公开(公告)号：WO2006039268A2

公开(公告)日：2006-04-13

申请号：PCT/US2005/034587

申请日：2005-09-29

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： HYATT, John, Anthony ,  ZIMA, George, Chester ,  EDGAR, Kevin, Joseph ,  NAVARRO, Lisa, Tonner ,  LEHR, Claus-Michael ,  COLLNOT, Eva-Maria ,  SINGLETON, Andy, Hugh ,  BALDES, Christiane ,  SCHAFER, Ulrich, Friedrich ,  WEMPE, Michael, Fitzpatrick

CPC classification number: A61K9/16 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50

Abstract: Compounds and compositions are disclosed for increasing the bioavailability of lipophilic drugs, and more specifically, to solubilizing lipophilic drugs using bioenhancers that cause no efflux inhibition or a desired degree of efflux inhibition. Methods of making and using such compositions are also disclosed.

Abstract translation: 公开了用于提高亲脂性药物的生物利用度的化合物和组合物，并且更具体地，公开了使用不引起流出抑制或期望的流出抑制程度的生物增强剂溶解亲脂性药物的化合物和组合物。 还公开了制造和使用这种组合物的方法。

公开(公告)号：WO1996014291A1

公开(公告)日：1996-05-17

申请号：PCT/US1995013718

申请日：1995-10-26

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： EASTMAN CHEMICAL COMPANY ,  ZIMA, George, Chester ,  LUTZ, Gary, Paul ,  MCCHESNEY, Gary, Wesley ,  WILLIAMS, Thomas, Hugh

IPC: C07C231/02

CPC classification number: C08G69/16 ,  C07C231/02 ,  C08G69/46

Abstract: This invention relates to a process for recycling waste material selected from amino-carboxylic acid oligomers or polymers and amido-carboxylic acid oligomers or polymers into amido-carboxylic acids. A mixture containing water, an oligomeric or polymeric waste material, and a carboxylic acid is heated. The mixture is cooled to obtain a two phase system containing an aqueous phase and an organic phase which are separated. Carboxylic acids, unreacted starting materials, and the monomeric amido-carboxylic acid product are distilled from the organic phase. The remaining solid residue composed of high boiling oligomeric amino-carboxylic acids is recycled into Step (A).

Abstract translation: 本发明涉及将选自氨基羧酸低聚物或聚合物和酰氨基 - 羧酸低聚物或聚合物的废料回收成酰胺 - 羧酸的方法。 加入含有水，低聚物或聚合物废物和羧酸的混合物。 将混合物冷却以获得含有分离的水相和有机相的两相体系。 从有机相中蒸馏出羧酸，未反应的原料和单体酰氨基 - 羧酸产物。 剩余的由高沸点低聚氨基羧酸组成的固体残余物被再循环到步骤（A）中。

公开(公告)号：WO1995028381A1

公开(公告)日：1995-10-26

申请号：PCT/US1995004344

申请日：1995-04-07

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： EASTMAN CHEMICAL COMPANY ,  ZIMA, George, Chester ,  WILLIAMS, Thomas, Hugh

IPC: C07C231/02

CPC classification number: C07C231/02 ,  Y02P20/582

Abstract: This invention relates to a process for preparing amido-carboxylic acids in water. The process involves four steps. Step (A) involves hydrolyzing a lactam at a temperature of 150 DEG C - 300 DEG C to form a mixture containing an amino acid. Step (B) involves cooling the reaction mixture formed in step (A) to a temperature of 25 DEG C - 100 DEG C. Step (C) involves reacting a carboxylic acid anhydride with the amino acid formed in step (A) to form a reaction mixture containing an organic layer which contains an amido-carboxylic acid and an aqueous layer. Step (D) involves separating the amido-carboxylic acid containing organic layer from the aqueous layer. The presence of water aids in product isolation by phase separation and recycle of the reactants. Amido-carboxylic acids are used to make bleach activators for detergents.

