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公开(公告)号：WO9963972A9
公开(公告)日：2000-10-12
申请号：PCT/US9912772
申请日：1999-06-08
Applicant: DELSYS PHARMACEUTICAL CORP , CHEN JEN CHI , CHRAI SUGGY S , DESAI NITIN VITHALBHAI , HAMMER LAWRENCE HARRISON , KELLER DAVID , KUMAR NALIN , LAL PRINCE , LEVINE AARON WILLIAM , MURARI RAMASWAMY , MARA KERRY DENNIS O , POLINIAK EUGENE SAMUEL , RIVENBURG HOWARD CHRISTOPHER , ROACH WILLIAM RONALD , ROSATI DOMINIC STEPHEN , SINGH BAWA , SOUTHGATE PETER DAVID , SUN HOI CHEONG , ZANZUCCHI PETER JOHN
Inventor： CHEN JEN-CHI , CHRAI SUGGY S , DESAI NITIN VITHALBHAI , HAMMER LAWRENCE HARRISON , KELLER DAVID , KUMAR NALIN , LAL PRINCE , LEVINE AARON WILLIAM , MURARI RAMASWAMY , O'MARA KERRY DENNIS , POLINIAK EUGENE SAMUEL , RIVENBURG HOWARD CHRISTOPHER , ROACH WILLIAM RONALD , ROSATI DOMINIC STEPHEN , SINGH BAWA , SOUTHGATE PETER DAVID , SUN HOI CHEONG , ZANZUCCHI PETER JOHN
IPC: A61K9/14 , A61J1/03 , A61J3/00 , A61K9/16 , A61K9/51 , A61K9/70 , B05B5/025 , B05B5/08 , B05B5/16 , B65B1/04 , B65B1/30 , B65B11/50
CPC classification number: A61K9/70 , A61J1/035 , A61J3/00 , B05B5/08 , B65B1/04 , B65B1/30 , B65B11/50
Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.
Abstract translation: 本发明提供了一种产品（1），其包括药物单位剂量或诊断形式（6），其包含至少一种活性成分，其有效量不超过预定目标量的约5％ 。 在一个实施例中，单元形式包括衬底（8），设置在衬底上的沉积物（14）和覆盖在沉积物上的覆盖层（9），并且通过围绕该沉积物的键与衬底接合， 从而将其封装在基板和盖基板之间。 沉积物包含粉末，其中至少一些包括至少一种活性成分。 单元形式通过干粉沉积设备产生，其使用静电卡盘和带电粉末输送装置将粉末静电沉积在基底上。
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公开(公告)号：WO0203914A3
公开(公告)日：2002-06-06
申请号：PCT/US0121422
申请日：2001-07-06
Applicant: DELSYS PHARMACEUTICAL CORP , MURARI RAMASWAMY , CHRAI SUGGY S
Inventor： MURARI RAMASWAMY , CHRAI SUGGY S
IPC: A61K9/14 , A61K9/20 , A61K9/48 , A61K9/58 , A61K9/70 , A61K31/198 , A61K38/23 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61P5/14 , A61K31/195
CPC classification number: A61K9/2095 , A61K9/2086 , A61K31/198
Abstract: A method is disclosed for formulating a solid dosage of thyroid hormone, while avoiding instability caused by interaction of the active ingredient with excipients. The thyroid hormone may be levothyroxine sodium or triiodothyronine. The method comprises depositing the active ingredient, preferably electrostatically, as a dry powder substantially free of excipients, onto a pharmaceutically acceptable polymer substrate. Solid pharmaceutical dosage forms also are disclosed.
