公开(公告)号：GB2363378B

公开(公告)日：2004-04-14

申请号：GB0120083

申请日：2000-02-24

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： POLIAKOFF MARTYN ,  GRAY WILLIAM KEITH ,  SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  WIELAND STEFAN

IPC: C07C1/24 ,  C07C41/09 ,  C07C41/56 ,  C07D307/08 ,  C07D317/12 ,  C07C1/20 ,  C07C41/50

Abstract: The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.

公开(公告)号：CA2336298A1

公开(公告)日：2000-01-13

申请号：CA2336298

申请日：1999-06-30

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： ROEDER STEFAN ,  ROSS STEPHEN KEITH ,  WIELAND STEFAN ,  MEEHAN NICOLA JANE ,  POLIAKOFF MARTYN

IPC: C07B61/00 ,  C07C45/50 ,  C07C47/02

Abstract: In a process for the hydroformylation of alkanes, alkenes or trialkylboranes under supercritical or near-critical conditions, hydroformylation is effecte d using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation may be achieved by independently varying one or more of the temperature, pressure, catalyst, mole ratios of hydrogen and carbon monoxide and flow rate.

公开(公告)号：CA2251693A1

公开(公告)日：1997-10-23

申请号：CA2251693

申请日：1997-04-11

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： SWAN THOMAS M ,  POLIAKOFF MARTYN ,  HITZLER MARTIN G ,  TACKE THOMAS ,  WIELAND STEFAN ,  ROSS STEPHEN K

IPC: B01J3/00 ,  C07B35/02 ,  C07B43/04 ,  C07B61/00 ,  C07C29/132 ,  C07C29/141 ,  C07C29/145 ,  C07C29/20 ,  C07C45/58 ,  C07C209/36 ,  C07D317/66 ,  C07C33/20 ,  C07C15/02 ,  C07C33/14 ,  C07C13/18 ,  C07C1/207 ,  C07C211/35 ,  C07C211/46

Abstract: A process for the selective hydrogenation of aliphatic or aromatic substrates under supercritical or near critical conditions. Hydrogenation is effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near critical reaction medium and selectively product formation is achieved by varying one or more of the temperature, pressure, catalyst and flow rate.

公开(公告)号：NO20014268L

公开(公告)日：2001-11-02

申请号：NO20014268

申请日：2001-09-03

Applicant: DEGUSSA

Inventor： POLIAKOFF MARTYN ,  ROSS STEPHEN KEITH ,  ROEDER STEFAN ,  GRAY WILLIAM KEITH ,  SWAN THOMAS MACKLYN ,  WIELAND STEFAN

IPC: C07C1/24 ,  C07C41/09 ,  C07C41/56 ,  C07D307/08 ,  C07D317/12 ,  C07C41/50

Abstract: The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.

公开(公告)号：AU729689B2

公开(公告)日：2001-02-08

申请号：AU4468797

申请日：1997-09-29

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  POLIAKOFF MARTYN ,  HITZLER MARTIN GEORG ,  SMAIL FIONA RUTH ,  TACKE THOMAS ,  WIELAND STEFAN

IPC: B01J31/06 ,  B01J3/00 ,  C07B37/02 ,  C07B37/04 ,  C07B41/06 ,  C07B61/00 ,  C07C2/66 ,  C07C2/70 ,  C07C2/86 ,  C07C15/02 ,  C07C41/30 ,  C07C43/205 ,  C07C45/46

Abstract: A process for the alkylation of aromatic substrates under supercritical or near-critical reaction conditions is described. In particular, a method for performing Friedel-Crafts alkylation reactions is disclosed under those conditions. Friedel-Crafts reactions may be effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation can be achieved by varying one or more of temperature, pressure, catalyst, flow rates and also by varying the ratios of aromatic substrate to alkylating agent.

