公开(公告)号：JPH1171394A

公开(公告)日：1999-03-16

申请号：JP17487698

申请日：1998-06-22

Applicant: DEGUSSA

Inventor： TANNER HERBERT ,  DRAUZ KARLHEINZ ,  STINGL KLAUS DR ,  SATOR GERHARD DR ,  BETHGE HORST ,  MOELLER ROLAND ,  TACKE THOMAS DR ,  REHREN CLAUS DR

IPC: C07K1/36 ,  C07K5/02 ,  C07K5/068

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound useful as an intermediate or the like for producing a blood pressure regulator by posttreating a crude substance from a production process for a specific N-substituted-L-lysyl-L-proline with liquid or supercritical CO2 . SOLUTION: A crude substance from a production process for a 1-[N2-((S)- ethoxycarbonyl)-3-phenylpropyl)-N6-trifluoroacetyl]-L-lysyl-L-proline (LPE) in which the LPE is enriched and present is precharged into an extraction container C and supercritical CO2 or liquid CO2 prepared by making liquid CO2 flow from a collection container D to a pump P1 , compressing the liquid CO2 to an extraction pressure and heating the compressed liquid CO2 to an extraction temperature with a heat exchanger E1 is fed to the extraction container C to dissolve an extractible substance in the CO2 during the passage thereof through the extraction container C. The CO2 loaded with the dissolved substance is then led to a separator S and the pressure or temperature or both are changed to deposit the extracted substance. Thereby, the LPE which is an intermediate for an inhibitor of angiotensin converting enzymes effectively useful as a blood pressure regulator is obtained in a short time.

公开(公告)号：DE19827309A1

公开(公告)日：1998-12-24

申请号：DE19827309

申请日：1998-06-19

Applicant: DEGUSSA

Inventor： TANNER HERBERT DR ,  DRAUZ KARLHEINZ PROF DR ,  STINGL KLAUS DR ,  SATOR GERHARD DR ,  BETHGE HORST ,  MOELLER ROLAND ,  TACKE THOMAS DR ,  REHREN CLAUS DR

IPC: C07K1/36 ,  C07K5/02 ,  C07K5/068 ,  A61K38/05

Abstract: A method for working up lisinopril (Tfa) ethyl ester (LPE), i.e. 1-N2-((S)-ethoxycarbonyl)-3-phenylpropyl)-N6-trifluoroacetyl-L-lysyl-L -proline of formula (I), involves treating crude LPE from a synthesis process, as a mixture enriched in LPE, with liquid or supercritical carbon dioxide.