公开(公告)号：AT361905T

公开(公告)日：2007-06-15

申请号：AT04803202

申请日：2004-11-20

Applicant: DEGUSSA

Inventor： HOFFMANN ROLF ,  KRAFT MICHAEL

IPC: C07B57/00 ,  C07C227/34 ,  C12P13/04

Abstract: The present invention is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallization with enantiomerically pure N-unprotected &bgr;-amino acid derivatives.

公开(公告)号：DE19912383A1

公开(公告)日：1999-09-30

申请号：DE19912383

申请日：1999-03-19

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ ,  HOFFMANN ROLF ,  PELGRIMS IVAN

IPC: C07D233/32 ,  C07D233/70 ,  C07D235/02 ,  C07D239/36 ,  C07D239/70 ,  C07D243/04 ,  C07D247/02

Abstract: Production of cyclic 4-oxoamidines (I) comprises oxidizing or dehydrogenating 1,3-diazacycloalkan-4-ones (II). Production of cyclic 4-oxoamidines of formula (I) or their salts comprises oxidizing or dehydrogenating 1,3-diazacycloalkan-4-ones of formula (II) or their salts: R , R = H; 1-8C alkyl, 2-8C alkenyl, 2-8C alkynyl, 1-8C alkoxy or 2-8C alkoxyalkyl, optionally substituted by halogen and/or N-, O- or P-containing groups; 3-7C (un)saturated cycloalkyl optionally substituted by 1-8C alkyl, 2-8C alkenyl, 1-8C alkoxy or 2-8C alkoxyalkyl, halogen and/or N-, O- or P-containing groups and optionally containing heteroatoms (e.g. N, O or P) in the ring; or aryl, aralkyl, heteroaryl or heteroaralkyl optionally substituted by 1-8C alkyl, 2-8C alkenyl, 1-8C alkoxy or 2-8C alkoxyalkyl, halogen and/or N-, O- or P-containing groups; or CR R is a 3- to 7-membered (un)saturated carbocyclic or heterocyclic ring optionally substituted by 1-8C alkyl, 2-8C alkenyl, 1-8C alkoxy or 2-8C alkoxyalkyl, halogen and/or N-, O- or P-containing groups; R -R = H; 1-8C alkyl, 2-8C alkenyl, 2-8C alkynyl, 1-8C alkoxy or 2-8C alkoxyalkyl, optionally substituted by halogen and/or N-, O- or P-containing groups; 3-7C (un)saturated cycloalkyl optionally substituted by 1-8C alkyl, 2-8C alkenyl, 1-8C alkoxy or 2-8C alkoxyalkyl, halogen and/or N-, O- or P-containing groups and optionally containing heteroatoms (e.g. N, O or P) in the ring; or aryl, aralkyl, heteroaryl or heteroaralkyl optionally substituted by 1-8C alkyl, 2-8C alkenyl, 1-8C alkoxy or 2-8C alkoxyalkyl, halogen and/or N-, O- or P-containing groups, provided that at least one of R and R is H; n = 1-3; bonds a, b = optional double bonds.

公开(公告)号：CA2547733C

公开(公告)日：2009-09-08

申请号：CA2547733

申请日：2004-11-20

Applicant: DEGUSSA

Inventor： HOFFMANN ROLF ,  KRAFT MICHAEL

IPC: C07B57/00 ,  C07C227/34 ,  C12P13/04

Abstract: The present invention relates to a process for the resolution of derivatives of alpha-amino acids. In particular the process is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallisation with enantiomerically pure N-unprotected beta-amino aci d derivatives.

公开(公告)号：DE102004010943A1

公开(公告)日：2005-09-29

申请号：DE102004010943

申请日：2004-03-03

Applicant: DEGUSSA

Inventor： ROSSEN KAI ,  HOFFMANN ROLF ,  SARICH MARTIN

IPC: C07D207/24

Abstract: The present invention is concerned with a process for preparing compounds of the general formula (I). These compounds can preferably be used to prepare bioactive agents. The reaction of the invention starts from the corresponding hydroxy compounds which are oxidized, with Ru catalysis, in a one-phase aqueous system.

公开(公告)号：DE602004006438T2

公开(公告)日：2008-01-10

申请号：DE602004006438

申请日：2004-11-20

Applicant: EVONIK DEGUSSA GMBH

Inventor： HOFFMANN ROLF ,  KRAFT MICHAEL

IPC: C07B57/00 ,  C07C227/34 ,  C12P13/04

Abstract: The present invention is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallization with enantiomerically pure N-unprotected &bgr;-amino acid derivatives.

公开(公告)号：CA2557017A1

公开(公告)日：2005-10-13

申请号：CA2557017

申请日：2005-02-19

Applicant: DEGUSSA

Inventor： ROSSEN KAI ,  HOFFMANN ROLF ,  SARICH MARTIN

IPC: C07D207/24

Abstract: The present invention is concerned with a process for preparing compounds of the general formula (I). These compounds can preferably be used to prepare bioactive agents. The reaction of the invention starts from the corresponding hydroxy compounds which are oxidized, with Ru catalysis, in a one-phase aqueous system.

公开(公告)号：CA2547733A1

公开(公告)日：2005-06-30

申请号：CA2547733

申请日：2004-11-20

Applicant: DEGUSSA

Inventor： HOFFMANN ROLF ,  KRAFT MICHAEL

IPC: C07B57/00 ,  C07C227/34 ,  C12P13/04

Abstract: The present invention relates to a process for the resolution of derivatives of alpha-amino acids. In particular the process is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallisation with enantiomerically pure N-unprotected beta-amino aci d derivatives.

公开(公告)号：PT1720832E

公开(公告)日：2013-03-04

申请号：PT05707534

申请日：2005-02-19

Applicant: EVONIK DEGUSSA GMBH

Inventor： ROSSEN KAI ,  SARICH MARTIN ,  HOFFMANN ROLF

IPC: C07D207/24

公开(公告)号：CA2557017C

公开(公告)日：2012-10-02

申请号：CA2557017

申请日：2005-02-19

Applicant: DEGUSSA

Inventor： ROSSEN KAI ,  HOFFMANN ROLF ,  SARICH MARTIN

IPC: C07D207/24

Abstract: The present invention is concerned with a process for preparing compounds of the general formula (I). These compounds can preferably be used to prepare bioactive agents. The reaction of the invention starts from the corresponding hydroxy compounds which are oxidized, with Ru catalysis, in a one-phase aqueous system.

公开(公告)号：DK1692084T3

公开(公告)日：2007-09-03

申请号：DK04803202

申请日：2004-11-20

Applicant: DEGUSSA

Inventor： HOFFMANN ROLF ,  KRAFT MICHAEL

IPC: C07B57/00 ,  C07C227/34 ,  C12P13/04

Abstract: The present invention is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallization with enantiomerically pure N-unprotected &bgr;-amino acid derivatives.