公开(公告)号：GB2338956A

公开(公告)日：2000-01-12

申请号：GB9904603

申请日：1999-03-01

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： POLIAKOFF MARTYN ,  MEEHAN NICOLA JANE ,  ROSS STEPHEN KEITH ,  WIELAND STEFAN ,  ROEDER STEFAN

IPC: C07C45/50

公开(公告)号：NO991605L

公开(公告)日：1999-06-03

申请号：NO991605

申请日：1999-03-31

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  POLIAKOFF MARTYN ,  HITZLER MARTIN GEORG ,  SMAIL FIONA RUTH ,  TACKE THOMAS ,  WIELAND STEFAN

IPC: B01J3/00 ,  B01J31/06 ,  C07B37/02 ,  C07B37/04 ,  C07B41/06 ,  C07B61/00 ,  C07C2/66 ,  C07C2/70 ,  C07C2/86 ,  C07C15/02 ,  C07C41/30 ,  C07C43/205 ,  C07C45/46

Abstract: A process for the alkylation of aromatic substrates under supercritical or near-critical reaction conditions is described. In particular, a method for performing Friedel-Crafts alkylation reactions is disclosed under those conditions. Friedel-Crafts reactions may be effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation can be achieved by varying one or more of temperature, pressure, catalyst, flow rates and also by varying the ratios of aromatic substrate to alkylating agent.

公开(公告)号：NO991605A

公开(公告)日：1999-06-03

申请号：NO991605

申请日：1999-03-31

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  POLIAKOFF MARTYN ,  HITZLER MARTIN GEORG ,  SMAIL FIONA RUTH ,  TACKE THOMAS ,  WIELAND STEFAN

IPC: B01J31/06 ,  B01J3/00 ,  C07B37/02 ,  C07B37/04 ,  C07B41/06 ,  C07B61/00 ,  C07C2/66 ,  C07C2/70 ,  C07C2/86 ,  C07C15/02 ,  C07C41/30 ,  C07C43/205 ,  C07C45/46

CPC classification number: C07C45/46 ,  B01J3/008 ,  C07B37/02 ,  C07B37/04 ,  C07C2/66 ,  C07C2/864 ,  C07C41/30 ,  C07C2521/16 ,  C07C2529/04 ,  C07C2531/02 ,  C07C2531/08 ,  Y02P20/544 ,  C07C15/02 ,  C07C43/205

公开(公告)号：GB2326640A

公开(公告)日：1998-12-30

申请号：GB9817801

申请日：1997-04-11

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： POLIAKOFF MARTYN ,  SWAN THOMAS M ,  TACKE THOMAS ,  HITZLER MARTIN G ,  ROSS STEPHEN K ,  WIELAND STEFAN

IPC: B01J3/00 ,  C07B35/02 ,  C07B43/04 ,  C07B61/00 ,  C07C29/132 ,  C07C29/141 ,  C07C29/145 ,  C07C29/20 ,  C07C45/58 ,  C07C209/36 ,  C07D317/66

Abstract: PCT No. PCT/GB97/01014 Sec. 371 Date Feb. 18, 1999 Sec. 102(e) Date Feb. 18, 1999 PCT Filed Apr. 11, 1997 PCT Pub. No. WO97/38955 PCT Pub. Date Oct. 23, 1997Process for the selective hydrogenation of alphatic or aromatic substrates under supercritical or near critical conditions. Hydrogenation is effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near critical reaction medium and selectively of product formation is achieved by varying one or more of the temperature, pressure, catalyst and flow rate.

公开(公告)号：NO984844A

公开(公告)日：1998-12-17

申请号：NO984844

申请日：1998-10-16

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： POLIAKOFF MARTYN ,  SWAN THOMAS M ,  TACKE THOMAS ,  HITZLER MARTIN G ,  ROSS STEPHEN K ,  WIELAND STEFAN

IPC: B01J3/00 ,  C07B35/02 ,  C07B43/04 ,  C07B61/00 ,  C07C29/132 ,  C07C29/141 ,  C07C29/145 ,  C07C29/20 ,  C07C45/58 ,  C07C209/36 ,  C07D317/66

CPC classification number: C07C29/145 ,  B01J3/008 ,  C07B35/02 ,  C07B43/04 ,  C07C29/132 ,  C07C29/141 ,  C07C29/20 ,  C07C45/58 ,  C07C209/36 ,  C07C2601/14 ,  C07D317/66 ,  Y02P20/544 ,  C07C31/10 ,  C07C35/08 ,  C07C33/22 ,  C07C31/1355