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公开(公告)号：WO9963972A9
公开(公告)日：2000-10-12
申请号：PCT/US9912772
申请日：1999-06-08
Applicant: DELSYS PHARMACEUTICAL CORP , CHEN JEN CHI , CHRAI SUGGY S , DESAI NITIN VITHALBHAI , HAMMER LAWRENCE HARRISON , KELLER DAVID , KUMAR NALIN , LAL PRINCE , LEVINE AARON WILLIAM , MURARI RAMASWAMY , MARA KERRY DENNIS O , POLINIAK EUGENE SAMUEL , RIVENBURG HOWARD CHRISTOPHER , ROACH WILLIAM RONALD , ROSATI DOMINIC STEPHEN , SINGH BAWA , SOUTHGATE PETER DAVID , SUN HOI CHEONG , ZANZUCCHI PETER JOHN
Inventor： CHEN JEN-CHI , CHRAI SUGGY S , DESAI NITIN VITHALBHAI , HAMMER LAWRENCE HARRISON , KELLER DAVID , KUMAR NALIN , LAL PRINCE , LEVINE AARON WILLIAM , MURARI RAMASWAMY , O'MARA KERRY DENNIS , POLINIAK EUGENE SAMUEL , RIVENBURG HOWARD CHRISTOPHER , ROACH WILLIAM RONALD , ROSATI DOMINIC STEPHEN , SINGH BAWA , SOUTHGATE PETER DAVID , SUN HOI CHEONG , ZANZUCCHI PETER JOHN
IPC: A61K9/14 , A61J1/03 , A61J3/00 , A61K9/16 , A61K9/51 , A61K9/70 , B05B5/025 , B05B5/08 , B05B5/16 , B65B1/04 , B65B1/30 , B65B11/50
CPC classification number: A61K9/70 , A61J1/035 , A61J3/00 , B05B5/08 , B65B1/04 , B65B1/30 , B65B11/50
Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.
Abstract translation: 本发明提供了一种产品（1），其包括药物单位剂量或诊断形式（6），其包含至少一种活性成分，其有效量不超过预定目标量的约5％ 。 在一个实施例中，单元形式包括衬底（8），设置在衬底上的沉积物（14）和覆盖在沉积物上的覆盖层（9），并且通过围绕该沉积物的键与衬底接合， 从而将其封装在基板和盖基板之间。 沉积物包含粉末，其中至少一些包括至少一种活性成分。 单元形式通过干粉沉积设备产生，其使用静电卡盘和带电粉末输送装置将粉末静电沉积在基底上。
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公开(公告)号：WO0213762A3
公开(公告)日：2002-05-16
申请号：PCT/US0124949
申请日：2001-08-09
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： MURARI RAMASWAMY , CHRAI SUGGY S , CHEN JEN-CHI , KATDARE ASHOK , PARRY GREGORY E , KARETNY MARC S
IPC: A61K9/20 , A61K9/70 , A61K47/32 , A61K47/34 , A61K47/38 , A01N25/08 , A01N25/34 , A61K9/00 , A61K9/14 , A61K9/46 , A61K9/50 , B65D73/00 , B65D85/42
CPC classification number: A61K9/2086 , A61K9/2095 , A61K9/7007
Abstract: A novel solid pharmaceutical dosage formulation of hydrophobic drugs is disclosed, which provides enhanced dissolution and improved bioavailability. The hydrophobic drug is deposited electrostatically on the base substrate. The dosage form may include any pharmaceutically acceptable additive, disposed within a carrier that is segregated from, but in contact with, the deposit. Figure No. 1 depicts an isometric view of a product comprising a strip package containing a plurality of unit forms in accordance with the prior art.
