公开(公告)号：JPH064640B2

公开(公告)日：1994-01-19

申请号：JP13245684

申请日：1984-06-26

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： YAZAWA HISATOYO ,  ICHIHARA MASAHARU ,  KAGARA KOJI ,  MUKUDA TAKASHI

IPC: C07D501/04

公开(公告)号：JPH026357B2

公开(公告)日：1990-02-08

申请号：JP9902382

申请日：1982-06-08

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： YAZAWA HISATOYO ,  HIBI FUMIO ,  GOSHIMA SHUNSUKE

IPC: C07D501/04 ,  C07D501/20

公开(公告)号：JPH0147462B2

公开(公告)日：1989-10-13

申请号：JP3063280

申请日：1980-03-11

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMYA TAKASHI ,  YAZAWA HISATOYO ,  HIBI FUMIO ,  GOSHIMA SHUNSUKE ,  ICHIHARA MASAHARU

IPC: C07C251/32 ,  C07C251/38 ,  C07C275/26 ,  C07D501/34

公开(公告)号：JPS616075B2

公开(公告)日：1986-02-24

申请号：JP4553975

申请日：1975-04-14

Applicant: Fujisawa Pharmaceutical Co

Inventor： TANAKA KUNIHIKO ,  YAZAWA HISATOYO ,  NAKAMURA HITOSHI

IPC: C07D501/04 ,  C07D501/60

公开(公告)号：JPH0584296B2

公开(公告)日：1993-12-01

申请号：JP19067585

申请日：1985-08-28

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： YAZAWA HISATOYO ,  HASHIMOTO NORIO ,  KAGARA KOJI

IPC: C07C69/708 ,  C07C67/27

公开(公告)号：JPS6248648A

公开(公告)日：1987-03-03

申请号：JP19067585

申请日：1985-08-28

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： YAZAWA HISATOYO ,  HASHIMOTO NORIO ,  KAKARA KOUJI

IPC: C07C69/708 ,  C07C67/27

Abstract: PURPOSE:To obtain the titled compound useful as a synthetic intermediate for 1,4-dihydropyridine compound which is useful as a medicine, under mild condition in high yield in single step reaction, by using glyoxylic acid as a starting compound and reacting the acid with an ortho ester. CONSTITUTION:Glyoxylic acid of formula or its salt is used as a starting compound and is made to react with an ortho ester of formula II (R is lower alkyl or lower alkoxy-lower alkyl) in a non-aqueous solvent such as methanol under moderate heating or heating at about the boiling point of the solvent to obtain the objective compound of formula III. The amount of the compound of formula II is preferably 3-5mol, especially about 4mol per 1mol of the compound of formula I. the above reaction is carried out preferably in the presence of a catalyst such as hydrogen chloride, sulfuric acid, acetic acid, methanesulfonic acid, etc. The amount of the acid is between catalytic amount and 2mol, preferably about 0.1mol per 1mol of glyoxylic acid used as a raw material.

公开(公告)号：JPS61218581A

公开(公告)日：1986-09-29

申请号：JP5896285

申请日：1985-03-22

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： YAZAWA HISATOYO ,  TAKEUCHI TOSHIO ,  KONO KEIKO ,  GOSHIMA SHUNSUKE

IPC: C07B43/06 ,  C07B31/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07D285/12 ,  C07D285/125

Abstract: NEW MATERIAL:The thine compound of formula I (R is H or lower alkyl; R is acyl). EXAMPLE:3-Formyl-5-methyl-1,3,4-thiadiazole-2(3H)-thione. USE:An acylation agent. PREPARATION:The compound of formula I can be produced by reacting the thiadiazole compound of formula II or its salt with an acylation agent comprising the organic acid of formula R -OH or its derivative such as acetic anhydride in the presence of a base such as pyridine or a condensation agent at room temperature or under cooling.

公开(公告)号：JPS614838B2

公开(公告)日：1986-02-13

申请号：JP4448075

申请日：1975-04-11

Applicant: Fujisawa Pharmaceutical Co

Inventor： TANAKA KUNIHIKO ,  YAZAWA HISATOYO ,  NAKAMURA HITOSHI

IPC: C07D519/06 ,  A61K31/545 ,  A61P31/04 ,  C07D501/04 ,  C07D501/26

公开(公告)号：JPS51133296A

公开(公告)日：1976-11-18

申请号：JP5807375

申请日：1975-05-14

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： TANAKA KUNIHIKO ,  YAZAWA HISATOYO ,  NAKAMURA HITOSHI

IPC: C07D501/04 ,  A61K31/545 ,  C07D501/60

Abstract: PURPOSE:Processes for preparing the titled compounds of formula II by the hydrolysis of compounds of formula I or by the reaction of the compounds of formula I with N,N,-dialkylamides in the presence of a silver compound, followed by the hydrolysis.

公开(公告)号：JPS51127092A

公开(公告)日：1976-11-05

申请号：JP4948775

申请日：1975-04-22

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： TANAKA KUNIHIKO ,  YAZAWA HISATOYO ,  NAKAMURA HITOSHI

IPC: C07D501/04 ,  A61K31/545 ,  C07D501/26

Abstract: PURPOSE:7-Acylamino-3-heterocyclicoxymethyl-3-cephem-4-carboxylic acid derivatives of formula I are new: (where R1 is acyl; R2 is heterocyclic group; X is halogen), in an example, 7-(2-phenylacetamido)-3-(1,2,5-thiadiazol-3-yl)oxymethyl-3-cephem-4-ca rboxylicacid.