Abstract translation: 本发明涉及在水中制备酰氨基羧酸的方法。 该过程涉及四个步骤。 步骤（A）涉及在150℃至300℃的温度下水解内酰胺以形成含有氨基酸的混合物。 步骤（B）包括将步骤（A）中形成的反应混合物冷却至25℃-100℃。步骤（C）包括使羧酸酐与步骤（A）中形成的氨基酸反应形成 含有含有酰氨基羧酸和水层的有机层的反应混合物。 步骤（D）包括从含水层中分离含酰氨基羧酸的有机层。 水的存在通过相分离和反应物的再循环来辅助产物分离。 氨基羧酸用于制备洗涤剂的漂白活化剂。

公开(公告)号：WO2005026189A1

公开(公告)日：2005-03-24

申请号：PCT/US2004/028465

申请日：2004-09-01

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： ZIMA, George, Chester ,  OLDFIELD, Terry, Ann ,  DOBBS, Suzanne, Winegar ,  COOK, Phillip, Michael ,  KELLY, Charles, Everette ,  CROW, Mary, Caraway ,  HOYME, Craig, Alan

IPC: C07J9/00

CPC classification number: C11B13/00 ,  A23D7/0053 ,  A23D7/0056 ,  A23D7/015 ,  A23D9/013 ,  A23L2/52 ,  A23L27/60 ,  A23L33/105 ,  A23L33/11 ,  A61K8/922 ,  A61K36/889 ,  A61K36/899 ,  A61Q19/00 ,  A61Q19/001 ,  C07D311/72 ,  C07J9/00 ,  C11B11/00 ,  Y02W30/74

Abstract: Disclosed is a process for the recovery of a phytolipid composition from a vegetable oil by-product. The phytolipid composition produced comprises squalene, phytosterols, mixed tocopherols and tocotrieneols, and vegetable wax and is useful as an emollient. The phytochemical composition may be applied directly to the skin to provide emolliency. Alternatively, the phytoiipid composition may be formulated in various aqueous or anhydrous cosmetic compositions such as creams, lotions, gels, ointments, lip balms, sticks, or pencils for treatment of the skin and lips. The phytolipid composition also may be incorporated into foods, beverages, and nutraceuticals to provide health benefits.

Abstract translation: 公开了从植物油副产物中回收植脂油组合物的方法。 所生产的植物油脂组合物包括角鲨烯，植物甾醇，混合生育酚和邻苯三酚，以及植物蜡，并且可用作润肤剂。 植物化学成分可以直接施用于皮肤以提供润肤性。 或者，植物性脂肪组合物可以配制成各种水性或无水化妆品组合物，例如乳膏，洗剂，凝胶，软膏，唇膏，棒或铅笔，用于治疗皮肤和嘴唇。 植物油脂组合物还可以并入食品，饮料和营养品中以提供健康益处。

公开(公告)号：WO1997009299A1

公开(公告)日：1997-03-13

申请号：PCT/US1996014027

申请日：1996-09-04

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： EASTMAN CHEMICAL COMPANY ,  LUTZ, Gary, Paul ,  ZIMA, George, Chester ,  WILLIAMS, Thomas, Hugh

IPC: C07C231/02

CPC classification number: C07C231/08 ,  C07C231/02

Abstract: The present invention relates to a one-step process for preparing amido-carboxylic acid esters having the amide nitrogen positioned between two carbonyl carbons by reacting a carboxylic acid or carboxylic acid ester with a monohydric alcohol and either a lactam, amino-carboxylic acid or a polymeric amino-carboxylic acid. In this process, amidation, esterification, alcoholysis, and hydrolysis reactions occur simultaneously.

Abstract translation: 本发明涉及一种通过使羧酸或羧酸酯与一元醇和内酰胺，氨基羧酸或其盐形成的羧酸或羧酸酯反应制备具有位于两个羰基碳之间的酰胺氮的酰氨基 - 羧酸酯的一步法 聚合氨基羧酸。 在此过程中，酰胺化，酯化，醇解和水解反应同时发生。

公开(公告)号：WO1996039378A1

公开(公告)日：1996-12-12

申请号：PCT/US1996008943

申请日：1996-06-05

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： EASTMAN CHEMICAL COMPANY ,  LUTZ, Gary, Paul ,  ZIMA, George, Chester ,  DICKASON, William, Charles

IPC: C07C303/00

CPC classification number: C07C231/12 ,  C07C303/22 ,  C07C303/32 ,  Y02P20/582 ,  C07C309/42

Abstract: This invention relates to a process for preparing amido ester compounds. The proces involves (I) forming a mixture in a reactor of a phenol derivative and an amido-carboxylic acid at a temperature which ensures at least partial solubility of the phenol derivative and the amido-carboxylic acid, and (II) adding a carboxylic anhydride incrementally to the mixture formed in Step (I) while distilling a by-product carboxylic acid from the reactor. The amido esters are useful as bleach activators.