Abstract translation: 公开了一种新型的疏水药物的固体药物剂型，其提供增强的溶解和改善的生物利用度。 疏水药物静电沉积在基底上。 剂型可以包括任何药学上可接受的添加剂，其被放置在与沉积物隔离但与沉积物接触的载体内。 图1示出了包括根据现有技术的包含多个单元形式的带状包装的产品的等距视图。
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公开(公告)号：EP1307097A4
公开(公告)日：2004-01-28
申请号：EP01963853
申请日：2001-08-09
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： MURARI RAMASWAMY , CHRAI SUGGY S , CHEN JEN-CHI , KATDARE ASHOK , PARRY GREGORY E , KARETNY MARC S
CPC classification number: A61K9/2086 , A61K9/2095 , A61K9/7007
Abstract: A novel solid pharmaceutical dosage formulation of hydrophobic drugs is disclosed, which provides enhanced dissolution and improved bioavailability. The hydrophobic drug is deposited electrostatically on the base substrate. The dosage form may include any pharmaceutically acceptable additive, disposed within a carrier that is segregated from, but in contact with, the deposit. Figure No. 1 depicts an isometric view of a product comprising a strip package containing a plurality of unit forms in accordance with the prior art.
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公开(公告)号：CA2413549A1
公开(公告)日：2002-01-17
申请号：CA2413549
申请日：2001-07-11
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： MURARI RAMASWAMY , CHEN JEN-CHI , CHRAI SUGGY S
IPC: G01N33/15 , A61J3/00 , A61K9/70 , A61M15/00 , A61M15/02 , B05C13/00 , B32B3/24 , B05B5/00 , B05D1/32
Abstract: Provided is, among other things, a conductive inlay film comprising; a layer of dielectric film (21) having a pattern of holes (23) suitable to define selected regions to which particles will be deposited by electrostatic deposition; and a conductive element (22) comprising polymer, which element comprises (a) a conductive film laminated (22) against the dielectric film (21) or (b) a conductive film embedded within the holes (23), the portion of the conductive element appearing within the holes comprising conductive inlays, wherein the conductive element (22) is adapted to contact one or mor e electrode pads and provide electrical potential at the selected regions, and wherein the dielectric film (21) electrically isolates the selected regions.
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公开(公告)号：HU0102753A2
公开(公告)日：2001-11-28
申请号：HU0102753
申请日：1999-06-08
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHEN JEN-CHI , CHRAI SUGGY S , DESAI NITIN VITHALBHAI , HAMMER LAWRENCE HARRISON , KELLER DAVID , KUMAR NALIN , LAL PRINCE , LEVINE AARON WILLIAM , MURARI RAMASWAMY , O'MARA KERRY DENNIS , POLINIAK EUGENE SAMUEL , RIVENBURG HOWARD CHRISTOPHER , ROACH WILLIAM RONALD , ROSATI DOMINIC STEPHEN , SINGH BAWA , SOUTHGATE PETER DAVID , SUN HOI CHEONG , ZANZUCCHI PETER JOHN
IPC: A61K9/14 , A61J1/03 , A61J3/00 , A61K9/16 , A61K9/51 , A61K9/70 , B05B5/025 , B05B5/08 , B05B5/16 , B65B1/04 , B65B1/30 , B65B11/50
Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.
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Patent Agency Ranking
公开(公告)号：HU0301611A2
公开(公告)日：2003-08-28
申请号：HU0301611
申请日：2001-07-11
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHEN JEN-CHI , CHRAI SUGGY S , MURARI RAMASWAMY
Abstract: Provided is, among other things, a conductive inlay film comprising; a layer of dielectric film (21) having a pattern of holes (23) suitable to define selected regions to which particles will be deposited by electrostatic deposition; and a conductive element (22) comprising polymer, which element comprises (a) a conductive film laminated (22) against the dielectric film (21) or (b) a conductive film embedded within the holes (23), the portion of the conductive element appearing within the holes comprising conductive inlays, wherein the conductive element (22) is adapted to contact one or more electrode pads and provide electrical potential at the selected regions, and wherein the dielectric film (21) electrically isolates the selected regions.
