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公开(公告)号：WO2015088677A1
公开(公告)日：2015-06-18
申请号：PCT/US2014/064230
申请日：2014-11-06
Applicant: EMD MILLIPORE CORPORATION
Inventor： KOZLOV, Mikhail , CATALDO, William , CARON, Jeffrey
IPC: B01J20/285 , C07K1/14 , C08F20/56
CPC classification number: C07K1/34 , B01D15/10 , B01D37/00 , B01J20/267 , B01J20/288 , B01J20/289 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/3276 , B01J20/3291 , B01J39/26 , B01J2220/80 , C07K1/18 , C07K16/00 , C08F220/18 , C08F220/54 , C08F220/56 , C08F220/58 , C08F259/08 , C08F2220/1825 , C08F2220/1858 , C08J5/2243 , C08J2351/00
Abstract: Novel compositions for removing impurities such as, protein aggregates, from a sample containing a protein of interest, e.g., an antibody. Such compositions can be used prior to the virus filtration step during protein purification, to remove aggregates and protect the virus filter from fouling, therefore improving virus filter capacity. A porous solid support including a co-polymer having at least two monomers, wherein at least one of the monomers comprises acrylamide and at least a second monomer comprises a hydrophobic binding group, where the solid support selectively binds protein aggregates, thereby to separate the monomeric protein of interest from the protein aggregates. The method can be performed under neutral to high pH and high conductivity conditions.
Abstract translation: 用于从含有目的蛋白质的样品例如抗体中除去杂质如蛋白质聚集体的新型组合物。 这样的组合物可以在蛋白质纯化期间的病毒过滤步骤之前使用，以除去聚集体并保护病毒过滤器免于结垢，从而提高病毒过滤能力。 一种多孔固体支持物，包括具有至少两种单体的共聚物，其中所述单体中的至少一种包含丙烯酰胺，并且至少第二单体包含疏水性结合基团，其中所述固体支持物选择性地结合蛋白质聚集体，由此分离单体 来自蛋白质聚集体的目标蛋白质。 该方法可在中性至高pH和高电导条件下进行。
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2.发明申请METHOD OF PURIFYING A BIOLOGICAL MATERIA OF INTEREST IN A SAMPLE USING NANOFIBER ULTRAFILTRATION MEMBRANES OPERATED IN TANGENTIAL FLOW FILTRATION MODE 审中-公开使用NANOFIBER超滤膜在样品中净化生物利用度的方法在流量过滤模式下运行
公开(公告)号：WO2016167871A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/018146
申请日：2016-02-17
Applicant: EMD MILLIPORE CORPORATION
Inventor： CATALDO, William , KOZLOV, Mikhail , XENOPOULOS, Alex , AQUINO, Dennis , NGAN, Clifton
CPC classification number: B01D61/145 , B01D39/1623 , B01D67/0004 , B01D71/54 , B01D71/56 , B01D2239/025 , B01D2315/16 , B01D2323/39 , C07K1/34
Abstract: Embodiments described herein relate to electrospun nanofiber ultrafiltration membrane compositions capable of operating in tangential filtration mode and methods of using the same.
Abstract translation: 本文所述的实施方案涉及能够以切向过滤模式操作的电纺奈米纤维超滤膜组合物及其使用方法。
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公开(公告)号：WO2012015908A3
公开(公告)日：2012-02-02
申请号：PCT/US2011/045519
申请日：2011-07-27
Applicant: EMD MILLIPORE CORPORATION , YAVORSKY, David , AMARA, John , UMANA, Joaquin , CATALDO, William , KOZLOV, Mikhail , STONE, Matthew
Inventor： YAVORSKY, David , AMARA, John , UMANA, Joaquin , CATALDO, William , KOZLOV, Mikhail , STONE, Matthew
IPC: B01D15/36 , B01J20/285 , C07K1/18 , B01J20/28
Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
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公开(公告)号：WO2020051215A1
公开(公告)日：2020-03-12
申请号：PCT/US2019/049540
申请日：2019-09-04
Applicant: EMD MILLIPORE CORPORATION
Inventor： CATALDO, William , AQUINO, Dennis , LANDRY, Nathan , NGAN, Clifton , BARTLETT, Andrew , GOMEZ, Maribel , STRAEFFER, Gregory , LAWSON, Thomas
Abstract: Devices for removing extractables downstream from a filter, including a tangential flow filter, the filter housed within a housing; and an adsorber housed within the frame and downstream of the filter, the adsorber containing media for removing extractables, wherein extractables are removed from a permeate side of the filter without contacting a product of interest, are disclosed.
