公开(公告)号：JPS61257962A

公开(公告)日：1986-11-15

申请号：JP9847985

申请日：1985-05-09

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： YAZAWA HISATOYO ,  KAGARA KOUJI ,  KAWAI NOBUTAKA ,  KAKIMOTO SATOSHI

IPC: C07D263/42 ,  B01J23/00 ,  B01J23/04 ,  B01J31/00 ,  B01J31/02 ,  C07B61/00 ,  C07C67/00 ,  C07C313/00 ,  C07C319/20 ,  C07C323/62

Abstract: PURPOSE:To obtain the titled compound useful as a synthetic intermediate for dibenzothiepin derivatives simply at a low cost, by passing a benzaldehyde compound and a thiophenol compound as raw materials through novel intermediates. CONSTITUTION:A novel compound expressed by formula I (R is H or halogen) is reacted with a compound expressed by formula II (R is lower alkyl or aryl) or a salt thereof to give a novel compound expressed by formula III, which is then subjected to hydrolysis reaction to afford a novel intermediate expressed by formula IV or a salt thereof. The resultant compound expressed by formula IV or salt thereof is treated with hydrogen peroxide in the presence of a base to give the aimed compound, expressed by formula V and useful as a synthetic intermediate for dibenzothiepin derivatives useful as a remedy for schizophrenia. The novel compound expressed by formula I can be obtained from an inexpensive benzaldehyde compound and thiophenol compound and the production process is industrially advantageous.