Abstract translation: 本发明涉及一种制备酰胺酯化合物的方法。 方法涉及（I）在确保苯酚衍生物和酰氨基 - 羧酸至少部分溶解的温度下，在苯酚衍生物和酰氨基羧酸的反应器中形成混合物，和（II）加入羧酸酐 在步骤（I）中形成的混合物中，同时从反应器中蒸馏出副产物羧酸。 酰胺酯可用作漂白活化剂。

公开(公告)号：WO1996006075A1

公开(公告)日：1996-02-29

申请号：PCT/US1995009957

申请日：1995-08-07

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： EASTMAN CHEMICAL COMPANY ,  LUTZ, Gary, Paul ,  ZIMA, George, Chester ,  BERNARD, Rex

IPC: C07C303/32

CPC classification number: C07C303/32 ,  C07C309/42

Abstract: This invention relates to a five step process for preparing a purified alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate in one reaction vessel without isolation of intermediates. The first step involves reacting an alkali metal salt of 4-hydroxybenzenesulfonic acid with a C2 to C4 carboxylic anhydride in a solvent to form an alkali metal salt of 4-acyloxybenzenesulfonic acid and a C2 to C4 carboxylic acid. The second step involves adding an [(1-oxyalkanoyl)amino]alkanoic acid and a transesterification catalyst to the reaction product of Step (A) and heating at a temperature and pressure sufficient to maintain reflux of the solvent and to remove the C2 to C4 carboxylic acid from the reaction vessel to form a reaction mixture containing an alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate. The third step involves removing solvent from the reaction mixture formed in Step (B). The fourth step involves mixing the alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate product of Step (C) with acetic acid. The fifth step involves separating the product from the acetic acid. The purified alkali metal salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate product is useful as a bleach activator in detergents.

Abstract translation: 本发明涉及在不分离中间体的情况下，在一个反应​​容器中制备4-磺基苯基 - [（1-氧代烷酰基）氨基]链烷酸酯的纯化碱金属盐的五步法。 第一步是在溶剂中使4-羟基苯磺酸的碱金属盐与C 2〜C 4羧酸酐反应，形成4-酰氧基苯磺酸的碱金属盐和C 2〜C 4羧酸。 第二步包括向步骤（A）的反应产物中加入[（1-氧亚烷基）氨基]链烷酸和酯交换催化剂，并在足以维持溶剂回流并除去C2至C4的温度和压力下加热 羧酸从反应容器中形成含有4-磺基苯基 - [（1-氧代烷酰基）氨基]链烷酸酯的碱金属盐的反应混合物。 第三步涉及从步骤（B）中形成的反应混合物中除去溶剂。 第四步是将步骤（C）的4-磺基苯基 - [（1-氧亚烷基）氨基]链烷酸酯的碱金属盐与乙酸混合。 第五步是将产物与乙酸分离。 纯化的4-磺基苯基 - [（1-氧代烷酰基）氨基]链烷酸酯的碱金属盐可用作洗涤剂中的漂白活化剂。

公开(公告)号：WO1995028383A1

公开(公告)日：1995-10-26

申请号：PCT/US1995004336

申请日：1995-04-07

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： EASTMAN CHEMICAL COMPANY ,  ZIMA, George, Chester ,  WILLIAMS, Thomas, Hugh ,  SHELTON, Mark, Robert

IPC: C07C231/24

CPC classification number: C07C231/24

Abstract: This invention relates to a four step process for purifying amido-carboxylic acids by liquid/liquid extraction from a reaction mixture containing an amido-carboxylic acid. The first step involves distilling impurities from a reaction mixture containing an amido-carboxylic acid to form a distillate residue. The second step involves mixing the distillate residue with a nonpolar hydrocarbon solvent wherein the mixture is maintained above the freezing point of the distillate residue. The third step involves allowing the hydrocarbon solvent and distillate residue to achieve phase separation of an organic phase containing the amido-carboxylic acid and an organic phase containing the nonpolar hydrocarbon solvent. The fourth step involves separating the organic phase containing the nonpolar hydrocarbon solvent from the organic phase containing the amido-carboxylic acid.

