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    PRODUCTION OF L-ARGININE
    1.
    发明专利
    PRODUCTION OF L-ARGININE 失效

    公开(公告)号：JP2000080072A

    公开(公告)日：2000-03-21

    申请号：JP18860599

    申请日：1999-07-02

    Applicant: FUJISAWA PHARMACEUTICAL CO

    Inventor： MUKAI KOJI ,  MUKUDA TAKASHI ,  KAWAKAMI RYOICHI

    IPC: C07C277/08 ,  C07C279/14

    Abstract: PROBLEM TO BE SOLVED: To obtain L-arginine having a small crystal particle size distribution width in good particle size distribution repeatability and suitable for powder filling treatments by adding a specific amount of L-arginine crystals as seed crystals to a supersaturated solution of the L-arginine, when the L-arginine is crystallized. SOLUTION: This method for producing arginine crystals comprises crystallizing L-arginine. Therein, L-arginine crystals are added as seed crystals to the supersaturated solution of the L-arginine. The L-arginine crystals use for the seed crystals are preferably particulate L-arginine which has an average particle diameter of 100-300 μm and to which many fine L-arginine crystals (preferably fine L-arginine crystals having a particle diameter of 0.5-2 μm in an amount of 1×109 to 1×1011 crystals/g of the seed crystals) are preferably adhered as secondary nuclei used as the crystallization of the L-arginine. The L-arginine crystals used as the seed crystals may be fine L-arginine crystals obtained by grinding L-arginine crystals by the use of a grinder, etc., and having a particle diameter of 0.5-2 μm.

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