公开(公告)号：KR820000741B1

公开(公告)日：1982-05-03

申请号：KR810004879

申请日：1981-12-12

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： NAKAI Y ,  KAMIYA D ,  SAKANE K ,  TANAKA K

IPC: C07D501/36

公开(公告)号：US3823152A

公开(公告)日：1974-07-09

申请号：US17234771

申请日：1971-07-29

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： NAKAI Y ,  WATANABE T ,  MORIMOTO A ,  TAKASUGI H

IPC: C07D211/72 ,  C07D235/16 ,  C07D29/36

CPC classification number: C07D211/72 ,  C07D235/16 ,  Y10S514/927

Abstract: THIS INVENTION RELATES TO COMPOUNDS OF THE FORMULA:

HN THESE COMPOUNDS INHIBIT GASTRIC SECRETION AND ARE USEFUL IN TREATMENT FOR A DIGESTIVE ULCER.

-H, -CH3, PHENYL, PHENYL-CH2-

AND R3" IS SELECTED FROM THE GROUP CONSISTING OF

2-PYRIDYL, PHENYL, 4-(H3C-)-PYRIDYL, -CH2-(2-PYRIDYL),

WHEREIN N IS 3 OR 4, R2" IS SELECTED FROM THE GROUP CONSISTING OF

公开(公告)号：SE8103640L

公开(公告)日：1981-06-10

申请号：SE8103640

申请日：1981-06-10

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA T ,  HASHIMOTO M ,  NAKAGUTI O ,  OKU T ,  NAKAI Y ,  TAKENO H

IPC: C07C323/25 ,  C07D205/08 ,  C07D205/085 ,  C07D205/095 ,  C07D251/04

Abstract: This invention relates to new 2-azetidinone compounds, which have antimicrobial activities, and to processes for the preparation thereof, and more particularly, this invention provides new 2-azetidinone compounds, especially ones having various substituted carboxyalkyl radicals at the first position and having various groups at the fourth position of the azetidinone nucleus, which have antimicrobial activities against various pathogenic microorganisms and are useful as antibiotics in treatment for microbial infections in mammal including human being and animals.

公开(公告)号：DK502078A

公开(公告)日：1979-05-15

申请号：DK502078

申请日：1978-11-10

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA T ,  TERAJI T ,  NAKAI Y ,  SAKANE K ,  GOTO J

IPC: C07D213/55 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D213/73 ,  C07D213/75 ,  C07D213/79 ,  C07D213/80 ,  C07D239/42 ,  C07D239/46 ,  C07D501/20 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36 ,  C07D501/57 ,  C07D501/59 ,  C07D519/06 ,  C07F7/10 ,  C07D

Abstract: A novel compound, useful as an intermediate in the production of compounds of high antimicrobial activity, of the formula: wherein Ra1 is hydrogen, amino or a protected amino group, Rb1 and Rc1 are each hydrogen, halogen, lower alkoxy or arylthio, R14 is carboxy or a protected carboxy group, X is lower alkylene or a group of the formula: in which R6 is hydrogen or an organic residue which may have suitable substituent(s), and Z is N or CH, or a salt thereof.

公开(公告)号：NZ174222A

公开(公告)日：1978-04-03

申请号：NZ17422274

申请日：1974-07-05

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： SAITO Y ,  KAMIYA T ,  TAKAI K ,  TANAKA K ,  YAZAWA H ,  NAKAI Y ,  KISHIMOTO T ,  TERAJI T

IPC: A61K31/545 ,  C07C335/22 ,  C07D501/20

公开(公告)号：ZA7701060B

公开(公告)日：1978-01-25

申请号：ZA7701060

申请日：1977-02-22

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： SAKANE K ,  KAMIYA T ,  TANAKA K ,  NAKAI Y

IPC: C07D277/20 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D277/34 ,  C07D277/40 ,  C07D501/20 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07C

CPC classification number: Y02P20/55

公开(公告)号：BE850085A

公开(公告)日：1977-07-04

申请号：BE173836

申请日：1977-01-04

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA T ,  HASHIMOTO M ,  NAGAGUTI O ,  OKU T ,  NAKAI Y ,  TAKEMO H

IPC: A61K31/395 ,  A61K31/397 ,  A61P31/00 ,  C07C323/25 ,  C07D205/08 ,  C07D205/085 ,  C07D205/095 ,  C07D251/04 ,  C07D333/00 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07F9/568

公开(公告)号：SE437832B

公开(公告)日：1985-03-18

申请号：SE7702547

申请日：1977-03-07

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA T ,  TANAKA K ,  NAKAI Y ,  SAKANE K

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/32 ,  C07D277/34 ,  C07D277/38 ,  C07D277/40 ,  C07D277/44 ,  C07D277/46 ,  C07D277/48 ,  C07D277/52 ,  C07D501/20 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36

Abstract: Antibiotic cephalosporin compounds, method of making and pharmaceutical composition thereof represented by the general formula wherein R1 is amino, lower alkylamino, a protected amino, a protected lower alkylamino, hydroxy or lower alkoxy, R2 is hydrogen, acyloxy, pyridium or a heterocyclicthio group which may have suitable substituent(s), R3 is carboxy or its derivative, A is carbonyl, hydroxy(lower)alkylene or a protected hydroxy(lower)alkylene and R4 is hydrogen or halogen, or R2 and R3 are linked together to represent a group of the formula -COO-, this divisional application being directed to intermediate compounds of the formula:

公开(公告)号：SE8302027L

公开(公告)日：1983-04-12

申请号：SE8302027

申请日：1983-04-12

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA T ,  TANAKA K ,  NAKAI Y ,  SAKANE K

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/32 ,  C07D277/34 ,  C07D277/38 ,  C07D277/40 ,  C07D277/44 ,  C07D277/46 ,  C07D277/48 ,  C07D277/52 ,  C07D501/20 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36 ,  C07D277/42

Abstract: Antibiotic cephalosporin compounds, method of making and pharmaceutical composition thereof represented by the general formula wherein R1 is amino, lower alkylamino, a protected amino, a protected lower alkylamino, hydroxy or lower alkoxy, R2 is hydrogen, acyloxy, pyridium or a heterocyclicthio group which may have suitable substituent(s), R3 is carboxy or its derivative, A is carbonyl, hydroxy(lower)alkylene or a protected hydroxy(lower)alkylene and R4 is hydrogen or halogen, or R2 and R3 are linked together to represent a group of the formula -COO-, this divisional application being directed to intermediate compounds of the formula:

公开(公告)号：ZA7605984B

公开(公告)日：1978-05-30

申请号：ZA7605984

申请日：1976-10-06

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA T ,  HASHIMOTO M ,  TAKENO H ,  NAKAGUTI O ,  OKU T ,  NAKAI Y

IPC: C07D251/04 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/41 ,  A61K31/42 ,  A61K31/425 ,  A61K31/655 ,  A61K31/675 ,  A61P31/04 ,  C07C67/00 ,  C07C227/00 ,  C07C241/00 ,  C07C251/24 ,  C07C313/00 ,  C07C325/00 ,  C07C327/38 ,  C07C327/58 ,  C07D20060101 ,  C07D205/00 ,  C07D205/08 ,  C07D205/085 ,  C07D205/095 ,  C07D209/00 ,  C07D209/48 ,  C07D251/00 ,  C07D251/14 ,  C07D307/00 ,  C07D307/54 ,  C07D333/00 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D407/06 ,  C07D407/12 ,  C07D407/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07F9/568 ,  C07D