Abstract translation: 本发明涉及通过液体/液体萃取从含有酰氨基 - 羧酸的反应混合物中纯化酰氨基羧酸的四步法。 第一步是从含有酰氨基 - 羧酸的反应混合物中蒸馏出杂质以形成馏出物残余物。 第二步包括将馏出物残余物与非极性烃溶剂混合，其中混合物保持在馏出物残余物的冰点之上。 第三步涉及允许烃溶剂和馏出物残余物实现含有酰氨基 - 羧酸的有机相和含有非极性烃溶剂的有机相的相分离。 第四步骤是从含有酰氨基 - 羧酸的有机相中分离含有非极性烃溶剂的有机相。

公开(公告)号：WO2007115181A2

公开(公告)日：2007-10-11

申请号：PCT/US2007/065655

申请日：2007-03-30

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： WEMPE, Michael, Fitzpatrick ,  EDGAR, Kevin, Joseph ,  ZIMA, George, Chester ,  HYATT, John, Anthony

IPC: A61B5/05

CPC classification number: A61K45/06 ,  A61K31/00 ,  A61K31/352 ,  A61K31/355 ,  A61K31/56 ,  C07J17/00 ,  A61K2300/00

Abstract: At least one compound chosen from compounds of Formula 1: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each Of R 2 , R 3 , R 4 and R 5 is independently chosen from -H, alkyl, substituted aikyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z' is chosen from -O-, -N-, -NO-, - NR 4 -, -S-, -SO- and -SO 2 -, wherein R 4 is defined as above; each of X, X', Y and Z is independently chosen from -CR 4 R 5 -, -NH-, -NR 4 -, -NO-. -O-, -NOR 4 -, -S-, -SO-, -SO 2 -, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 , is chosen from any R 1 , alkyl. substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.

Abstract translation: 至少一种选自式1化合物的化合物：其药学上可接受的盐或酯，其溶剂合物，螯合物，其非共价复合物，其前药，以及上述任何一种的混合物，其中：n为 1至900的数字，其中各个单元可以相同或不同; W选自烷基，取代的烷基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基; R 2，R 3，R 4和R 5中的每一个独立地选自-H，烷基， 取代的芳基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基; Z'选自-O - ， - N-，-NO - ， - NR 4 - ， - S - ， - SO - 和-SO 2 - ，其中 R 4定义如上; X，X'，Y和Z中的每一个独立地选自-CR 4，R 5 - ， - NH - ， - NR 4 - ，-NO-。 -O - ， - NOR 4 - ， - S - ， - SO - ， - SO 2 - ，其中R 4和R 3 > 5 如上所定义; R 1选自生育酚，类固醇和类黄酮; 和R 6，R 6选自任何R 1，C 1-4烷基。 取代的烷基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基。

公开(公告)号：WO2005048744A1

公开(公告)日：2005-06-02

申请号：PCT/US2004/038408

申请日：2004-11-15

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： COOK, Phillip, Michael ,  ZIMA, George, Chester ,  SEXTON, Danessa, Leann

IPC: A23L2/56

CPC classification number: A23L2/56 ,  A23L2/52 ,  A23L2/62 ,  A23L27/80 ,  A23V2002/00 ,  A23V2200/222 ,  A23V2250/5022 ,  A23V2250/1944

Abstract: The present invention provides a solid sucrose acetate isobutyrate (SAIB) formulation, comprising sucrose acetate isobutyrate in an amount from about 1 weight percent to about 80 weight percent based on the total weight percent of the total solid formulation; and a solid substrate that is soluble in water or oil, wherein the substrate is present in an amount from about 99 weight percent to about 30 weight percent based on the weight of the formulation, wherein the formulation is pourable in less than about 20 seconds according to ASTM method D1895-96. The SAIB formulation is useful in beverage applications.

Abstract translation: 本发明提供固体蔗糖乙酸异丁酸酯（SAIB）制剂，其包含占总固体制剂总重量百分比约1重量％至约80重量％的蔗糖乙酸异丁酸酯; 和可溶于水或油的固体基质，其中所述底物的存在量为制剂重量的约99重量％至约30重量％，其中所述制剂在少于约20秒内可倾倒，根据 根据ASTM方法D1895-96。 SAIB配方可用于饮料应用。