中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

18 records (took 0.061 seconds)

    CHROMATOGRAPHY MEDIA AND METHOD
    2.
    发明专利
    CHROMATOGRAPHY MEDIA AND METHOD 未知

    公开(公告)号：SG186915A1

    公开(公告)日：2013-02-28

    申请号：SG2013000450

    申请日：2011-07-27

    Applicant: EMD MILLIPORE CORP

    Inventor： YAVORSKY DAVID ,  AMARA JOHN ,  UMANA JOAQUIN ,  CATALDO WILLIAM ,  KOZLOV MIKHAIL ,  STONE MATTHEW

    Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).

    HIGH CAPACITY COMPOSITE DEPTH FILTER MEDIA WITH LOW EXTRACTABLES
    3.
    发明专利
    HIGH CAPACITY COMPOSITE DEPTH FILTER MEDIA WITH LOW EXTRACTABLES 未知

    公开(公告)号：SG10202006161UA

    公开(公告)日：2020-07-29

    申请号：SG10202006161U

    申请日：2014-09-02

    Applicant: EMD MILLIPORE CORP

    Inventor： WOO MAYBELLE ,  YAVORSKY DAVID ,  AMARA JOHN ,  SINGH NRIPEN

    Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.

    HIGH SURFACE AREA FIBER MEDIA WITH NANO-FIBRILLATED SURFACE FEATURES
    4.
    发明专利
    HIGH SURFACE AREA FIBER MEDIA WITH NANO-FIBRILLATED SURFACE FEATURES 未知

    公开(公告)号：SG11201700030UA

    公开(公告)日：2017-02-27

    申请号：SG11201700030U

    申请日：2015-08-19

    Applicant: EMD MILLIPORE CORP

    Inventor： AMARA JOHN PAUL ,  BOYLE JOHN ,  YAVORSKY DAVID ,  CACACE BENJAMIN

    IPC: B01D15/08

    Abstract: Chromatography media including a high surface area thermoplastic porous nanofiber and an ion-exchange ligand functionality on the surface of the fiber. The porous nanofibers display a convoluted structure that is comprised of discrete bundles of highly entangled nanofibrils that may be fibrillated or ridged. The porous fibers can be prepared through the extraction of a dissolvable mineral or polymeric porogen that is embedded into the fiber during its manufacture in a melt extrusion process.

    HIGH SURFACE AREA FIBER MEDIA WITH NANO-FIBRILLATED SURFACE FEATURES
    9.
    发明专利
    HIGH SURFACE AREA FIBER MEDIA WITH NANO-FIBRILLATED SURFACE FEATURES 未知

    公开(公告)号：CA2954425A1

    公开(公告)日：2016-03-10

    申请号：CA2954425

    申请日：2015-08-19

    Applicant: EMD MILLIPORE CORP

    Inventor： AMARA JOHN PAUL ,  BOYLE JOHN ,  YAVORSKY DAVID ,  CACACE BENJAMIN

    IPC: B01D15/08

    Abstract: Chromatography media including a high surface area thermoplastic porous nanofiber and an ion-exchange ligand functionality on the surface of the fiber. The porous nanofibers display a convoluted structure that is comprised of discrete bundles of highly entangled nanofibrils that may be fibrillated or ridged. The porous fibers can be prepared through the extraction of a dissolvable mineral or polymeric porogen that is embedded into the fiber during its manufacture in a melt extrusion process.

Patent Agency Ranking