C07C41/50

Abstract: The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.

公开(公告)号：NO20014268D0

公开(公告)日：2001-09-03

申请号：NO20014268

申请日：2001-09-03

Applicant: DEGUSSA

Inventor： POLIAKOFF MARTYN ,  ROSS STEPHEN KEITH ,  ROEDER STEFAN ,  GRAY WILLIAM KEITH ,  SWAN THOMAS MACKLYN ,  WIELAND STEFAN

IPC: C07C1/24 ,  C07C41/09 ,  C07C41/56 ,  C07D307/08 ,  C07D317/12 ,  C07C41/50

Abstract: The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.

公开(公告)号：NO20014268A

公开(公告)日：2001-11-02

申请号：NO20014268

申请日：2001-09-03

Applicant: DEGUSSA

Inventor： POLIAKOFF MARTYN ,  ROSS STEPHEN KEITH ,  ROEDER STEFAN ,  GRAY WILLIAM KEITH ,  SWAN THOMAS MACKLYN ,  WIELAND STEFAN

IPC: C07C1/24 ,  C07C41/09 ,  C07C41/56 ,  C07D307/08 ,  C07D317/12 ,  C07C41/50

CPC classification number: C07D317/12 ,  C07C1/24 ,  C07C41/09 ,  C07D307/08 ,  Y02P20/544 ,  C07C11/10 ,  C07C43/04 ,  C07C43/13 ,  C07C43/10