公开(公告)号：KR840002294B1

公开(公告)日：1984-12-15

申请号：KR810002646

申请日：1981-07-21

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： IMANAKA HIROSHI ,  MIYOSHI TOSHIO ,  KONOMI TOSHIO ,  KUBOCHI YOSHIAKI ,  HATTORI SEIZIRO ,  KAWAKITA TAKESHI

IPC: C12N9/18 ,  C12P35/06 ,  C12P39/00 ,  C12R1/645 ,  C12R1/745

公开(公告)号：KR840001989B1

公开(公告)日：1984-10-26

申请号：KR840003711

申请日：1984-06-29

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： DAKAYA DAKAO ,  MATSUGI DAKASHI ,  KAWABADA KOJI ,  DAKASUGI HISASHI ,  YAMANAKA HIDEAKI

IPC: C07D501/22

公开(公告)号：KR840001988B1

公开(公告)日：1984-10-26

申请号：KR840003709

申请日：1984-06-29

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： DAKAYA DAKAO ,  MATSUGI DAKASHI ,  KAWABADA KOJI ,  DAKASUGI HISASHI ,  YAMANAKA HIDEAKI

IPC: C07D501/22

公开(公告)号：KR820000903B1

公开(公告)日：1982-05-24

申请号：KR820000596

申请日：1982-02-11

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： HISASHI TAKASUKI ,  TAKAO TAKAYA ,  TIYOSHI CHUJI ,  TOSHIYUKI SIBA

IPC: C07D501/59

Abstract: Title compds. (Ic; R1 = thiazolyl, thiadiazolyl, haloacetyl; R2a = halogen, (esterified) carboxy; R3 = H, haloalkyl; R4 = H, halogen, lower alkyl, -OR7; R7 = H, lower alkyl, acyl; R5 = carboxy or functionally-modified carboxy) were prepd. by etherification of V. Thus, 2.6 g 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido≉-3-cephem-4-carboxylic hydrochloride was treated with 1.04 g sodium bicarbonate at room temp to give 7-≮2-(2-amino-4-thiazolyl)-2-methoxyaminoacetamido≉-3-cephem-4-carboxylate.

公开(公告)号：KR820000741B1

公开(公告)日：1982-05-03

申请号：KR810004879

申请日：1981-12-12

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： NAKAI Y ,  KAMIYA D ,  SAKANE K ,  TANAKA K

IPC: C07D501/36

公开(公告)号：KR790000101B1

公开(公告)日：1979-03-15

申请号：KR740001508

申请日：1974-02-15

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： HASHIMETO MASASHI ,  KAMIYA TAKASHI ,  TERACHI TSUDOMU

Abstract: The penams(I) and cephams(II) (e.g. R =PhCH2, PhOCH2, 2-thienylmethyl, protected phCHNH2; R1 = CH2CCl3, Me; R2 = Cl, Br, OAc, OMe, SCN), useful as antimicrobial agent, were prepd. by cyclizing(III) with a suitable reagent for providing R2. III was prepd. by reaction of thiol compound and 2-methyl-2-lower alkyl-6-substituted penam-3-carboxylicacid-1-oxide. Subsequent reaction of I and II included deacylation, ester hydrolysis, S-oxidn. and substitution at R2..

公开(公告)号：KR850000127B1

公开(公告)日：1985-02-27

申请号：KR740001507

申请日：1974-02-15

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA DAKASI ,  DERASI SUDOMU ,  OKU DERAO ,  HASIMOTO MASASI ,  NAKAGUSI OSAMU

IPC: C07D501/22 ,  C07D501/60

Abstract: Cephemcarboxylic acids I [R1 = H, OAc, 1-methyltetrazol-5ylthio, 2- methyl-1,3,4-thiadiazol-5-ylthio; R2 = Ph, 4-HOC6H4, 3,4-Cl(HO)C6H3 were converted to N-acylation products II [R1 = alkyl; R2 = acylamino; X = S . 2-methyl-7-amino-3-cephem-4-carbonic acid was stirred with diglycolic anhydride in Me2CO at room temperature to give II.

公开(公告)号：KR840001287B1

公开(公告)日：1984-09-07

申请号：KR840002710

申请日：1984-05-18

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： UEDA IKUO ,  NAGANO MASANOBU ,  KATO MASAYUKI

IPC: C07D239/86 ,  C07D487/04 ,  C07D487/14

公开(公告)号：KR820001611B1

公开(公告)日：1982-09-08

申请号：KR820002707

申请日：1982-06-17

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KURODA YOSHIO ,  IKUCHI EIGO ,  IMANAKA HIROSHI ,  OKUHARA MASAKURI ,  AOKI HASTUO ,  KAMIYA TAKASHI

IPC: C07F9/40

Abstract: The title compds.(If; R1α = lower alkenoyl; A = lower alkyene), useful as antibiotics and bactericides, were prepd. by the reaction of Ie≮HN(OH)AP(O)(OH)2≉ and R1α-OH. phosphonylation of R1N(0R2)AX1≮R1 = olwer alkoxycarbonyl, a enesulfonyl; R2 = ar(lower)alkyl; X1 = acid residue≉wich POR3(0R3)2 [R3 = H, ester residue; R3 α=ester residue, followed by hy2 drolysis to give If.

公开(公告)号：KR820000904B1

公开(公告)日：1982-05-24

申请号：KR820000597

申请日：1982-02-11

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： TOSHIYUKI SIBA ,  TAKAO TAKAYA ,  HISASHI TAKASUKI ,  TIYOSHI CHUJI

IPC: C07D501/59

Abstract: Title compds. (Id; R6 = (protected) amino; R2 = H, halogen, carboxy; R3 = H, lower alkyl; R4a = H, halogen, lower alkyl, -O-R7; R7 = lower alkyl; R5 = carboxy) were prepd. by the reaction of VI(R1b = haloacetyl) with VII. Thus, 2.6 ml 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido≉-3-cephem-4-carboxylic hydrochloride and stirred at room temp to give 7-≮2-(2-amino-4-thiazolyl)-2-methoxyaminoacetamido≉-3-cephem-4-carboxylate.