公开(公告)号：WO0118007A3

公开(公告)日：2001-07-26

申请号：PCT/JP0006023

申请日：2000-09-05

Applicant: FUJISAWA PHARMACEUTICAL CO ,  HIGAKI TOMOJI ,  YOSHIYASU TAKASHI ,  HASHIMOTO NORIHIRO ,  HONDA KEIJI ,  HATANAKA HIROSHI ,  YAMASHITA MICHIO

Inventor： HIGAKI TOMOJI ,  YOSHIYASU TAKASHI ,  HASHIMOTO NORIHIRO ,  HONDA KEIJI ,  HATANAKA HIROSHI ,  YAMASHITA MICHIO

IPC: C12P17/16 ,  B01D15/00 ,  B01D15/08 ,  B01D15/42 ,  C07D498/18

CPC classification number: C07D498/18

Abstract: A method for separating a lactone-containing high-molecular weight compound comprising subjecting a mixture of a lactone-containing high-molecular weight compound having, as its side-chain, at least one of a lower alkenyl group and a lower alkoxy group and its analogous compound(s) to either one or both steps in any order of a step (A) for adsorbing the mixture to a nonionic adsorption resin and eluting with an aqueous solvent containing silver ions, and a step (B) for adsorbing the mixture to a basic active alumina and eluting with an organic solvent to separate each of the compounds.

Abstract translation: 一种分离含内酯的高分子量化合物的方法，包括使具有作为其侧链的含内酯的高分子量化合物与低级链烯基和低级烷氧基中的至少一种的内酯的混合物及其 和用于将混合物吸附到非离子吸附树脂上并用含有银离子的含水溶剂洗脱的步骤（A）的任何一个或两个步骤的任何一个或两个步骤的类似化合物和用于将混合物吸附到 碱性活性氧化铝，并用有机溶剂洗脱以分离每种化合物。

公开(公告)号：ES2223514T3

公开(公告)日：2005-03-01

申请号：ES00927830

申请日：2000-05-19

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： NISHIHARA YUTAKA ,  HONDA KEIJI ,  MUKAI KOJI ,  HASHIMOTO NORIHIRO ,  HATANAKA HIROSHI ,  YAMASHITA MICHIO

IPC: B01D15/36 ,  B01D15/00 ,  B01D15/04 ,  B01D15/18 ,  B01J39/04 ,  B01J39/20 ,  B01J39/26 ,  C07D307/00 ,  C07D309/00 ,  C07D498/16 ,  C07D498/18 ,  C08J5/20

Abstract: Un método para separar un compuesto de alto peso molecular que contiene lactona, que tiene un grupo alquilo como cadena lateral, de un compuesto de alto peso molecular que contiene lactona, que tiene un grupo alquenilo como cadena lateral, teniendo los compuestos de alto peso molecular que contienen lactona una estructura química básica común, utilizando una resina de intercambio catiónico fuerte que contiene grupos de ácido sulfónico pretratada con iones de plata, en el que la estructura química básica de los compuestos de alto peso molecular que contienen lactona es 1, 14-dihidroxi-12-[2-(4-hidroxi-3- metoxiciclohexil)-1-metilvinil]-23, 25-dimetoxi-13, 19, 21, 27-

公开(公告)号：CZ2002860A3

公开(公告)日：2002-08-14

申请号：CZ2002860

申请日：2000-09-05

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： HIGAKI TOMOJI ,  YOSHIYASU TAKASHI ,  HASHIMOTO NORIHIRO ,  HONDA KEIJI ,  HATANAKA HIROSHI ,  YAMASHITA MICHIO

IPC: C12P17/16 ,  B01D15/00 ,  B01D15/08 ,  B01D15/42 ,  C07D498/18

Abstract: A method for separating a lactone-containing high-molecular weight compound comprising subjecting a mixture of a lactone-containing high-molecular weight compound having, as its side-chain, at least one of a lower alkenyl group and a lower alkoxy group and its analogous compound(s) to either one or both steps in any order of a step (A) for adsorbing the mixture to a nonionic adsorption resin and eluting with an aqueous solvent containing silver ions, and a step (B) for adsorbing the mixture to a basic active alumina and eluting with an organic solvent to separate each of the compounds.

公开(公告)号：CZ20020860A3

公开(公告)日：2002-08-14

申请号：CZ20020860

申请日：2000-09-05

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： HIGAKI TOMOJI ,  YOSHIYASU TAKASHI ,  HASHIMOTO NORIHIRO ,  HONDA KEIJI ,  HATANAKA HIROSHI ,  YAMASHITA MICHIO

IPC: C12P17/16 ,  B01D15/00 ,  B01D15/08 ,  B01D15/42 ,  C07D498/18

CPC classification number: C07D498/18

公开(公告)号：NO20021024L

公开(公告)日：2002-05-02

申请号：NO20021024

申请日：2002-03-01

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： HIGAKI TOMOJI ,  YOSHIYASU TAKASHI ,  HASHIMOTO NORIHIRO ,  HONDA KEIJI ,  HATANAKA HIROSHI ,  YAMASHITA MICHIO

IPC: C12P17/16 ,  B01D15/00 ,  B01D15/08 ,  B01D15/42 ,  C07D498/18

Abstract: A method for separating a lactone-containing high-molecular weight compound comprising subjecting a mixture of a lactone-containing high-molecular weight compound having, as its side-chain, at least one of a lower alkenyl group and a lower alkoxy group and its analogous compound(s) to either one or both steps in any order of a step (A) for adsorbing the mixture to a nonionic adsorption resin and eluting with an aqueous solvent containing silver ions, and a step (B) for adsorbing the mixture to a basic active alumina and eluting with an organic solvent to separate each of the compounds.

