公开(公告)号：WO1996006075A1

公开(公告)日：1996-02-29

申请号：PCT/US1995009957

申请日：1995-08-07

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： EASTMAN CHEMICAL COMPANY ,  LUTZ, Gary, Paul ,  ZIMA, George, Chester ,  BERNARD, Rex

IPC: C07C303/32

CPC classification number: C07C303/32 ,  C07C309/42

Abstract: This invention relates to a five step process for preparing a purified alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate in one reaction vessel without isolation of intermediates. The first step involves reacting an alkali metal salt of 4-hydroxybenzenesulfonic acid with a C2 to C4 carboxylic anhydride in a solvent to form an alkali metal salt of 4-acyloxybenzenesulfonic acid and a C2 to C4 carboxylic acid. The second step involves adding an [(1-oxyalkanoyl)amino]alkanoic acid and a transesterification catalyst to the reaction product of Step (A) and heating at a temperature and pressure sufficient to maintain reflux of the solvent and to remove the C2 to C4 carboxylic acid from the reaction vessel to form a reaction mixture containing an alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate. The third step involves removing solvent from the reaction mixture formed in Step (B). The fourth step involves mixing the alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate product of Step (C) with acetic acid. The fifth step involves separating the product from the acetic acid. The purified alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate product is useful as a bleach activator in detergents.

Abstract translation: 本发明涉及在不分离中间体的情况下，在一个反应​​容器中制备4-磺基苯基 - [（1-氧代烷酰基）氨基]链烷酸酯的纯化碱金属盐的五步法。 第一步是在溶剂中使4-羟基苯磺酸的碱金属盐与C 2〜C 4羧酸酐反应，形成4-酰氧基苯磺酸的碱金属盐和C 2〜C 4羧酸。 第二步包括向步骤（A）的反应产物中加入[（1-氧亚烷基）氨基]链烷酸和酯交换催化剂，并在足以维持溶剂回流并除去C2至C4的温度和压力下加热 羧酸从反应容器中形成含有4-磺基苯基 - [（1-氧代烷酰基）氨基]链烷酸酯的碱金属盐的反应混合物。 第三步涉及从步骤（B）中形成的反应混合物中除去溶剂。 第四步是将步骤（C）的4-磺基苯基 - [（1-氧亚烷基）氨基]链烷酸酯的碱金属盐与乙酸混合。 第五步是将产物与乙酸分离。 纯化的4-磺基苯基 - [（1-氧代烷酰基）氨基]链烷酸酯的碱金属盐可用作洗涤剂中的漂白活化剂。

公开(公告)号：EP0777648B1

公开(公告)日：1999-10-13

申请号：EP95930119.3

申请日：1995-08-07

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： LUTZ, Gary, Paul ,  ZIMA, George, Chester ,  BERNARD, Rex

IPC: C07C303/32 ,  C07C303/44 ,  C07C309/42

CPC classification number: C07C303/32 ,  C07C309/42

Abstract: This invention relates to a five step process for preparing a purified alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate in one reaction vessel without isolation of intermediates. The first step involves reacting an alkali metal salt of 4-hydroxybenzenesulfonic acid with a C2 to C4 carboxylic anhydride in a solvent to form an alkali metal salt of 4-acyloxybenzenesulfonic acid and a C2 to C4 carboxylic acid. The second step involves adding an [(1-oxyalkanoyl)amino]alkanoic acid and a transesterification catalyst to the reaction product of Step (A) and heating at a temperature and pressure sufficient to maintain reflux of the solvent and to remove the C2 to C4 carboxylic acid from the reaction vessel to form a reaction mixture containing an alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate. The third step involves removing solvent from the reaction mixture formed in Step (B). The fourth step involves mixing the alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate product of Step (C) with acetic acid. The fifth step involves separating the product from the acetic acid. The purified alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate product is useful as a bleach activator in detergents.

公开(公告)号：EP0777648A1

公开(公告)日：1997-06-11

申请号：EP95930119.0

申请日：1995-08-07

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： LUTZ, Gary, Paul ,  ZIMA, George, Chester ,  BERNARD, Rex

IPC: B01J23 ,  B01J31 ,  C07B61 ,  C07C303 ,  C07C309

CPC classification number: C07C303/32 ,  C07C309/42

Abstract: This invention relates to a five step process for preparing a purified alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate in one reaction vessel without isolation of intermediates. The first step involves reacting an alkali metal salt of 4-hydroxybenzenesulfonic acid with a C2 to C4 carboxylic anhydride in a solvent to form an alkali metal salt of 4-acyloxybenzenesulfonic acid and a C2 to C4 carboxylic acid. The second step involves adding an [(1-oxyalkanoyl)amino]alkanoic acid and a transesterification catalyst to the reaction product of Step (A) and heating at a temperature and pressure sufficient to maintain reflux of the solvent and to remove the C2 to C4 carboxylic acid from the reaction vessel to form a reaction mixture containing an alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate. The third step involves removing solvent from the reaction mixture formed in Step (B). The fourth step involves mixing the alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate product of Step (C) with acetic acid. The fifth step involves separating the product from the acetic acid. The purified alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate product is useful as a bleach activator in detergents.