公开(公告)号：NZ333198A

公开(公告)日：2000-04-28

申请号：NZ33319898

申请日：1998-12-07

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMULLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF ,  THOMAS KLAUS-PETER

IPC: A61K8/21 ,  A61K8/25 ,  A61Q11/00 ,  A61K7/18 ,  A61K47/04 ,  A61K7/16

Abstract: Oral hygiene compositions, particularly toothpastes, comprise precipitated silica which contains an active substance in delayed release form. The active substance can contain fluoride ions.

公开(公告)号：AU665913B2

公开(公告)日：1996-01-18

申请号：AU6893294

申请日：1994-08-05

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMULLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF

IPC: A61K8/00 ,  A61K8/25 ,  A61Q11/00 ,  C01B33/193 ,  C01B33/187

Abstract: Precipitated silica having a BET surface area of 10-130 m /g, a CTAB surface area of 10-70 m /g, a mean particle diameter of 5-20 mu m, a Cu abrasion in 10% strength glycerol (glycerine) dispersion of 4-50 mg and a thickening behaviour in CMC solution (20% strength dispersion) of 300-3500 mPa.s is prepared by simultaneously adding alkali metal silicate (weight ratio SiO2: alkali metal oxide = 2.5-3.9:1) and a mineral acid to an initial charge of water which has been adjusted to a pH of from 7.0 to 9.9 or from 10.0 to 10.7 by addition of water, keeping the pH constant between 7.0 and 9.9 or 10.0 and 10.7, with the initial precipitation temperature being 50-90 DEG C and a viscosity increase commencing at the latest after 25% of the precipitation time, setting the pH to /= 160 g/l to 240 g/l, separating off the solid by filtration and washing, drying and milling it. The precipitated silica can be used as abrasive and/or thickening component in toothpastes.

公开(公告)号：NO942882L

公开(公告)日：1995-02-08

申请号：NO942882

申请日：1994-08-03

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMULLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF

IPC: A61K8/00 ,  A61K8/25 ,  A61Q11/00 ,  C01B33/193 ,  C01B33/18

Abstract: Precipitated silica having a BET surface area of 10-130 m /g, a CTAB surface area of 10-70 m /g, a mean particle diameter of 5-20 mu m, a Cu abrasion in 10% strength glycerol (glycerine) dispersion of 4-50 mg and a thickening behaviour in CMC solution (20% strength dispersion) of 300-3500 mPa.s is prepared by simultaneously adding alkali metal silicate (weight ratio SiO2: alkali metal oxide = 2.5-3.9:1) and a mineral acid to an initial charge of water which has been adjusted to a pH of from 7.0 to 9.9 or from 10.0 to 10.7 by addition of water, keeping the pH constant between 7.0 and 9.9 or 10.0 and 10.7, with the initial precipitation temperature being 50-90 DEG C and a viscosity increase commencing at the latest after 25% of the precipitation time, setting the pH to /= 160 g/l to 240 g/l, separating off the solid by filtration and washing, drying and milling it. The precipitated silica can be used as abrasive and/or thickening component in toothpastes.

公开(公告)号：IN179939B

公开(公告)日：1997-12-27

申请号：IN596CA1994

申请日：1994-07-26

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMULLER MATTHIAS ,  OTTO KAREN DR ,  RAUSCH RALF DR

IPC: C01B33/187

公开(公告)号：ES2092850T3

公开(公告)日：1996-12-01

申请号：ES94111686

申请日：1994-07-27

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMULLER MATTHIAS ,  OTTO KARIN DR ,  RAUSCH RALF DR

IPC: A61K8/00 ,  A61K8/25 ,  A61Q11/00 ,  C01B33/193

Abstract: Precipitated silica having a BET surface area of 10-130 m /g, a CTAB surface area of 10-70 m /g, a mean particle diameter of 5-20 mu m, a Cu abrasion in 10% strength glycerol (glycerine) dispersion of 4-50 mg and a thickening behaviour in CMC solution (20% strength dispersion) of 300-3500 mPa.s is prepared by simultaneously adding alkali metal silicate (weight ratio SiO2: alkali metal oxide = 2.5-3.9:1) and a mineral acid to an initial charge of water which has been adjusted to a pH of from 7.0 to 9.9 or from 10.0 to 10.7 by addition of water, keeping the pH constant between 7.0 and 9.9 or 10.0 and 10.7, with the initial precipitation temperature being 50-90 DEG C and a viscosity increase commencing at the latest after 25% of the precipitation time, setting the pH to /= 160 g/l to 240 g/l, separating off the solid by filtration and washing, drying and milling it. The precipitated silica can be used as abrasive and/or thickening component in toothpastes.

