公开(公告)号：GB2363378B

公开(公告)日：2004-04-14

申请号：GB0120083

申请日：2000-02-24

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： POLIAKOFF MARTYN ,  GRAY WILLIAM KEITH ,  SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  WIELAND STEFAN

IPC: C07C1/24 ,  C07C41/09 ,  C07C41/56 ,  C07D307/08 ,  C07D317/12 ,  C07C1/20 ,  C07C41/50

Abstract: The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.

公开(公告)号：GB2363378A

公开(公告)日：2001-12-19

申请号：GB0120083

申请日：2000-02-24

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： POLIAKOFF MARTYN ,  GRAY WILLIAM KEITH ,  SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  WIELAND STEFAN

IPC: C07C1/24 ,  C07C41/09 ,  C07C41/56 ,  C07D307/08 ,  C07D317/12 ,  C07C1/20 ,  C07C41/50

Abstract: The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.

公开(公告)号：GB2332905B

公开(公告)日：2000-08-23

申请号：GB9905939

申请日：1997-09-29

Applicant: THOMAS SWAN & COMPANY LIMITED ,  DEGUSSA

Inventor： SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  POLIAKOFF MARTYN ,  HITZLER MARTIN GEORG ,  SMAIL FIONA RUTH ,  TACKE THOMAS ,  WIELAND STEFAN

IPC: B01J3/00 ,  C07B37/02 ,  C07B37/04 ,  C07B41/06 ,  C07B61/00 ,  C07C2/66 ,  C07C2/70 ,  C07C2/86 ,  C07C15/02 ,  B01J31/06 ,  C07C41/30 ,  C07C43/205 ,  C07C45/46 ,  C07C37/14 ,  C07C37/16

Abstract: A process for the alkylation of aromatic substrates under supercritical or near-critical reaction conditions is described. In particular, a method for performing Friedel-Crafts alkylation reactions is disclosed under those conditions. Friedel-Crafts reactions may be effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation can be achieved by varying one or more of temperature, pressure, catalyst, flow rates and also by varying the ratios of aromatic substrate to alkylating agent.

公开(公告)号：ZA978764B

公开(公告)日：1998-03-27

申请号：ZA978764

申请日：1997-09-30

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： POLIAKOFF MARTYN ,  SWAN THOMAS MACKLYN ,  TACKE THOMAS ,  HITZLER MARTIN GEORG ,  ROSS STEPHEN KEITH ,  WIELAND STEFAN ,  SMAIL FIONA RUTH

IPC: B01J3/00 ,  C07B37/02 ,  B01J31/06 ,  C07B37/04 ,  C07B41/06 ,  C07B61/00 ,  C07C2/66 ,  C07C2/70 ,  C07C2/86 ,  C07C15/02 ,  C07C41/30 ,  C07C43/205 ,  C07C45/46 ,  C07B ,  B01J

Abstract: A process for the alkylation of aromatic substrates under supercritical or near-critical reaction conditions is described. In particular, a method for performing Friedel-Crafts alkylation reactions is disclosed under those conditions. Friedel-Crafts reactions may be effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation can be achieved by varying one or more of temperature, pressure, catalyst, flow rates and also by varying the ratios of aromatic substrate to alkylating agent.

公开(公告)号：NO20014268D0

公开(公告)日：2001-09-03

申请号：NO20014268

申请日：2001-09-03

Applicant: DEGUSSA

Inventor： POLIAKOFF MARTYN ,  ROSS STEPHEN KEITH ,  ROEDER STEFAN ,  GRAY WILLIAM KEITH ,  SWAN THOMAS MACKLYN ,  WIELAND STEFAN

IPC: C07C1/24 ,  C07C41/09 ,  C07C41/56 ,  C07D307/08 ,  C07D317/12 ,  C07C41/50

Abstract: The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.

