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公开(公告)号：WO2022086652A1
公开(公告)日：2022-04-28
申请号：PCT/US2021/051083
申请日：2021-09-20
Applicant: EMD MILLIPORE CORPORATION
Inventor： LI, Ying , DUPONT, Alison , WOOD, Amy , FOURNIER, Allyson , GUPTA, Akshat , GAMI, Hiral
IPC: C12M1/00
Abstract: A multi-stage TFF apparatus, comprising a bioreactor capable of holding cell culture media; a first stage TFF device in fluid communication with the bioreactor; a storage tank in fluid communication with the first stage TFF device; a first recirculating loop in fluid communication with the first stage TFF device and the bioreactor; a second stage TFF device, in fluid communication with and downstream from the storage tank; and a second recirculating loop in fluid communication with the second stage TFF device and the storage tank.
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公开(公告)号：WO2013028334A2
公开(公告)日：2013-02-28
申请号：PCT/US2012/049501
申请日：2012-08-03
Applicant: EMD MILLIPORE CORPORATION , JABER, Jad , MOYA, Wilson , POTTY, Ajish , DUPONT, Alison , STONE, Mathew , KOZLOV, Mikhael
Inventor： JABER, Jad , MOYA, Wilson , POTTY, Ajish , DUPONT, Alison , STONE, Mathew , KOZLOV, Mikhael
IPC: A61K39/395 , A61P35/00
CPC classification number: C07K16/00 , B01D15/327 , B01D15/361 , B01D15/3804 , B01D15/3847 , C07K1/30
Abstract: The present invention relates to novel and improved methods for the purification of biomolecules. In particular, the present invention relates to methods of protein purification which employ small molecules, which include al least one non- polar group and at least one cationic group or which include at least one non-polar group and at least one anionic group.
Abstract translation: 本发明涉及用于纯化生物分子的新颖和改进的方法。 特别地，本发明涉及使用包括至少一个非极性基团和至少一个阳离子基团或包括至少一个非极性基团和至少一个阴离子基团的小分子的蛋白质纯化方法。
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公开(公告)号：WO2018222550A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/034709
申请日：2018-05-25
Applicant: EMD MILLIPORE CORPORATION
Inventor： DUPONT, Alison
Abstract: Filter elements (20, 100) for perfusion systems and methods are provided. A filter element sheet includes a microporous membrane (63, 112) having a mean pore size of at least about 0.65µm and a feed spacer (25, 120) comprising woven fibers and having an open area of at least about 35%. The filter element sheet can be arranged within a filter element, for example, in a spiral-wound format or in a cassette format. A perfusion system includes at least one filter element and a pump configured to control flow of a liquid feed through the at least one filter element.
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Patent Agency Ranking
公开(公告)号：WO2021150297A1
公开(公告)日：2021-07-29
申请号：PCT/US2020/060832
申请日：2020-11-17
Applicant: EMD MILLIPORE CORPORATION
Inventor： BERTI PEREZ, Stefano , DUPONT, Alison
IPC: B01D61/18 , C02F3/12 , C12M3/06 , B01D2313/06 , B01D2313/20 , B01D2313/58 , B01D2315/06 , C02F3/1273 , C12M29/04 , C12M47/10
Abstract: The disclosure herein relates to a TFF assembly including a baffle comprising a microporous filter within a bioreactor. The baffle may include a collection receptacle to capture a target product or waste materials within the baffle after passing through the microporous filter.
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公开(公告)号：EP2370561B1
公开(公告)日：2019-08-07
申请号：EP09835506.8
申请日：2009-12-08
Applicant: EMD Millipore Corporation
Inventor： MOYA, Wilson , DUPONT, Alison
IPC: C12M1/00
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公开(公告)号：EP3630937A1
公开(公告)日：2020-04-08
申请号：EP18731317.6
申请日：2018-05-25
Applicant: EMD Millipore Corporation
Inventor： DUPONT, Alison
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公开(公告)号：EP4093534A1
公开(公告)日：2022-11-30
申请号：EP20824014.3
申请日：2020-11-17
Applicant: EMD Millipore Corporation
Inventor： BERTI PEREZ, Stefano , DUPONT, Alison
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公开(公告)号：EP2744518A2
公开(公告)日：2014-06-25
申请号：EP12825346.5
申请日：2012-08-03
Applicant: EMD Millipore Corporation
Inventor： JABER, Jad , MOYA, Wilson , POTTY, Ajish , DUPONT, Alison , STONE, Matthew T. , KOZLOV, Mikhail
IPC: A61K39/395 , A61P35/00
CPC classification number: C07K16/00 , B01D15/327 , B01D15/361 , B01D15/3804 , B01D15/3847 , C07K1/30
Abstract: The present invention relates to novel and improved methods for the purification of biomolecules. In particular, the present invention relates to methods of protein purification which employ small molecules, which include al least one non- polar group and at least one cationic group or which include at least one non-polar group and at least one anionic group.
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