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公开(公告)号：AU763869B2
公开(公告)日：2003-07-31
申请号：AU4675599
申请日：1999-06-08
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHEN JEN-CHI , CHRAI SUGGY S , DESAI NITIN VITHALBHAI , HAMMER LAWRENCE HARRISON , KELLER DAVID , KUMAR NALIN , LAL PRINCE , LEVINE AARON WILLIAM , MURARI RAMASWAMY , O'MARA KERRY DENNIS , POLINIAK EUGENE SAMUEL , RIVENBURG HOWARD CHRISTOPHER , ROACH WILLIAM RONALD , ROSATI DOMINIC STEPHEN , SINGH BAWA , SOUTHGATE PETER DAVID , SUN HOI CHEONG , ZANZUCCHI PETER JOHN
IPC: A61K9/14 , A61J1/03 , A61J3/00 , A61K9/16 , A61K9/51 , A61K9/70 , B05B5/025 , B05B5/08 , B05B5/16 , B65B1/04 , B65B1/30 , B65B11/50
Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.
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公开(公告)号：AU8477201A
公开(公告)日：2002-02-25
申请号：AU8477201
申请日：2001-08-09
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： MURARI RAMASWAMY , CHRAI SUGGY S , CHEN JEN-CHI , KATDARE ASHOK , PARRY GREGORY E , KARETNY MARC S
Abstract: A novel solid pharmaceutical dosage formulation of hydrophobic drugs is disclosed, which provides enhanced dissolution and improved bioavailability. The formulation comprises: a base substrate comprising a first polymer; a deposit, comprising a therapeutic amount of a hydrophobic drug, deposited on the base substrate; a cover substrate comprising a second polymer, the cover substrate covering the deposit and joined to the base substrate by a bond that encircles the deposit; and a dissolution-enhancing amount of a surfactant, disposed within a carrier that is segregated from, but in contact with, the deposit. In another embodiment, the dosage form may include any pharmaceutically acceptable additive, disposed within a carrier that is segregated from, but in contact with, the deposit. In a preferred embodiment, the hydrophobic drug is deposited electrostatically on the base substrate.
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公开(公告)号：CA2417813A1
公开(公告)日：2002-02-21
申请号：CA2417813
申请日：2001-08-09
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： KARETNY MARC S , MURARI RAMASWAMY , PARRY GREGORY E , CHRAI SUGGY S , CHEN JEN-CHI , KATDARE ASHOK
IPC: A61K9/20 , A61K9/70 , A61K47/32 , A61K47/34 , A61K47/38 , A01N25/08 , B65D73/00 , A61K9/00 , A61K9/14 , A01N25/34 , B65D85/42 , A61K9/46 , A61K9/50
Abstract: A novel solid pharmaceutical dosage formulation of hydrophobic drugs is disclosed, which provides enhanced dissolution and improved bioavailability. The hydrophobic drug is deposited electrostatically on the base substrate. T he dosage form may include any pharmaceutically acceptable additive, disposed within a carrier that is segregated from, but in contact with, the deposit. Figure No. 1 depicts an isometric view of a product comprising a strip packa ge containing a plurality of unit forms in accordance with the prior art.
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公开(公告)号：AU7726801A
公开(公告)日：2002-01-21
申请号：AU7726801
申请日：2001-07-11
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： MURARI RAMASWAMY , CHEN JEN-CHI , CHRAI SUGGY S
IPC: G01N33/15 , A61J3/00 , A61K9/70 , A61M15/00 , A61M15/02 , B05C13/00 , B32B3/24 , B05D1/32 , B05B5/00
Abstract: Provided is, among other things, a conductive inlay film comprising; a layer of dielectric film (21) having a pattern of holes (23) suitable to define selected regions to which particles will be deposited by electrostatic deposition; and a conductive element (22) comprising polymer, which element comprises (a) a conductive film laminated (22) against the dielectric film (21) or (b) a conductive film embedded within the holes (23), the portion of the conductive element appearing within the holes comprising conductive inlays, wherein the conductive element (22) is adapted to contact one or more electrode pads and provide electrical potential at the selected regions, and wherein the dielectric film (21) electrically isolates the selected regions.
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