Abstract translation: 公开了一种配制固体剂量的甲状腺激素，同时避免由活性成分与赋形剂相互作用引起的不稳定性的方法。 甲状腺激素可能是左旋甲状腺素钠或三碘甲状腺氨酸。 该方法包括将活性成分（优选静电地）以基本上不含赋形剂的干粉形式沉积到药学上可接受的聚合物基质上。 也公开了固体药物剂型。
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公开(公告)号：WO0213762A3
公开(公告)日：2002-05-16
申请号：PCT/US0124949
申请日：2001-08-09
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： MURARI RAMASWAMY , CHRAI SUGGY S , CHEN JEN-CHI , KATDARE ASHOK , PARRY GREGORY E , KARETNY MARC S
IPC: A61K9/20 , A61K9/70 , A61K47/32 , A61K47/34 , A61K47/38 , A01N25/08 , A01N25/34 , A61K9/00 , A61K9/14 , A61K9/46 , A61K9/50 , B65D73/00 , B65D85/42
CPC classification number: A61K9/2086 , A61K9/2095 , A61K9/7007
Abstract: A novel solid pharmaceutical dosage formulation of hydrophobic drugs is disclosed, which provides enhanced dissolution and improved bioavailability. The hydrophobic drug is deposited electrostatically on the base substrate. The dosage form may include any pharmaceutically acceptable additive, disposed within a carrier that is segregated from, but in contact with, the deposit. Figure No. 1 depicts an isometric view of a product comprising a strip package containing a plurality of unit forms in accordance with the prior art.
Abstract translation: 公开了一种新型的疏水药物的固体药物剂型，其提供增强的溶解和改善的生物利用度。 疏水药物静电沉积在基底上。 剂型可以包括任何药学上可接受的添加剂，其被放置在与沉积物隔离但与沉积物接触的载体内。 图1示出了包括根据现有技术的包含多个单元形式的带状包装的产品的等距视图。
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公开(公告)号：WO0018370A3
公开(公告)日：2000-07-20
申请号：PCT/US9921752
申请日：1999-09-22
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHRAI SUGGY S , MURARI RAMASWAMY
IPC: A61J3/00 , A61K9/00 , A61K9/08 , A61K9/20 , A61K45/00 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K9/10
CPC classification number: A61K9/2086 , A61K9/0056
Abstract: A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.
Abstract translation: 一种用于口服递送的液体药物，其中在使用时将固体单位剂型加入到液体中，其中单位剂型由可溶于液体的底物和药学有效量的颗粒状药物活性物质组成。 在使用时，将单位剂型添加到液体中，而不需要测量液体，并且消耗整个液体以提供药学有效量的材料的口服递送。
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公开(公告)号：EP1307097A4
公开(公告)日：2004-01-28
申请号：EP01963853
申请日：2001-08-09
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： MURARI RAMASWAMY , CHRAI SUGGY S , CHEN JEN-CHI , KATDARE ASHOK , PARRY GREGORY E , KARETNY MARC S
CPC classification number: A61K9/2086 , A61K9/2095 , A61K9/7007
Abstract: A novel solid pharmaceutical dosage formulation of hydrophobic drugs is disclosed, which provides enhanced dissolution and improved bioavailability. The hydrophobic drug is deposited electrostatically on the base substrate. The dosage form may include any pharmaceutically acceptable additive, disposed within a carrier that is segregated from, but in contact with, the deposit. Figure No. 1 depicts an isometric view of a product comprising a strip package containing a plurality of unit forms in accordance with the prior art.
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Patent Agency Ranking
公开(公告)号：EP1248595A4
公开(公告)日：2006-06-14
申请号：EP01904967
申请日：2001-01-22
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： KUPPERPBLATT GARY B , KARETNY MARC S , MURARI RAMASWAMY , CHRAI SUGGY S
IPC: A61K9/00 , A61K9/22 , A61K9/24 , A61K9/48 , A61K31/403 , A61K31/522 , A61P1/04 , A61P1/08 , A61P11/00 , A61P11/06 , A61P11/08 , A61P25/00 , A61P25/06 , A61K9/14 , A61K9/20
CPC classification number: A61K9/4808 , A61K9/209
Abstract: Controlled release, multi-step drug dosage forms comprising a plurality of dose units and a plurality of separators that control release of drug from the dose units. In one embodiment, a dose unit is a single dosage amount of a drug that is electrostatically deposited onto a substrate. The dosage forms are designed to deliver a drug to exhibit a desired pharmacokinetic profile.
