公开(公告)号：JP2004115520A

公开(公告)日：2004-04-15

申请号：JP2003331956

申请日：2003-09-24

Applicant: Degussa Ag ,  デグサ アクチエンゲゼルシャフト

Inventor： ROSSEN KAI ,  LATINOVIC MILAN ,  SARICH MARTIN ,  GARDNER PETER ,  ROWELL SIMON

IPC: C07B61/00 ,  C07F5/02

CPC classification number: C07F5/025 ,  Y02P20/55

Abstract: PROBLEM TO BE SOLVED: To provide an improved method for producing 5-formyl-2-furylboric acid. SOLUTION: This method for producing the 5-formyl-2-furylboric acid comprises three steps composed of step (a) of adding a base to a composition composed of a boric ester and 2-furaldehyde whose formyl functional group is protected with a protective group, step (b) of subjecting the reaction mixture in step (a) to an acidic treatment, and step (c) of isolating 5-formyl-2-furylboric acid. COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2002199895A

公开(公告)日：2002-07-16

申请号：JP2001334859

申请日：2001-10-31

Applicant: DEGUSSA

Inventor： ROSSEN KAI ,  SARICH MARTIN ,  LATINOVIC MILAN ,  ROLLMANN CLAUDIA ,  BOMMARIUS ANDREAS

IPC: A61K31/198 ,  C12P7/44 ,  C12P13/04 ,  C12P13/20

Abstract: PROBLEM TO BE SOLVED: To obtain a compound useful for producing a bioactive substance, especially a medicine. SOLUTION: This enzymatic method for reductively aminating an α- ketodicarboxylic acid or its salt comprises, in an enzymatic method for reductively aminating the α-ketodicarboxylic acid represented by general formula I or its salt, carrying out the reductive amination using an amino acid dehydrogenase, especially phenylalanine dehydrogenase.

公开(公告)号：CA2557017A1

公开(公告)日：2005-10-13

申请号：CA2557017

申请日：2005-02-19

Applicant: DEGUSSA

Inventor： ROSSEN KAI ,  HOFFMANN ROLF ,  SARICH MARTIN

IPC: C07D207/24

Abstract: The present invention is concerned with a process for preparing compounds of the general formula (I). These compounds can preferably be used to prepare bioactive agents. The reaction of the invention starts from the corresponding hydroxy compounds which are oxidized, with Ru catalysis, in a one-phase aqueous system.

公开(公告)号：ES2252600T3

公开(公告)日：2006-05-16

申请号：ES03018657

申请日：2003-08-21

Applicant: DEGUSSA

Inventor： ROSSEN KAI DR ,  LATINOVIC MILAN ,  SARICH MARTIN ,  GARDNER PETER ,  ROWELL SIMON

IPC: C07B61/00 ,  C07F5/02

Abstract: Un método para producir ácido 5-formil-2-furilborónico, que comprende las etapas de: a) adición de una base a una composición que comprende un éster de ácido bórico y 2-furaldehído, en la quela funcionalidad formilo del 2-furaldehído está protegida con un grupo protector, y b) tratamiento ácido de la mezcla de reacción de la etapa a), y c) aislamiento del ácido 5-formil-2-furilborónico.

公开(公告)号：DE60302309D1

公开(公告)日：2005-12-22

申请号：DE60302309

申请日：2003-08-21

Applicant: DEGUSSA

Inventor： ROSSEN DR ,  LATINOVIC MILAN ,  SARICH MARTIN ,  GARDNER PETER ,  ROWELL SIMON

IPC: C07B61/00 ,  C07F5/02

Abstract: Preparation of 5-formyl-2-furyl boronic acid (I) involves addition of a base to a composition comprising boric acid ester (c1) and 2-furaldehyde (where formyl functionality is protected by a protective group) and, optionally, a solvent to obtain reaction mixture (a1); followed by acidic work up and isolation of (I).