公开(公告)号：TR9802573A2

公开(公告)日：1999-06-21

申请号：TR9802573

申请日：1998-12-10

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMULLER MATTHIAS ,  OTTO DR KARIN ,  RAUSCH DR RALF ,  THOMAS KLAUS-PETER

IPC: A61K8/21 ,  A61K8/25 ,  A61Q11/00 ,  A61K7/18

CPC classification number: A61Q11/00 ,  A61K8/25

公开(公告)号：AU6893294A

公开(公告)日：1995-05-11

申请号：AU6893294

申请日：1994-08-05

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMULLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF

IPC: A61K8/00 ,  A61K8/25 ,  A61Q11/00 ,  C01B33/193 ,  C01B33/187

Abstract: Precipitated silica having a BET surface area of 10-130 m /g, a CTAB surface area of 10-70 m /g, a mean particle diameter of 5-20 mu m, a Cu abrasion in 10% strength glycerol (glycerine) dispersion of 4-50 mg and a thickening behaviour in CMC solution (20% strength dispersion) of 300-3500 mPa.s is prepared by simultaneously adding alkali metal silicate (weight ratio SiO2: alkali metal oxide = 2.5-3.9:1) and a mineral acid to an initial charge of water which has been adjusted to a pH of from 7.0 to 9.9 or from 10.0 to 10.7 by addition of water, keeping the pH constant between 7.0 and 9.9 or 10.0 and 10.7, with the initial precipitation temperature being 50-90 DEG C and a viscosity increase commencing at the latest after 25% of the precipitation time, setting the pH to /= 160 g/l to 240 g/l, separating off the solid by filtration and washing, drying and milling it. The precipitated silica can be used as abrasive and/or thickening component in toothpastes.

公开(公告)号：ES2060263T3

公开(公告)日：1994-11-16

申请号：ES91114887

申请日：1991-09-04

Applicant: DEGUSSA ,  CHEMICAL PHARMACEUTICAL RESEAR

Inventor： AGAIN IVAN PROF ,  BOYANOVA VERA PROF ,  OTTO KARIN DR ,  NEUMULLER MATTHIAS ,  DIPPMANN HARALD

IPC: A61K8/73 ,  A61Q11/00 ,  A61K7/16

Abstract: The preparation for the care of the teeth consists of the customary known ingredients of a preparation for the care of the teeth and contains as abrasive component cellulose powder in place of customary known polishing particles.

公开(公告)号：CA1182050A

公开(公告)日：1985-02-05

申请号：CA400805

申请日：1982-04-08

Applicant: DEGUSSA

Inventor： MULLER KARL-HANS ,  NEUMULLER MATTHIAS ,  TURK GUNTHER

IPC: A61K8/00 ,  A61K8/25 ,  A61K8/86 ,  A61Q11/00 ,  A61K7/16

Abstract: The present invention provides dentifrices having improved storage life with regard to rheology and abrasiveness and containing as cleaning agents for the first time bifunctional precipitated silicas (acting as thickeners and abrasives). These precipitated silicas are characterized by the following physicochemical characteristic data: Bowl mill Micronizer BET surface area sqm/g 15-110 15-110 Tamped powder density g/l 150-750 90-650 Secondary particle size distribution curve as determined by the Coulter counter Fig. 1 Fig. 2 "ALPINE" retained on sieve >63 .mu.m % by weight

公开(公告)号：TR199802573A2

公开(公告)日：1999-06-21

申请号：TR9802573

申请日：1998-12-10

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMULLER MATTHIAS ,  OTTO DR KARIN ,  RAUSCH DR RALF ,  THOMAS KLAUS-PETER

IPC: A61K8/21 ,  A61K8/25 ,  A61Q11/00 ,  A61K7/18

Abstract: A precipitated silica which contains an active substance with a characteristic, delayed release of active substance is prepared by adding the active substance during preparation of the precipitated silica. The precipitated silica containing the active substance may be added to oral hygiene agents such as toothpastes, topical fluoride preparations, dental materials or medicinal chewing gums.