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    CHROMATOGRAPHY MEDIA AND METHOD
    2.
    发明专利
    CHROMATOGRAPHY MEDIA AND METHOD 未知

    公开(公告)号：SG186915A1

    公开(公告)日：2013-02-28

    申请号：SG2013000450

    申请日：2011-07-27

    Applicant: EMD MILLIPORE CORP

    Inventor： YAVORSKY DAVID ,  AMARA JOHN ,  UMANA JOAQUIN ,  CATALDO WILLIAM ,  KOZLOV MIKHAIL ,  STONE MATTHEW

    Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).

    HIGH CAPACITY COMPOSITE DEPTH FILTER MEDIA WITH LOW EXTRACTABLES
    3.
    发明专利
    HIGH CAPACITY COMPOSITE DEPTH FILTER MEDIA WITH LOW EXTRACTABLES 未知

    公开(公告)号：SG10202006161UA

    公开(公告)日：2020-07-29

    申请号：SG10202006161U

    申请日：2014-09-02

    Applicant: EMD MILLIPORE CORP

    Inventor： WOO MAYBELLE ,  YAVORSKY DAVID ,  AMARA JOHN ,  SINGH NRIPEN

    Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.

    CHROMATOGRAPHY MEDIA FOR PURIFYING VACCINES AND VIRUSES
    8.
    发明专利
    CHROMATOGRAPHY MEDIA FOR PURIFYING VACCINES AND VIRUSES 未知

    公开(公告)号：CA2897798A1

    公开(公告)日：2014-08-07

    申请号：CA2897798

    申请日：2014-01-03

    Applicant: EMD MILLIPORE CORP

    Inventor： AMARA JOHN ,  CACACE BENJAMIN ,  YAVORSKY DAVID ,  BOYLE JOHN

    IPC: B01D15/04 ,  B01D15/08 ,  B01D15/10

    Abstract: Adsorptive media for chromatography, particularly ionexchange chromatography, derived from a shaped fiber, useful for purifying viruses. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Surface pendant functional groups can be added that provides ion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of viruses, such as influenza.

    CHROMATOGRAPHY MEDIA AND METHOD
    9.
    发明专利
    CHROMATOGRAPHY MEDIA AND METHOD 未知

    公开(公告)号：SG10201803960SA

    公开(公告)日：2018-07-30

    申请号：SG10201803960S

    申请日：2011-07-27

    Applicant: EMD MILLIPORE CORP

    Inventor： YAVORSKY DAVID ,  AMARA JOHN ,  UMANA JOAQUIN ,  CATALDO WILLIAM ,  KOZLOV MIKHAIL ,  STONE MATTHEW

    Abstract: CHROMATOGRAPHY MEDIA AND METHOD Absorptive media for chromatography, particularly ion- exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion- exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs). (Fig. a - 1b)

    HIGH CAPACITY COMPOSITE DEPTH FILTER MEDIA WITH LOW EXTRACTABLES
    10.
    发明专利
    HIGH CAPACITY COMPOSITE DEPTH FILTER MEDIA WITH LOW EXTRACTABLES 未知

    公开(公告)号：SG11201509390TA

    公开(公告)日：2015-12-30

    申请号：SG11201509390T

    申请日：2014-09-02

    Applicant: EMD MILLIPORE CORP

    Inventor： WOO MAYBELLE ,  YAVORSKY DAVID ,  AMARA JOHN ,  SINGH NRIPEN

    IPC: B01D39/16

    Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.

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