公开(公告)号：RO76053A

公开(公告)日：1981-11-04

申请号：RO9851779

申请日：1979-09-06

Applicant: DEGUSSA

Inventor： KLINGER KARL H ,  KLEEMANN AXEL ,  STREMANN FRITZ ,  THIEMER KLAUS

IPC: A61K31/403 ,  A61K31/155 ,  A61K31/405 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  C07C133/10

Abstract: Compounds corresponding to the formula I are disclosed, wherein Alk represents a C2-C5-alkylene groups optionally substituted by a hydroxy group and Ar represent an optionally substituted phenyl, naphthyl, tetrahydronaphthyl, indanyl or indenyl radical or a monocyclic or condensed bicyclic or tricyclic heterocyclic radical which is optionally substituted, the heterocyclic radical consisting of individual rings having 5 or 6 members and optionally containing from 1 to 4 hetero atoms, and the acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyl guanidines block the beta -receptors of the adrenergic nerve system, and also reduce blood pressure.