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公开(公告)号：HU0303561A2
公开(公告)日：2004-03-29
申请号：HU0303561
申请日：2001-06-22
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHRAI SUGGY S , MURARI RAMASWAMY , PAWLO GEORGE R , SANTONASTASO GARY
Abstract: A dispenser for storing/dispensing pharmaceutical dosages that are provided in a stamplike (flat) dosage form. In some embodiments, the present dispenser includes a housing for retaining a plurality of stacked, individual "stamp-like" pharmaceutical dosages. Disposed within the housing beneath the dosages is a bias element, such as a helical spring, that urges the dosages towards a dosage delivery port of the housing. From the dosage delivery port, dosages are dispensed through an aperture. In other embodiments, the instant dispenser includes a cylindrical main body for retaining pharmaceutical dosages having a stamp-like dosage form that are collectively organized in a roll. A dosage delivery port depending from the cylindrical main body receives dosages one at a time therefrom. The present dispenser is configured, in various embodiments, for manual, mechanically assisted, or automated dispensing. Moreover, the present dispenser includes, when appropriately automated, control electronics that (1) alert a user of a scheduled dosage, and/or (2) dispense a dosage at a prescribed time or at a prescribed time interval, and/or (3) maintain a dosage record.
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公开(公告)号：AU7323101A
公开(公告)日：2002-01-21
申请号：AU7323101
申请日：2001-07-06
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： MURARI RAMASWAMY , KATDARE ASHOK , CHRAI SUGGY S , HARMON TROY M
IPC: A61K9/14 , A61K9/16 , A61K9/20 , A61K9/28 , A61K9/48 , A61K31/198 , A61K31/4178 , A61K47/30 , A61K47/32 , A61K47/38 , A61K47/42 , A61L2/00 , B05D1/04
Abstract: A method is disclosed for formulating healthcare products, including solid pharmaceutical compositions, while avoiding instability caused ba interaction of the active ingredient with excipients. The method comprises the steps of: (a) selecting an active ingredient that loses stability or potency upon interaction with pharmaceutical excipients; and (b) depositing the active ingredient, preferably electrostatically, as a dry powder substantially free of excipients, onto a pharmaceutically acceptable polymer substrate.
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公开(公告)号：CA2413015A1
公开(公告)日：2002-01-17
申请号：CA2413015
申请日：2001-07-11
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： KELLER DAVID , MURARI RAMASWAMY , PAWLO GEORGE R , SANTONASTOSO GARY , CHRAI SUGGY S
Abstract: Provided is a re-circulating particle feed apparatus (10) comprising: a circular conduit (11) suitable for circulating gas suspended particulates; a deposition station (17) comprising an opening onto the conduit into which an electrostatic chuck fits, with a deposition surface of the chuck (9) fits, a nd a propulsion device (12) for maintaining gas and particle circulation throug h the conduit (11), wherein the device (12) is adapted to maintain circulation at a rate that brings a deposition effective amount of particles within a range of electro-attractive influence at the deposition station (17).
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公开(公告)号：HU0301611A2
公开(公告)日：2003-08-28
申请号：HU0301611
申请日：2001-07-11
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHEN JEN-CHI , CHRAI SUGGY S , MURARI RAMASWAMY
Abstract: Provided is, among other things, a conductive inlay film comprising; a layer of dielectric film (21) having a pattern of holes (23) suitable to define selected regions to which particles will be deposited by electrostatic deposition; and a conductive element (22) comprising polymer, which element comprises (a) a conductive film laminated (22) against the dielectric film (21) or (b) a conductive film embedded within the holes (23), the portion of the conductive element appearing within the holes comprising conductive inlays, wherein the conductive element (22) is adapted to contact one or more electrode pads and provide electrical potential at the selected regions, and wherein the dielectric film (21) electrically isolates the selected regions.
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