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5.发明申请REMOVAL OF PROTEIN AGGREGATES FROM BIOPHARMACEUTICAL PREPARATIONS IN A FLOW-THROUGH MODE 审中-公开在流动模式中从生物制剂中去除蛋白质聚集体
公开(公告)号：WO2013138098A1
公开(公告)日：2013-09-19
申请号：PCT/US2013/028845
申请日：2013-03-04
Applicant: EMD MILLIPORE CORPORATION
Inventor： KOZLOV, Mikhail , CATALDO, William , POTTY, Ajish , GALIPEAU, Kevin
CPC classification number: C07K1/22 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J39/20 , B01J39/26 , B01J41/20 , B01J47/026 , C07K1/165 , C07K1/18 , C07K16/00
Abstract: The present invention provides novel compositions and methods for removal of protein aggregates from a sample in a flow-through mode.
Abstract translation: 本发明提供了用于从流通模式中从样品中去除蛋白质聚集体的新型组合物和方法。
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Patent Agency Ranking
公开(公告)号：WO2014004281A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/046995
申请日：2013-06-21
Applicant: EMD MILLIPORE CORPORATION
Inventor： XENOPOULOS, Alex , PHILLIPS, Michael , MOYA, Wilson , JABER, Jad , KOZLOV, Mikhail , POTTY, Ajish , STONE, Matthew, T. , CATALDO, William , GILLESPIE, Christopher
CPC classification number: C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01D15/3847 , C07K16/00 , C07K2317/14 , C12M29/04 , C12M43/00 , C12M47/12 , C12N7/00
Abstract: The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.
Abstract translation: 本发明涉及用于纯化生物分子的改进方法和系统，其中所述方法可以以连续的方式进行。
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7.发明申请USE OF CHARGED FLUOROCARBON COMPOSITIONS IN METHODS FOR PURIFICATION OF BIOMOLECULES 审中-公开在生物分子纯化方法中使用充电氟化物组合物
公开(公告)号：WO2013148389A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/032768
申请日：2013-03-18
Applicant: EMD MILLIPORE CORPORATION
Inventor： KOZLOV, Mikhail , MOYA, Wilson , JABER, Jad , CATALDO, William , POTTY, Ajish , GILLESPIE, Christopher
Abstract: The present invention relates to novel and improved methods for the purification of biomolecules. In particular, the present invention relates to methods of protein purification which employ a porous solid support modified with a charged fluorocarbon composition.
Abstract translation: 本发明涉及用于纯化生物分子的新颖和改进的方法。 特别地，本发明涉及蛋白质纯化方法，该方法采用用带电的碳氟化合物组合物改性的多孔固体支持物。
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公开(公告)号：EP3079808B1
公开(公告)日：2020-05-27
申请号：EP14869655.2
申请日：2014-11-06
Applicant: EMD Millipore Corporation
Inventor： KOZLOV, Mikhail , CATALDO, William , CARON, Jeffrey
IPC: B01J20/285 , B01J20/288 , B01J20/289 , B01J20/32 , B01J39/26 , C07K1/14 , C07K1/18 , C07K1/34 , C07K16/00 , B01D15/10 , B01D37/00 , C08F20/56 , C08F220/58 , C08F220/56 , C08F259/08 , C08F220/18 , C08F220/54 , C08J5/22
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公开(公告)号：EP3130384A1
公开(公告)日：2017-02-15
申请号：EP16181909.9
申请日：2013-06-21
Applicant: EMD Millipore Corporation
Inventor： XENOPOULOS, Alex , PHILLIPS, Michael , MOYA, Wilson , JABER, Jad , KOZLOV, Mikhail , POTTY, Ajish , STONE, Matthew, T. , CATALDO, William , GILLESPIE, Christopher
CPC classification number: C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01D15/3847 , C07K16/00 , C07K2317/14 , C12M29/04 , C12M43/00 , C12M47/12 , C12N7/00
Abstract: The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.
Abstract translation: 本发明涉及用于纯化生物分子的改进方法和系统，其中所述方法可以以连续的方式进行。
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公开(公告)号：EP2598223A2
公开(公告)日：2013-06-05
申请号：EP11813102.8
申请日：2011-07-27
Applicant: EMD Millipore Corporation
Inventor： YAVORSKY, David , AMARA, John , UMANA, Joaquin , CATALDO, William , KOZLOV, Mikhail , STONE, Matthew
IPC: B01D15/36 , B01J20/285 , C07K1/18 , B01J20/28
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/28023 , B01J20/28059 , B01J20/285 , B01J20/287 , B01J20/3244 , B01J41/20 , B01J47/014 , B01J47/127 , C07K1/18 , C07K16/00 , C12N7/00 , C12N7/02 , G01N2030/521 , Y10S502/52724 , Y10T428/2938 , Y10T428/2973
Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
Abstract translation: 来自成形纤维的用于色谱的吸附介质，特别是离子交换层析。 在某些实施方案中，与普通纤维相比，功能化成形纤维呈现原纤化或脊状结构，其大大增加了纤维的表面积。 本文还公开的是向高表面积纤维添加提供阳离子交换或阴离子交换官能团的表面侧基官能团的方法。 这种侧链官能团可用于生物分子的离子交换色谱纯化，如单克隆抗体（mAb）。
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