公开(公告)号：NO991605D0

公开(公告)日：1999-03-31

申请号：NO991605

申请日：1999-03-31

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  POLIAKOFF MARTYN ,  HITZLER MARTIN GEORG ,  SMAIL FIONA RUTH ,  TACKE THOMAS ,  WIELAND STEFAN

IPC: B01J3/00 ,  B01J31/06 ,  C07B37/02 ,  C07B37/04 ,  C07B41/06 ,  C07B61/00 ,  C07C2/66 ,  C07C2/70 ,  C07C2/86 ,  C07C15/02 ,  C07C41/30 ,  C07C43/205 ,  C07C45/46 ,  C07B

Abstract: A process for the alkylation of aromatic substrates under supercritical or near-critical reaction conditions is described. In particular, a method for performing Friedel-Crafts alkylation reactions is disclosed under those conditions. Friedel-Crafts reactions may be effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation can be achieved by varying one or more of temperature, pressure, catalyst, flow rates and also by varying the ratios of aromatic substrate to alkylating agent.

公开(公告)号：NO20014268L

公开(公告)日：2001-11-02

申请号：NO20014268

申请日：2001-09-03

Applicant: DEGUSSA

Inventor： POLIAKOFF MARTYN ,  ROSS STEPHEN KEITH ,  ROEDER STEFAN ,  GRAY WILLIAM KEITH ,  SWAN THOMAS MACKLYN ,  WIELAND STEFAN

IPC: C07C1/24 ,  C07C41/09 ,  C07C41/56 ,  C07D307/08 ,  C07D317/12 ,  C07C41/50

Abstract: The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.

公开(公告)号：AU729689B2

公开(公告)日：2001-02-08

申请号：AU4468797

申请日：1997-09-29

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  POLIAKOFF MARTYN ,  HITZLER MARTIN GEORG ,  SMAIL FIONA RUTH ,  TACKE THOMAS ,  WIELAND STEFAN

IPC: B01J31/06 ,  B01J3/00 ,  C07B37/02 ,  C07B37/04 ,  C07B41/06 ,  C07B61/00 ,  C07C2/66 ,  C07C2/70 ,  C07C2/86 ,  C07C15/02 ,  C07C41/30 ,  C07C43/205 ,  C07C45/46

Abstract: A process for the alkylation of aromatic substrates under supercritical or near-critical reaction conditions is described. In particular, a method for performing Friedel-Crafts alkylation reactions is disclosed under those conditions. Friedel-Crafts reactions may be effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation can be achieved by varying one or more of temperature, pressure, catalyst, flow rates and also by varying the ratios of aromatic substrate to alkylating agent.

公开(公告)号：NO991605L

公开(公告)日：1999-06-03

申请号：NO991605

申请日：1999-03-31

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  POLIAKOFF MARTYN ,  HITZLER MARTIN GEORG ,  SMAIL FIONA RUTH ,  TACKE THOMAS ,  WIELAND STEFAN

IPC: B01J3/00 ,  B01J31/06 ,  C07B37/02 ,  C07B37/04 ,  C07B41/06 ,  C07B61/00 ,  C07C2/66 ,  C07C2/70 ,  C07C2/86 ,  C07C15/02 ,  C07C41/30 ,  C07C43/205 ,  C07C45/46

Abstract: A process for the alkylation of aromatic substrates under supercritical or near-critical reaction conditions is described. In particular, a method for performing Friedel-Crafts alkylation reactions is disclosed under those conditions. Friedel-Crafts reactions may be effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation can be achieved by varying one or more of temperature, pressure, catalyst, flow rates and also by varying the ratios of aromatic substrate to alkylating agent.

公开(公告)号：NO991605A

公开(公告)日：1999-06-03

申请号：NO991605

申请日：1999-03-31

Applicant: SWAN THOMAS & CO LTD ,  DEGUSSA

Inventor： SWAN THOMAS MACKLYN ,  ROSS STEPHEN KEITH ,  POLIAKOFF MARTYN ,  HITZLER MARTIN GEORG ,  SMAIL FIONA RUTH ,  TACKE THOMAS ,  WIELAND STEFAN

IPC: B01J31/06 ,  B01J3/00 ,  C07B37/02 ,  C07B37/04 ,  C07B41/06 ,  C07B61/00 ,  C07C2/66 ,  C07C2/70 ,  C07C2/86 ,  C07C15/02 ,  C07C41/30 ,  C07C43/205 ,  C07C45/46

CPC classification number: C07C45/46 ,  B01J3/008 ,  C07B37/02 ,  C07B37/04 ,  C07C2/66 ,  C07C2/864 ,  C07C41/30 ,  C07C2521/16 ,  C07C2529/04 ,  C07C2531/02 ,  C07C2531/08 ,  Y02P20/544 ,  C07C15/02 ,  C07C43/205