公开(公告)号：BR0011597A

公开(公告)日：2002-03-05

申请号：BR0011597

申请日：2000-05-19

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： NISHIHARA YUTAKA ,  HONDA KEIJI ,  MUKAI KOJI ,  HASHIMOTO NORIHIRO ,  HATANAKA HIROSHI ,  YAMASHITA MICHIO

IPC: B01D15/36 ,  B01D15/00 ,  B01D15/04 ,  B01D15/18 ,  B01J39/04 ,  B01J39/20 ,  B01J39/26 ,  C07D307/00 ,  C07D309/00 ,  C07D498/16 ,  C07D498/18 ,  C08J5/20

Abstract: The present invention relates to a method for separating a lactone-containing high-molecular weight compound having an alkyl group as its side chain from a lactone-containing high-molecular weight compound having an alkenyl group as its side chain by using a sulfonic acid group-containing cation exchange resin pretreated with silver ions.

公开(公告)号：AU775075C

公开(公告)日：2005-02-24

申请号：AU4615400

申请日：2000-05-19

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： NISHIHARA YUTAKA ,  HONDA KEIJI ,  MUKAI KOJI ,  HASHIMOTO NORIHIRO ,  HATANAKA HIROSHI ,  YAMASHITA MICHIO

IPC: B01D15/36 ,  B01D15/00 ,  B01D15/04 ,  B01D15/18 ,  B01J39/04 ,  B01J39/20 ,  B01J39/26 ,  C07D307/00 ,  C07D309/00 ,  C07D498/16 ,  C07D498/18 ,  C08J5/20

Abstract: The present invention relates to a method for separating a lactone-containing high-molecular weight compound having an alkyl group as its side chain from a lactone-containing high-molecular weight compound having an alkenyl group as its side chain by using a sulfonic acid group-containing cation exchange resin pretreated with silver ions.

公开(公告)号：DK1183261T3

公开(公告)日：2005-01-17

申请号：DK00927830

申请日：2000-05-19

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： HONDA KEIJI ,  HASHIMOTO NORIHIRO ,  YAMASHITA MICHIO ,  NISHIHARA YUTAKA ,  MUKAI KOJI ,  HATANAKA HIROSHI

IPC: B01D15/36 ,  B01D15/00 ,  B01D15/04 ,  B01D15/18 ,  B01J39/04 ,  B01J39/20 ,  B01J39/26 ,  C07D307/00 ,  C07D309/00 ,  C07D498/16 ,  C07D498/18 ,  C08J5/20

Abstract: The present invention relates to a method for separating a lactone-containing high-molecular weight compound having an alkyl group as its side chain from a lactone-containing high-molecular weight compound having an alkenyl group as its side chain by using a sulfonic acid group-containing cation exchange resin pretreated with silver ions.

公开(公告)号：DE60013434D1

公开(公告)日：2004-10-07

申请号：DE60013434

申请日：2000-05-19

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： NISHIHARA YUTAKA ,  HONDA KEIJI ,  MUKAI KOJI ,  HASHIMOTO NORIHIRO ,  HATANAKA HIROSHI ,  YAMASHITA MICHIO

IPC: B01D15/36 ,  B01D15/00 ,  B01D15/04 ,  B01D15/18 ,  B01J39/04 ,  B01J39/20 ,  B01J39/26 ,  C07D307/00 ,  C07D309/00 ,  C07D498/16 ,  C07D498/18 ,  C08J5/20

Abstract: The present invention relates to a method for separating a lactone-containing high-molecular weight compound having an alkyl group as its side chain from a lactone-containing high-molecular weight compound having an alkenyl group as its side chain by using a sulfonic acid group-containing cation exchange resin pretreated with silver ions.

公开(公告)号：AT275150T

公开(公告)日：2004-09-15

申请号：AT00927830

申请日：2000-05-19

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： NISHIHARA YUTAKA ,  HONDA KEIJI ,  MUKAI KOJI ,  HASHIMOTO NORIHIRO ,  HATANAKA HIROSHI ,  YAMASHITA MICHIO

IPC: B01D15/36 ,  B01D15/00 ,  B01D15/04 ,  B01D15/18 ,  B01J39/04 ,  B01J39/20 ,  B01J39/26 ,  C07D307/00 ,  C07D309/00 ,  C07D498/16 ,  C07D498/18 ,  C08J5/20

Abstract: The present invention relates to a method for separating a lactone-containing high-molecular weight compound having an alkyl group as its side chain from a lactone-containing high-molecular weight compound having an alkenyl group as its side chain by using a sulfonic acid group-containing cation exchange resin pretreated with silver ions.