公开(公告)号：DE10054492A1

公开(公告)日：2002-05-16

申请号：DE10054492

申请日：2000-11-03

Applicant: DEGUSSA

Inventor： ROSSEN KAI ,  SARICH MARTIN ,  LATINOVIC MILAN ,  ROLLMANN CLAUDIA ,  BOMMARIUS ANDREAS

IPC: A61K31/198 ,  C12P7/44 ,  C12P13/04 ,  C12P13/20 ,  C07B43/04 ,  C07C229/24 ,  C07C237/02 ,  C07D521/00 ,  C07F9/6564

Abstract: alpha -Ketodicarboxylic acid derivatives containing a tertiary carbon atom adjacent to the keto group are reductively aminated to the corresponding alpha -aminodicarboxylic acid derivatives using an amino acid dehydrogenase. The alpha -ketodicarboxylic acid derivatives are compounds of formula (I) and their salts: n = 1-3; R and R' = H; 1-8C alkyl; 1-8C alkoxy; 2-8C alkoxyalkyl; 6-18C aryl; 7-19C aralkyl; 3-18C heteroaryl; 4-19C heteroaralkyl; 1-8C alkyl-6-18C aryl; 1-8C alkyl-3-18C heteroaryl; 3-8C cycloalkyl; 1-8C alkyl-3-8C cycloalkyl; or 3-8C cycloalkyl-1-8C alkyl; or R and R' = a ring via 2-5C alkylene optionally containing 1 or more double bonds, optionally substituted with 1 or more 1-8C alkyl, 1-8C acyl, 1-8C alkoxy and 2-8C alkoxyalkyl and optionally containing hetero atoms, e.g. N, O, P and S R = OR, NHR (only in the description), or NRR'. Compounds are excluded when R and R' = H and are bonded to a C atom adjacent to the keto group and when: R or R' = 1-8C alkoxy; and R = NRR'.

公开(公告)号：DE502008001915D1

公开(公告)日：2011-01-13

申请号：DE502008001915

申请日：2008-02-07

Applicant: EVONIK DEGUSSA GMBH

Inventor： REICHERT DIETMAR ,  SARICH MARTIN ,  MERZ FRIEDHELM

IPC: C07D307/46

公开(公告)号：CA2620992A1

公开(公告)日：2008-08-16

申请号：CA2620992

申请日：2008-02-12

Applicant: EVONIK DEGUSSA GMBH

Inventor： REICHERT DIETMAR ,  SARICH MARTIN ,  MERZ FRIEDHELM

IPC: C07D307/46 ,  C07D307/48 ,  C07D307/50

Abstract: The present invention relates to a novel process for preparing 5-hydroxymethylfurfural of the formula II (see formula II) via a 5-acyloxymethylfurfural as an intermediate. The invention also relates to a novel process for preparing the 5-acyloxymethylfurfural intermediate.

公开(公告)号：CA2442252A1

公开(公告)日：2004-03-25

申请号：CA2442252

申请日：2003-09-23

Applicant: DEGUSSA

Inventor： ROWELL SIMON ,  SARICH MARTIN ,  GARDNER PETER ,  ROSSEN KAI ,  LATINOVIC MILAN

IPC: C07B61/00 ,  C07F5/02

Abstract: The present invention refers to an improved method of producing 5-formyl-2-furylboronic acid. The method is carried out in a three-step process comprising the steps of: a) addition of a base to a composition comprising a boric acid ester and 2-furaldehyde whereby the formyl functionality of the 2-furaldehyde is protected with a protective group, and b) acidic work-up of the reaction mixture of step a), and c) isolation of 5-formyl-2-furylboronic acid.

公开(公告)号：PT1720832E

公开(公告)日：2013-03-04

申请号：PT05707534

申请日：2005-02-19

Applicant: EVONIK DEGUSSA GMBH

Inventor： ROSSEN KAI ,  SARICH MARTIN ,  HOFFMANN ROLF

IPC: C07D207/24